Patents by Inventor Marston Linehan
Marston Linehan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9517224Abstract: Disclosed is a method of activating protein kinase C theta (PKC?) in an HIV or HTLV infected animal comprising administering to the animal an effective amount of a compound of formula (I): Formula (I), or an epimer thereof; wherein Ar and R1-R6 are described herein. Examples of diseases or conditions associated with PKC? include HIV1 infection, AIDS, HTLV infection, and adult T cell leukemia/lymphoma.Type: GrantFiled: November 13, 2013Date of Patent: December 13, 2016Assignee: The United States of America as represented by the Secretary, Department of Health and Human ServicesInventors: Leonard M. Neckers, Carole Sourbier, Jane B. Neckers, Min-Jung Lee, John A. Beutler, W. Marston Linehan, Bradley T. Scroggins, Sunmin Lee
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Publication number: 20150283111Abstract: Disclosed is a method of activating protein kinase C theta (PKC?) in an HIV or HTLV infected animal comprising administering to the animal an effective amount of a compound of formula (I): Formula (I), or an epimer thereof; wherein Ar and R1-R6 are described herein. Examples of diseases or conditions associated with PKC? include HIV1 infection, AIDS, HTLV infection, and adult T cell leukemia/lymphoma.Type: ApplicationFiled: November 13, 2013Publication date: October 8, 2015Applicant: The United States of America,as represented by the Secretary,Department of Health and Human ServicesInventors: Leonard M. Neckers, Carole Sourbier, Jane B. Neckers, Min-Jung Lee, John A. Beutler, W. Marston Linehan, Bradley T. Scroggins, Sunmin Lee
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Patent number: 9101601Abstract: Disclosed are methods of treating an animal for insulin resistance and associated diseases or conditions, activating the transcriptional activity of heat shock factor 1 (HSF1), or inducing the expression of heat shock protein 70 (HSP70) in an animal in need thereof, wherein the methods involve administering an effective amount of one or more compounds of formula (I) or an epimer thereof, wherein Ar, and R1-R6 are described herein. Examples of diseases or conditions associated with insulin resistance include diabetes, obesity, inflammation, metabolic syndrome, polycystic ovary disease, arteriosclerosis, non-alcoholic fatty liver disease, reproductive abnormality in a female, and growth abnormality.Type: GrantFiled: January 3, 2013Date of Patent: August 11, 2015Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Leonard M. Neckers, Carole A.C. Sourbier, W. Marston Linehan, Jane B. Neckers, Min-Jung Lee, Bradley T. Scroggins, John A. Beutler
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Publication number: 20150045307Abstract: The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and methods of using the nucleic acids and proteins encoded thereby. In particular, the present disclosure relates to methods of diagnosing BHD disease and related conditions, such as spontaneous pneumothorax and kidney cancer, and methods of treating BHD skin lesions.Type: ApplicationFiled: October 21, 2014Publication date: February 12, 2015Applicant: The Government of the United States of America as represented by the Secretary of the Department ofInventors: Laura S. Schmidt, Michelle B. Warren, Jorge R. Toro, Berton Zbar, Michael L. Nickerson, W. Marston Linehan, Maria L. Turner
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Publication number: 20140350093Abstract: Disclosed are methods of treating an animal for insulin resistance and associated diseases or conditions, activating the transcriptional activity of heat shock factor 1 (HSF1), or inducing the expression of heat shock protein 70 (HSP70) in an animal in need thereof, wherein the methods involve administering an effective amount of one or more compounds of formula (I) or an epimer thereof, wherein Ar, and R1-R6 are described herein. Examples of diseases or conditions associated with insulin resistance include diabetes, obesity, inflammation, metabolic syndrome, polycystic ovary disease, arteriosclerosis, non-alcoholic fatty liver disease, reproductive abnormality in a female, and growth abnormality.Type: ApplicationFiled: January 3, 2013Publication date: November 27, 2014Inventors: Leonard M. Neckers, Carole A.C. Sourbier, W. Marston Linehan, Jane B. Neckers, Min-Jung Lee, Bradley T. Scroggins, John A. Beutler
