Abstract: A diagnostic disc includes a disc-shaped body having raised walls that encircle the interior of the disc-shaped body and at least one protrusion extending outwardly from the disc-shaped body. The raised walls of the disc-shaped body define a cavity of the disc-shaped body. A non-contact sensor is attached to each of the at least one protrusion. A printed circuit board (PCB) is positioned within the cavity formed on the disc-shaped body. A vacuum and high temperature tolerant power source is disposed on the PCB along with a wireless charger and circuitry that is coupled to each non-contact sensor and includes at least a wireless communication circuit and a memory. A cover is positioned over the cavity of the disc-shaped body and shields at least a portion of the PCB, circuitry, power source, and wireless charger within the cavity from an external environment.

Abstract: The invention relates to the field of diagnostic immunology. Provided are means and methods for multiparameter cytometry-based leukocyte subsetting, which is advantageously used for the monitoring of the immune status of a subject, and/or for monitoring the effects of an immune modulatory treatment. Provided among others is a reagent composition comprising antibodies conjugated to a detectable label, the conjugated antibodies being directed against the following combination of markers: CD141, HLA-DR, CD16, CD33, CD300e, CD303 and CD14, wherein the antibodies directed against CD300e and CD303 may be conjugated to the same label.

Abstract: A multi-purpose smartcard is disclosed. a computer-implemented method of controlling a smartcard. The smartcard can include a near-field communication (NFC) system. The NFC system can be configured to communicate with remote computing systems. The smartcard can include one or more computing chips embedded in the smartcard. The smartcard receives, from a provisioning computing system accessible to a user, a transaction type indicator and transaction data, the transaction type indicator indicating a particular transaction type from a plurality of potential transaction types. The smartcard stores, in the one or more computer-readable media of the one or more computing chips, the transaction data. The smartcard communicates, using the NFC communication system and in accordance with the transaction type, the transaction data to an authentication computing system.

Abstract: An analysis system includes a reflective substrate; a hollow elongate structure with two ends; two polymer supports coupled to the ends and joined to the substrate; a piezoelectric device coupled to the substrate and designed to produce vibrations in the elongate structure; a laser for emitting a beam; a beam splitter; a photodetector; an amplification module; and a processor. The laser beam passes through the cavity and is absorbed by the photodetector, which generates a signal that is transmitted to the amplification module. The amplification module separates the signal into a modulated component and an unmodulated component. The signal is transmitted to the processor to obtain the resonance frequency and reflectance and to provide the piezoelectric device with an excitation signal at the resonance frequency.

Abstract: The invention relates to compounds inhibiting plexin-A2 and/or plexin-A4, with said compounds specifically targeting plexin-A2 and/or plexin-A4 on or in CD8-positive (CD8+) T-cells. Medical uses of such compounds are also part of the invention.

Abstract: The invention relates to a host cell, preferably a Myceliophthora thermophila cell, which presents a lower expression and/or secretion of non-contributory cellulolytic enzymes, preferably where the non-contributory cellulolytic enzyme is endoglucanase 6 comprising SEQ ID NO: 2, thereby promoting the presence of contributory cellulolytic enzymes in the enzymatic cocktail synthesised by said host cell. The invention also relates to the use of said host cells and the enzymatic cocktails synthesised by said host cells for the production of fermentable sugars of biomass and a method for producing bioproducts, preferably bioethanol, comprising the use of said host cell or the composition according to the invention.

Abstract: A detector of thermal neutrons, fast neutrons and gamma photons that is based on a Cherenkov radiation detector in water and that allows large active volumes of detection at a relatively low cost and higher intensity signals, wherein said detector comprises a container comprising at least a lid; a photon reflective and diffusive coating inside the container; an aqueous solution contained in the container, which comprises sodium chloride (NaCl); and a light sensing device optically coupled to the aqueous solution.

Abstract: A diagnostic disc includes a disc-shaped body having raised walls that encircle the interior of the disc-shaped body and at least one protrusion extending outwardly from the disc-shaped body. The raised walls of the disc-shaped body define a cavity of the disc-shaped body. A non-contact sensor is attached to each of the at least one protrusion. A a printed circuit board (PCB) is positioned within the cavity formed on the disc-shaped body. A vacuum and high temperature tolerant power source is disposed on the PCB along with a wireless charger and circuitry that is coupled to each non-contact sensor and includes at least a wireless communication circuit and a memory. A cover is positioned over the cavity of the disc-shaped body and shields at least a portion of the PCB, circuitry, power source, and wireless charger within the cavity from an external environment.

Abstract: A diagnostic disc includes a disc-shaped body having raised walls that encircle the interior of the disc-shaped body and at least one protrusion extending outwardly from the disc-shaped body. The raised walls of the disc-shaped body define a cavity of the disc-shaped body. A non-contact sensor is attached to each of the at least one protrusion. A a printed circuit board (PCB) is positioned within the cavity formed on the disc-shaped body. A vacuum and high temperature tolerant power source is disposed on the PCB along with a wireless charger and circuitry that is coupled to each non-contact sensor and includes at least a wireless communication circuit and a memory. A cover is positioned over the cavity of the disc-shaped body and shields at least a portion of the PCB, circuitry, power source, and wireless charger within the cavity from an external environment.

Abstract: A substrate support assembly is described herein that includes a facility plate, a ground plate coupled to the facility plate, a fluid conduit disposed within the substrate support assembly disposed through the facility plate and the ground plate, and a connector coupled to the ground plate that houses a portion of the fluid conduit. The connector includes a biasing assembly and a fastener disposed in a pocket formed in the ground plate.

Abstract: Methods of semiconductor processing may include performing a process on a semiconductor substrate. The semiconductor substrate may be seated on a substrate support positioned within a processing region of a semiconductor processing chamber. The methods may include flowing a first backside gas through the substrate support at a first flow rate. The methods may include removing the semiconductor substrate from the processing region of the semiconductor processing chamber. The methods may include performing a plasma cleaning operation within the processing region of the semiconductor processing chamber. The methods may include flowing a second backside gas through the substrate support at a second flow rate. At least a portion of the second backside gas may flow into the processing region through accesses in the substrate support.

Abstract: This invention relates to the field of primary immunodeficiencies (PID), more specifically to means and method for the diagnosis of PID of the lymphoid system. Provided are unique reagent compositions for the flow cytometric immunophenotyping of leukocytes comprising fluorochrome-conjugated antibodies directed against various specific combinations of markers. Also provided are kits comprising the reagent compositions, and methods using the same.

Abstract: In a general aspect, a computer-implemented method can include receiving, by a device including a plurality of functional elements, an indication of a service to be implemented by the device. The method can also include determining one or more functional elements of the device that are needed to implement the service. The one or more functional elements needed to implement the service can be a subset of the plurality of functional elements of the device. The method can further include initializing the device by activating the one or more functional elements needed to implement the service.

Abstract: This invention relates to the field of primary immunodeficiencies (PID), more specifically to means and method for the diagnosis of PID of the lymphoid system. Provided are unique reagent compositions for the flow cytometric immunophenotyping of leukocytes comprising fluorochrome-conjugated antibodies directed against various specific combinations of markers. Also provided are kits comprising the reagent compositions, and methods using the same.

Abstract: The invention refers to polypeptides with polysaccharide monooxygenase activity, to a host cell that expresses them, preferably a Myceliophthora thermophila cell that recombinantly expresses at least one of these polypeptides, to an enzymatic composition comprising at least one of these polypeptides, preferably together with other cellulolytic enzymes, the use of this host cell, of at least one of the polypeptides with polysaccharide monooxygenase activity or of the enzymatic composition for the degradation of cellulosic biomass and to a process for the production of bioproducts, preferably bioethanol, including the use of this host cell, of at least one of the polypeptides of the invention or of the enzymatic composition of the invention.

Abstract: The invention refers to methods and compositions for stabilizing and increasing the activity of enzymatic mixtures comprising GH61 (PMO or polysaccharide monooxigenase) polypeptides used for the degradation of cellulosic material during the saccharification step of biofuel production processes. This improvement is achieved by the addition of a nickel cation to said enzymatic mixtures before and/or during the saccharification step. Thus, the invention provides compositions comprising PMOs, cellulolytic enzymes and a nickel cation, as well as methods for preparing said compositions and methods for producing fermentable sugars and bioproducts, preferably bioethanol, from cellulosic biomass in which said compositions are used.

Abstract: The invention generally relates to novel and improved nucleic acid sequences encoding a polypeptide or protein having the enzymatic activity of a phytase and methods for effectively expressing such enzymes in a host cell. In a first aspect, the present invention relates an isolated nucleic acid molecule i) comprising the nucleotide sequence according to SEQ ID NO: 1 encoding a protein with phytase activity or ii) having a sequence identity of at least 83% to a nucleotide sequence according to SEQ ID NO: 1 encoding a protein with phytase activity. The present invention also relates to an expression construct or a vector comprising the above mentioned isolated nucleic acid molecule.

Abstract: Aspects of the subject technology relate to systems and methods for sharing encrypted information among multiple devices. A peer-to-peer connection between a first computing device associated with a user account and a second computing device associated with the user account is established. Information associated with at least a portion of a file system of the second computing device may be received by the first computing device, where the portion of the file system comprises encrypted data. The portion of the file system of the second computing device may be mounted on the first computing device based on the received information.

Abstract: The invention relates to a host cell, preferably a Myceliophthora thermophila cell, which presents a lower expression and/or secretion of non-contributory cellulolytic enzymes, preferably where the non-contributory cellulolytic enzyme is endoglucanase 6 comprising SEQ ID NO: 2, thereby promoting the presence of contributory cellulolytic enzymes in the enzymatic cocktail synthesised by said host cell. The invention also relates to the use of said host cells and the enzymatic cocktails synthesised by said host cells for the production of fermentable sugars of biomass and a method for producing bioproducts, preferably bioethanol, comprising the use of said host cell or the composition according to the invention.

Abstract: A computing device includes a housing, a processor, memory, a human interface device (i.e., a keyboard or a trackpad), and a biometric sensor integrated into the housing. The biometric sensor is configured for capturing biometric data (i.e., heartbeat data or a vein scan) from one or more of hands of a user of the device while the user's fingers are interacting with the human interface device. The memory stores executable instructions that, when executed by the at least one processor, cause the computing device to: compare the captured biometric data to one or more records of biometric data associated with the user; determine, based on the comparison, whether the captured biometric data satisfies a matching condition with the one or more records of biometric data; and authenticate the user, when the captured biometric data satisfies the matching condition.