Patents by Inventor Martha Hayden-Ledbetter

Martha Hayden-Ledbetter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS
    Publication number: 20230057085
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Application
    Filed: March 16, 2022
    Publication date: February 23, 2023
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun
  • Therapeutic nuclease compositions and methods
    Patent number: 11306297
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: April 19, 2022
    Assignee: University of Washington
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun
  • Therapeutic Nuclease Compositions and Methods
    Publication number: 20210395711
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Application
    Filed: May 19, 2021
    Publication date: December 23, 2021
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun
  • Therapeutic nuclease compositions and methods
    Patent number: 11034944
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: June 15, 2021
    Assignee: University of Washington
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun
  • Therapeutic Nuclease Compositions and Methods
    Publication number: 20190119660
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Application
    Filed: December 21, 2018
    Publication date: April 25, 2019
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun
  • Therapeutic nuclease compositions and methods
    Patent number: 10202588
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: February 12, 2019
    Assignee: The University of Washington
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun
  • Therapeutic Nuclease Compositions and Methods
    Publication number: 20180187174
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Application
    Filed: August 17, 2017
    Publication date: July 5, 2018
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun
  • Therapeutic nuclease compositions and methods
    Patent number: 10000745
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Grant
    Filed: January 19, 2015
    Date of Patent: June 19, 2018
    Assignee: University of Washington
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun
  • Therapeutic nuclease compositions and methods
    Patent number: 9790479
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: October 17, 2017
    Assignee: University of Washington
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun
  • Molecules that bind CD180, compositions and methods of use
    Patent number: 9416188
    Abstract: Disclosed herein are novel CD180 binding molecules, methods for their identification, and methods for their use.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: August 16, 2016
    Assignee: University of Washington Through Its Center For Commercialization
    Inventors: Jay Chaplin, Martha Hayden-Ledbetter, Jeffrey Ledbetter, Edward A. Clark
  • MOLECULES THAT BIND CD180, COMPOSITIONS AND METHODS OF USE
    Publication number: 20160168257
    Abstract: Disclosed herein are novel CD180 binding molecules, methods for their identification, and methods for their use.
    Type: Application
    Filed: January 12, 2016
    Publication date: June 16, 2016
    Inventors: Jay Chaplin, Martha Hayden-Ledbetter, Jeffrey Ledbetter, Edward A. Clark
  • Molecules that bind CD180, compositions and methods of use
    Patent number: 9260529
    Abstract: The present invention provides novel CD180 binding molecules, methods for their identification, and methods for their use.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: February 16, 2016
    Assignee: The University of Washington Through Its Center For Commercialization
    Inventors: Martha Hayden-Ledbetter, Jeffrey Ledbetter
  • DIAGNOSIS OF CARCINOMAS
    Publication number: 20160033512
    Abstract: The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble and cell surface forms of HE4a polypeptides, including HE4a that is overexpressed in ovarian carcinomas. In particular the invention provides a nucleic acid sequence encoding HE4a, and also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a HE4a polypeptide with a molecule naturally occurring in soluble and/or cell surface form in a sample from such a subject, and by hybridization screening using an HE4a nucleotide sequence, as well as other related advantages.
    Type: Application
    Filed: July 27, 2015
    Publication date: February 4, 2016
    Applicant: PACIFIC NORTHWEST RESEARCH INSTITUTE
    Inventors: Ingegerd Hellstrom, Jeffrey A. Ledbetter, Martha Hayden-Ledbetter
  • Diagnosis of carcinomas
    Patent number: 9090712
    Abstract: The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble and cell surface forms of HE4a polypeptides, including HE4a that is overexpressed in ovarian carcinomas. In particular the invention provides a nucleic acid sequence encoding HE4a, and also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a HE4a polypeptide with a molecule naturally occurring in soluble and/or cell surface form in a sample from such a subject, and by hybridization screening using an HE4a nucleotide sequence, as well as other related advantages.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: July 28, 2015
    Assignee: PACIFIC NORTHWEST RESEARCH INSTITUTE
    Inventors: Ingegerd Hellstrom, Jeffrey A. Ledbetter, Martha Hayden-Ledbetter
  • Therapeutic Nuclease Compositions and Methods
    Publication number: 20150152399
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Application
    Filed: January 19, 2015
    Publication date: June 4, 2015
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun
  • THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS
    Publication number: 20150037871
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Application
    Filed: October 16, 2014
    Publication date: February 5, 2015
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun
  • Therapeutic nuclease compositions and methods
    Patent number: 8937157
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: January 20, 2015
    Assignee: University of Washington
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun
  • Binding domain-immunoglobulin fusion proteins
    Patent number: 8853366
    Abstract: The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a wild-type IgG1, IGA or IgE hinge region polypeptide or a mutant IgG1 hinge region polypeptide having either zero, one or two cysteine residues, and immunoglobulin CH2 and CH3 domains, and that are capable of ADCC and/or CDC while occurring predominantly as polypeptides that are compromised in their ability to form disulfide-linked multimers. The fusion proteins can be recombinantly produced at high express levels. Also provided are related compositions and methods, including cell surface forms of the fusion proteins and immunotherapeutic applications of the fusion proteins and of polynucleotides encoding such fusion proteins.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: October 7, 2014
    Assignee: Emergent Product Development Seattle, LLC
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter
  • Therapeutic nuclease compositions and methods
    Patent number: 8841416
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: September 23, 2014
    Assignee: University of Washington
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun
  • THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS
    Publication number: 20140227269
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Application
    Filed: April 22, 2014
    Publication date: August 14, 2014
    Applicant: University of Washington
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun