Patents by Inventor Martha Allen Zeiger

Martha Allen Zeiger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alternative splice variant patterns of human telomerase reverse transcriptase (hTERT) in thyroid tumors to distinguish benign from malignant
    Patent number: 10774389
    Abstract: This invention relates, e.g., to a method for determining if a thyroid tumor in a subject is malignant, comprising determining in a sample from the subject the amount of TERT (telomerase reverse transcriptase) mRNA which lacks the ? sequence and the amount of TERT mRNA in the sample which comprises the ? sequence, wherein a preponderance (e.g., at least about 55%) of TERT mRNA in the sample which comprises the ? sequence indicates that the tumor is malignant, and wherein a preponderance of TERT mRNA which lacks the ? sequence indicates that the tumor is not malignant.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: September 15, 2020
    Assignee: The Johns Hopkins University
    Inventors: Martha Allen Zeiger, Jeanne Kowalski, Christopher Umbricht, Yongchun Wang
  • ALTERNATIVE SPLICE VARIANT PATTERNS OF HUMAN TELOMERASE REVERSE TRANSCRIPTASE (hTERT) IN THYROID TUMORS TO DISTINGUISH BENIGN FROM MALIGNANT
    Publication number: 20180216192
    Abstract: This invention relates, e.g., to a method for determining if a thyroid tumor in a subject is malignant, comprising determining in a sample from the subject the amount of TERT (telomerase reverse transcriptase) mRNA which lacks the ? sequence and the amount of TERT mRNA in the sample which comprises the ? sequence, wherein a preponderance (e.g., at least about 55%) of TERT mRNA in the sample which comprises the ? sequence indicates that the tumor is malignant, and wherein a preponderance of TERT mRNA which lacks the ? sequence indicates that the tumor is not malignant.
    Type: Application
    Filed: September 29, 2017
    Publication date: August 2, 2018
    Inventors: Martha Allen Zeiger, Jeanne Kowalski, Christopher Umbricht, Yongchun Wang
  • ALTERNATIVE SPLICE VARIANT PATTERNS OF HUMAN TELOMERASE REVERSE TRANSCRIPTASE (hTERT) IN THYROID TUMORS TO DISTINGUISH BENIGN FROM MALIGNANT
    Publication number: 20160326592
    Abstract: This invention relates, e.g., to a method for determining if a thyroid tumor in a subject is malignant, comprising determining in a sample from the subject the amount of TERT (telomerase reverse transcriptase) mRNA which lacks the ? sequence and the amount of TERT mRNA in the sample which comprises the ? sequence, wherein a preponderance (e.g., at least about 55%) of TERT mRNA in the sample which comprises the ? sequence indicates that the tumor is malignant, and wherein a preponderance of TERT mRNA which lacks the ? sequence indicates that the tumor is not malignant.
    Type: Application
    Filed: December 10, 2015
    Publication date: November 10, 2016
    Inventors: Martha Allen Zeiger, Jeanne Kowalski, Christopher Umbricht, Yongchun Wang
  • Diagnostic tool for diagnosing benign versus malignant thyroid lesions
    Patent number: 9234244
    Abstract: The present invention relates to the use of genes differentially expressed in benign thyroid lesions and malignant thyroid lesions for the diagnosis and staging of thyroid cancer.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: January 12, 2016
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Johns Hopkins University
    Inventors: Martha Allen Zeiger, Nijaguna B. Prasad, Steven K. Libutti, Christopher B. Umbricht
  • Alternative splice variant patterns of human telomerase reverse transcriptase (hTERT) in thyroid tumors to distinguish benign from malignant
    Patent number: 9222136
    Abstract: This invention relates, e.g., to a method for determining if a thyroid tumor in a subject is malignant, comprising determining in a sample from the subject the amount of TERT (telomerase reverse transcriptase) mRNA which lacks the ? sequence and the amount of TERT mRNA in the sample which comprises the ? sequence, wherein a preponderance (e.g., at least about 55%) of TERT mRNA in the sample which comprises the ? sequence indicates that the tumor is malignant, and wherein a preponderance of TERT mRNA which lacks the ? sequence indicates that the tumor is not malignant.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: December 29, 2015
    Assignee: The Johns Hopkins University
    Inventors: Martha Allen Zeiger, Jeanne Kowalski, Christopher Umbricht, Yongchun Wang
  • DIAGNOSTIC TOOL FOR DIAGNOSING BENIGN VERSUS MALIGNANT THYROID LESIONS
    Publication number: 20100285979
    Abstract: The present invention relates to the use of genes differentially expressed in benign thyroid lesions and malignant thyroid lesions for the diagnosis and staging of thyroid cancer.
    Type: Application
    Filed: August 27, 2008
    Publication date: November 11, 2010
    Inventors: Martha Allen Zeiger, Nijaguna B. Prasad, Steven K. Libutti, Christopher B. Umbricht
  • ALTERNATIVE SPLICE VARIANT PATTERNS OF HUMAN TELOMERASE REVERSE TRANSCRIPTASE (hTERT) IN THYROID TUMORS TO DISTINGUISH BENIGN FROM MALIGNANT
    Publication number: 20100260670
    Abstract: This invention relates, e.g., to a method for determining if a thyroid tumor in a subject is malignant, comprising determining in a sample from the subject the amount of TERT (telomerase reverse transcriptase) mRNA which lacks the ? sequence and the amount of TERT mRNA in the sample which comprises the ? sequence, wherein a preponderance (e.g., at least about 55%) of TERT mRNA in the sample which comprises the ? sequence indicates that the tumor is malignant, and wherein a preponderance of TERT mRNA which lacks the ? sequence indicates that the tumor is not malignant.
    Type: Application
    Filed: December 5, 2008
    Publication date: October 14, 2010
    Applicant: The Johns Hopkins University
    Inventors: Martha Allen Zeiger, Jeanne Kowalski, Christopher Umbricht, Yongchun Wang