Abstract: Mixing systems for producing a mixture to deliver to a treatment site. An illustrative system may comprise a needle hub and a multi-reservoir system including a plunger assembly and a barrel portion. The barrel portion may include a first lumen, a second lumen, and a plurality of channels formed in a wall of the first lumen. A first movable gasket may divide the first lumen into a first reservoir configured to contain a first constituent and a second reservoir configured to contain a second constituent. A second gasket may bound a third reservoir configured to contain a third constituent. Actuating the plunger assembly relative to the barrel portion may first cause the diluent to be injected into the second reservoir to form a precursor and then cause the precursor and the second constituent to be delivered into the needle hub.

Abstract: A multi-chamber device having a barrel with a first chamber and a second chamber, and a plunger assembly with a first plunger rod advanceable with respect to the first chamber and a second plunger rod advanceable with respect to the second chamber. The ends of the first and second plunger rods are independently advanceable to advance different amounts of material from the first and second chamber as the plunger assembly is advanced with respect to the barrel. The multi-chamber device may be part of a multi-chamber system including an injection system. The multi-chamber device and the injection system may include engaging elements facilitating ready coupling and decoupling of the multi-chamber device and the injection system.

Abstract: Devices, systems, and methods for combining and/or delivering an injectable material to a patient. A first device having a first nozzle is moved rotationally and/or generally axially with respect to a second device having a first nozzle port to seat the first nozzle with respect to the first nozzle port. The second device has a nozzle pocket positioned, sized, shaped, configured, and/or dimensioned with respect to the first nozzle port to guide axial and/or rotational relative movements of the first injectable material transfer device and the second injectable material transfer device to guide the first nozzle into alignment with the first nozzle port, such as to be seated with respect to the first nozzle port.

Abstract: Devices, systems, and methods for combining and/or delivering an injectable material to a patient. The injectable material may be formed of two or more reactive components delivered in separate chambers. Various features are provided to reduce human error in combining the reactive components in the appropriate sequence to form the injectable material, generally at (e.g., immediately prior to) the time of delivery to a patient. The system includes a sleeve lock which facilitates coupling of a device having a first chamber containing a first component with a vial having a second chamber containing a second component to combine the first and second components. The combined first and second components are contained within the first chamber for delivery to a patient via an injection system, which may be fluidly coupled with the first chamber with the assistance of the sleeve lock.

Abstract: Mixing systems for producing a mixture to deliver to a treatment site. An illustrative system may comprise a needle hub and a multi-reservoir system. The multi-reservoir system may comprise a first plunger assembly, a second plunger assembly, and a barrel portion. The first plunger assembly, the second plunger assembly, and the barrel portion may be assembled in a telescoping arrangement. Advancing the first plunger assembly may cause a first constituent to be delivered from a first reservoir of the second plunger assembly into the third reservoir to mix with a third constituent to form a precursor and a second constituent to be delivered from a second reservoir of the second plunger assembly into the fourth reservoir and advancing the first and second plunger assembly collectively causes the precursor and the second constituent to be delivered into the needle hub.

Abstract: Mixing systems for producing a mixture to deliver to a treatment site. An illustrative system may comprise a needle hub, a multi-reservoir system, and a syringe. The multi-reservoir system may comprise a plunger assembly including a first plunger and a second plunger, a barrel portion including a housing defining a first reservoir in fluid communication with a first port and configured to contain a first constituent and a second reservoir configured to contain a second constituent and in fluid communication with a second port, and a cap including a port and a lumen extending therethrough. A third constituent may be injected from the syringe into the first reservoir via the port of the cap to form a precursor. Actuating the plunger assembly relative to the barrel portion may cause the precursor and the second constituent to be delivered into the needle hub.

Abstract: Mixing systems for producing a mixture to deliver to a treatment site. An illustrative system may comprise a needle hub, a multi-reservoir system, and a syringe. The multi-reservoir system may comprise a plunger assembly including a first tubular plunger and a second tubular plunger, a barrel portion including a housing defining a first reservoir in fluid communication with a first port and configured to contain a first constituent and a second annular reservoir configured to contain a second constituent and in fluid communication with a second port, and a third plunger. A third constituent may be injected from the syringe into the first reservoir to form a precursor. Actuating the plunger assembly relative to the barrel portion may cause the precursor and the second constituent to be delivered into the needle hub.