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Patent number: 8853277Abstract: The invention provides therapeutic methods that include administering a stable nitroxide to a subject that has, is suspected to have, or is at risk for having a condition associated with reduced VHL or elevated HIF-2?.Type: GrantFiled: November 30, 2010Date of Patent: October 7, 2014Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: W. Marston Linehan, Tracey A. Rouault, James Mitchell, Murali K. Cherukuri
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Publication number: 20120295937Abstract: The invention provides therapeutic methods that include administering a stable nitroxide to a subject that has, is suspected to have, or is at risk for having a condition associated with reduced VHL or elevated HIF-2?.Type: ApplicationFiled: November 30, 2010Publication date: November 22, 2012Applicant: USDHHS Office of Technology, NIHInventors: W. Marston Linehan, Tracey A. Rouault, James Mitchell, Murali K. Cherukuri
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Publication number: 20110288031Abstract: The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and methods of using the nucleic acids and proteins encoded thereby. In particular, the present disclosure relates to methods of diagnosing BHD disease and related conditions, such as spontaneous pneumothorax and kidney cancer, and methods of treating BHD skin lesions.Type: ApplicationFiled: July 11, 2011Publication date: November 24, 2011Inventors: Laura S. Schmidt, Michelle Warren, Jorge R. Toro, Berton Zbar, Michael L. Nickerson, W. Marston Linehan, Maria L. Turner
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Patent number: 8003764Abstract: The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and antibodies that specifically bind to the BHD protein (folliculin). In addition, the present disclosure relates to methods of diagnosing BHD disease and related conditions, such as spontaneous pneumothorax and kidney cancer, by detection of altered expression of folliculin using folliculin-specific antibodies.Type: GrantFiled: December 12, 2008Date of Patent: August 23, 2011Assignee: United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Laura S. Schmidt, Michelle Warren, Jorge R. Toro, Berton Zbar, Michael L. Nickerson, W. Marston Linehan, Maria L. Turner
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Publication number: 20090192086Abstract: The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and methods of using the nucleic acids and proteins encoded thereby. In particular, the present disclosure relates to methods of diagnosing BHD disease and related conditions, such as spontaneous pneumothorax and kidney cancer, and methods of treating BHD skin lesions.Type: ApplicationFiled: December 12, 2008Publication date: July 30, 2009Inventors: Laura S. Schmidt, Michelle Warren, Jorge R. Toro, Berton Zbar, Michael L. Nickerson, W. Marston Linehan, Maria L. Turner
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Patent number: 7485709Abstract: The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and methods of using the nucleic acids and proteins encoded thereby. In particular, the present disclosure relates to methods of diagnosing BHD disease and related conditions, such as spontaneous pneumothorax and kidney cancer, and methods of treating BHD skin lesions.Type: GrantFiled: May 30, 2003Date of Patent: February 3, 2009Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Laura S. Schmidt, Michelle Warren, Jorge P. Toro, Berton Zbar, Michael L. Nickerson, W. Marston Linehan, Maria L. Turner
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Patent number: 6982168Abstract: The present invention relates to immortalized, malignant, human, adult prostate epithelial cell lines or cell lines derived therefrom useful in the diagnosis and treatment of prostate cancer. More particularly, the present invention relates to cloned, immortalized, malignant, human, adult prostate epithelial cell lines and uses of these cell lines for the diagnosis and treatment of cancer. Furthermore, the present invention provides for the characterization of said cell lines through the analysis of specific chromosomal deletions.Type: GrantFiled: January 30, 1997Date of Patent: January 3, 2006Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Suzanne L. Topalian, W. Marston Linehan, Robert K. Bright, Cathy D. Vocke
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Patent number: 6867038Abstract: A method of microdissection which involves forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes a selectively activatable adhesive layer which provides, for example, chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated, the transfer surface and tissue sample are separated.Type: GrantFiled: February 9, 2001Date of Patent: March 15, 2005Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Lance A. Liotta, Michael Emmert-Buck, David B. Krizman, Rodrigo Chuaqui, W. Marston Linehan, Jeffry M. Trent, Robert F. Bonner, Seth R. Goldstein, Paul D. Smith, John I. Peterson
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Publication number: 20020037269Abstract: A method of microdissection which involves forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes a selectively activatable adhesive layer which provides, for example, chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated, the transfer surface and tissue sample are separated.Type: ApplicationFiled: February 9, 2001Publication date: March 28, 2002Inventors: Lance A. Liotta, Michael Emmert-Buck, David B. Krizman, Rodrigo Chuaqui, W. Marston Linehan, Jeffry M. Trent, Robert F. Bonner, Seth R. Goldstein, Paul D. Smith, John I. Peterson
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Patent number: 6312890Abstract: The Von Hippel-Lindau (VHL) disease gene and its corresponding cDNA are disclosed. Methods for detecting carriers of the VHL disease gene using probes derived from the VHL disease gene sequence are described. Pharmaceutical compositions and methods of treating diseases related to the VHL gene are also disclosed.Type: GrantFiled: March 28, 1996Date of Patent: November 6, 2001Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: W. Marston Linehan, Michael I. Lerman, Farida Latif, Berton Zbar
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Patent number: 6251516Abstract: A method of microdissection which involves forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes a selectively activatable adhesive layer which provides, for example, chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated, the transfer surface and tissue sample are separated.Type: GrantFiled: February 4, 1998Date of Patent: June 26, 2001Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Robert F. Bonner, Lance A. Liotta, Michael Emmert-Buck, David B. Krizman, Rodrigo Chuaqui, W. Marston Linehan, Jeffry M. Trent, Seth R. Goldstein, Paul D. Smith, John I. Peterson
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Patent number: 6251467Abstract: A method of microdissection which involves forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes a selectively activatable adhesive layer which provides, for example, chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated, the transfer surface and tissue sample are separated.Type: GrantFiled: July 29, 1999Date of Patent: June 26, 2001Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Lance A. Liotta, Michael Emmert-Buck, David B. Krizman, Rodrigo Chuaqui, W. Marston Linehan, Jeffry M. Trent, Robert F. Bonner, Seth R. Goldstein, Paul D. Smith, John I. Peterson
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Patent number: 5759790Abstract: The invention is the Von Hippel-Lindau (VHL) disease gene and its corresponding cDNA protein product, and antibodies therefore. Methods for detecting carriers of the VHL disease gene using probes derived from the cDNAs are described. Antibodies and methods of detecting the Von-Hippel-Lindau protein are also described.Type: GrantFiled: June 5, 1995Date of Patent: June 2, 1998Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Michael I. Lerman, Farida Latif, Berton Zbar, Marston Linehan
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Patent number: 5654138Abstract: The invention is the Yon Hippel-Lindau (VHL) disease gene and its corresponding cDNA. Methods for detecting carriers of the VHL disease gene using probes derived from the cDNAs are described.Type: GrantFiled: May 14, 1993Date of Patent: August 5, 1997Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Michael I. Lerman, Farida Latif, Berton Zbar, Marston Linehan
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Patent number: 5173509Abstract: A method is disclosed for the treatment of hypercalcemia in a patient, by administering to the patient an effective amount of suramin, or an active analogue thereof, for lowering calcium plasma levels in the patient. Human data shows a single course of treatment lowers plasma calcium levels to normal for three months.Type: GrantFiled: March 29, 1990Date of Patent: December 22, 1992Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: McClellan M. Walther, Renato V. LaRocca, Charles E. Myers, Cy A. Stein, W. Marston Linehan