Abstract: Method for diagnosing bone disorders comprising assaying bone morphogenetic protein (BMP) or anti-bone morphogenetic protein (anti-BMP) antibody in body fluids. The diagnosis may be carried out by comparing the BMP, anti-BMP antibody or the ratio of the two to normal assay standards. A diagnostic kit for accomplishing these methods is described.

Abstract: The production and isolation of bone morphogenetic peptide agents displaying the osteoinductive and immunoreactive activity of bone morphogenetic protein (BMP) and deriving from natural, synthetic or recombinant DNA sources, and said agents.

Abstract: BMP compositions including the human factor and bovine factor thereof, the process of isolating BMP compositions and factors, and the use of such factors and compositions to induce bone formation in animals.

Abstract: BMP compositions including the human factor and bovine factor thereof, the process of isolating BMP compositions and factors, and the use of such factors and compositions to induce bone formation in animals.

Abstract: BMP compositions including the human factor and bovine factor thereof, the process of isolating BMP compositions and factors, and the use of such factors and compositions to induce bone formation in animals are disclosed.

Abstract: Disclosed is a biodegradable porous ceramic delivery system useful for delivery of bone morphogenic protein (BMP) to viable tissue and to induce formation of new bone therein. The delivery composite is substantially pure BMP in combination with a biodegradable porous ceramic (sintered), e.g. beta-tricalcium phosphate, and may be prepared by admixing the BMP with the porous ceramic material. The composition is implanted in viable tissue where the BMP is slowly released and induces formation of new bone.

Abstract: Disclosed is a biodegradable polylactic acid polymer delivery system for delivery of bone morphogenic protein (BMP) to induce formation of new bone in viable tissue. The delivery composition is substantially pure BMP in combination with a biodegradable polylactic acid polymer and it is prepared by admixing the BMP with the biodegradable polymer. The composition is implanted in viable tissue where the BMP is slowly released and induces formation of new bone.

Abstract: A delivery system for delivering bone morphogenetic protein to induce formation of new bone in viable tissue. The delivery composition comprises substantially pure bone morphogenetic protein and polymethylmethacrylate and it is prepared by admixing the bone morphogenetic protein and polymethylmethacrylate. The composition is implanted in viable tissue where the bone morphogenetic protein is slowly released and induces formation of new bone.

Abstract: Bone morphogenetic protein (BMP) made by the process comprising the steps of demineralizing bone tissue; treating the demineralized bone tissue under aqueous conditions with a water soluble neutral salt and a solubilizing agent for the BMP, the agent being selected from the group consisting of urea and guanidine, and thereby transforming the bone collagen to gelatin and extracting BMP into the solution of solubilizing agent; and separating the solubilizing agent and neutral salt from the solution, thereby precipitating BMP in the aqueous medium, and the BMP has a molecular weight in the range of 1,000-100,000.

Abstract: The process of separating bone morphogenetic protein (BMP) from bone tissue comprising the steps of demineralizing bone tissue; treating the demineralized bone tissue under aqueous conditions with a water soluble neutral salt and a solubilizing agent for the BMP, the agent being selected from the group consisting of urea and guanidine, and thereby transforming the bone collagen to gelatin and extracting BMP into the solution of solubilizing agent; and separating the solubilizing agent and neutral salt from the solution, thereby precipitating BMP in the aqueous medium.