Patents by Inventor Marta Castaldi

Marta Castaldi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of sofosbuvir
    Patent number: 10112967
    Abstract: A process for the synthesis of Sofosbuvir is provided comprising the steps of selectively mono-deacetylating a compound of formula (V) enzymatically using a resin supported lipase B derived from Candida Antarctica to obtain a compound formula (IV), then converting the compound of formula (IV) to a compound of formula (II) by reacting the compound of formula (IV) with a compound of formula (III), and then converting the compound of formula (II) to Sofosbuvir of formula (I) by deacetylation reaction.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: October 30, 2018
    Assignee: HC-PHARMA AG
    Inventors: Mauro Gaboardi, Giuseppe Pallanza, Marco Baratella, Graziano Castaldi, Marta Castaldi
  • SOFOSBUVIR IN CRYSTALLINE FORM AND PROCESS FOR ITS PREPARATION
    Publication number: 20180079771
    Abstract: Sofosbuvir in crystalline Form ?, process for its production and use in pharmaceutical compositions.
    Type: Application
    Filed: November 28, 2017
    Publication date: March 22, 2018
    Inventors: Mauro GABOARDI, Marta CASTALDI, Graziano CASTALDI, Sara HELMY
  • Sofosbuvir in crystalline form and process for its preparation
    Patent number: 9845335
    Abstract: Sofosbuvir in crystalline Form ?, process for its production and use in pharmaceutical compositions.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: December 19, 2017
    Assignee: HC-PHARMA AG
    Inventors: Mauro Gaboardi, Marta Castaldi, Graziano Castaldi, Sara Helmy
  • Process for the synthesis of Dapsone and its intermediates
    Patent number: 9845289
    Abstract: A process for the synthesis of Dapsone and intermediates thereof are described.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: December 19, 2017
    Assignee: SEEGPHARM SA
    Inventors: Marco Baratella, Graziano Castaldi, Marta Castaldi, Mauro Gaboardi, Giuseppe Pallanza
  • PROCESS FOR THE PREPARATION OF SOFOSBUVIR
    Publication number: 20170247404
    Abstract: The present invention relates to a process for the synthesis of Sofosbuvir.
    Type: Application
    Filed: November 22, 2016
    Publication date: August 31, 2017
    Inventors: Mauro GABOARDI, Giuseppe PALLANZA, Marco BARATELLA, Graziano CASTALDI, Marta CASTALDI
  • PROCESS FOR THE SYNTHESIS OF DAPSONE AND ITS INTERMEDIATES
    Publication number: 20170217883
    Abstract: A process for the synthesis of Dapsone and intermediates thereof are described.
    Type: Application
    Filed: July 29, 2015
    Publication date: August 3, 2017
    Inventors: Marco BARATELLA, Graziano CASTALDI, Marta CASTALDI, Mauro GABOARDI, Giuseppe PALLANZA
  • SOFOSBUVIR IN CRYSTALLINE FORM AND PROCESS FOR ITS PREPARATION
    Publication number: 20170051004
    Abstract: Sofosbuvir in crystalline Form ?, process for its production and use in pharmaceutical compositions.
    Type: Application
    Filed: July 29, 2015
    Publication date: February 23, 2017
    Inventors: Mauro GABOARDI, Marta CASTALDI, Graziano CASTALDI, Sara HELMY
  • PROCESS FOR THE PREPARATION OF COLESEVELAM
    Publication number: 20160311941
    Abstract: The present invention relates to a new process for the synthesis of Colesevelam, which is used in therapy in cases of hypercholesterolemia due to low density lipoproteins. Said process comprises the reaction, in a basic environment, of polyallylamine with: i) at least one alkylating agent of formula X—(CH2)9—CH3 and at least one alkylating agent of formula Y—(CH2)6—N+ (CH3)3Z?, wherein X and Y are each independently a leaving group, and Z is a halogen; and ii) at least one crosslinking agent. The present invention also relates to the Colesevelam obtainable by the above process.
    Type: Application
    Filed: December 16, 2014
    Publication date: October 27, 2016
    Inventors: Mauro Gaboardi, Alessandro Baruto, Marta Castaldi
  • INTERMEDIATES USEFUL FOR THE PREPARATION OF SAXAGLIPTIN
    Publication number: 20160107992
    Abstract: Intermediates useful for the synthesis of saxagliptin and their preparationare described.
    Type: Application
    Filed: June 18, 2014
    Publication date: April 21, 2016
    Inventors: Graziano CASTALDI, Giuseppe PALLANZA, Mauro GABOARDI, Marta CASTALDI
  • PROCESS AND INTERMEDIATES FOR THE PREPARATION OF DASATINIB
    Publication number: 20150259337
    Abstract: The present invention relates to a process for the synthesis of dasatinib and to intermediates useful for its preparation.
    Type: Application
    Filed: February 26, 2015
    Publication date: September 17, 2015
    Inventors: Alessandro BARUTO, Mauro GABOARDI, Marta CASTALDI, Graziano CASTALDI
  • Process and intermediates for the preparation of dasatinib
    Patent number: 9115124
    Abstract: The present invention relates to a process for the synthesis of dasatinib and to intermediates useful for its preparation.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: August 25, 2015
    Assignee: CERBIOS-PHARMA SA
    Inventors: Alessandro Baruto, Mauro Gaboardi, Marta Castaldi, Graziano Castaldi