Abstract: The present invention relates to an occluder device (1) comprising a supporting structure (2) adapted to anchor the septum (7) of a heart (103) when crossing a septum defect (107); said supporting structure (2) comprising a supporting structure periphery (5) delimiting a structure central opening (6); said occluder device (1) further comprising a membrane (8); said membrane (8) comprises a membrane body (11) having a membrane periphery (12); said membrane (8) has a closed position in which the membrane (8) is in a configuration which provides maximum occlusion to the structure central opening (6); the membrane periphery (12) is fastened to said supporting structure periphery (5) to cover the structure central opening (6); said membrane (8) comprising at least one slit (21); when actively engaged by an external device (108) the membrane (8) deforms the slit (21) which elastically extends, creating a passage lumen (27); in which said membrane (8) comprises at least one permanent passage lumen or shunt lumen (13

Abstract: The present invention relates to compounds for medical use in the treatment or in the prevention or in the diagnosis of arterial or venous thromboembolism.

Abstract: A crossable interseptal occluder device has a support structure having a central support structure portion delimiting a lumen, anchoring portions, and is configured to contract and expand between a compressed configuration and an expanded configuration in which the anchoring portions extend radially outwards from the central support structure portion to compress a partition by arranging the support structure astride the partition through a defect or hole. A diaphragm configured to close the majority of the lumen when the diaphragm is in a relaxed configuration, allows a medical device inserted into a first compartment delimited by the partition to pass through the diaphragm and the lumen entering a second compartment. The diaphragm has a plurality of occluding bridges, each having an elongated body with body ends and longitudinal edges. In the relaxed configuration of the diaphragm, each occluding bridge is arranged close to a further occluding bridge.