Abstract: Aspects of the disclosure relate to transferrin receptor 1 (TfR1) binding proteins and methods of use. In some cases, methods and compositions for preventing cancer comprising the use of TfR1-binding proteins are described. Embodiments include methods for preventing cancer, for example cancer caused by an infectious agent (e.g., Epstein-Barr virus), using a TfR1-binding protein. In some embodiments, the disclosed methods and compositions involve one or more antibodies that are capable of binding TfR1. Certain aspects relate to chimeric antibodies and antibody-like molecules.