Patents by Inventor Martha R. HOTEMA

Martha R. HOTEMA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLE AND IMIDAZOLE COMPOUNDS FOR INHIBITION OF IL-17 AND RORGAMMA
    Publication number: 20240360084
    Abstract: Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and ROR?. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.
    Type: Application
    Filed: April 11, 2024
    Publication date: October 31, 2024
    Inventors: Xin JIANG, Melean VISNICK, Christopher F. BENDER, Gary BOLTON, Bradley CAPRATHE, Chitase LEE, Brian KORNBERG, Patrick O'BRIEN, Martha R. HOTEMA
  • Pyrazole and imidazole compounds for inhibition of IL-17 and RORgamma
    Patent number: 11993574
    Abstract: Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and ROR?. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: May 28, 2024
    Assignee: REATA PHARMACEUTICALS, INC
    Inventors: Xin Jiang, Melean Visnick, Christopher F. Bender, Gary Bolton, Bradley Caprathe, Chitase Lee, Brian Kornberg, Patrick O'Brien, Martha R. Hotema
  • C4-MODIFIED OLEANOLIC ACID DERIVATIVES FOR INHIBITION OF IL-17 AND OTHER USES
    Publication number: 20230250130
    Abstract: Disclosed herein are C4 modified oleanolic acid derivatives of the formula: as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions of these derivatives or analogs, methods for their manufacture, and methods for their use, including for the prevention and treatment of diseases or disorders associated with overproduction of IL-17.
    Type: Application
    Filed: January 4, 2023
    Publication date: August 10, 2023
    Inventors: Melean VISNICK, Xin JIANG, Martha R. HOTEMA, Chitase LEE, Bradley William CAPRATHE, William H. ROARK, Gary L. BOLTON
  • C4-modified oleanolic acid derivatives for inhibition of IL-17 and other uses
    Patent number: 11584775
    Abstract: Disclosed herein are C4 modified oleanolic acid derivatives of the formula: Formula (X) or Formula (XII), as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions of these derivatives or analogs, methods for their manufacture, and methods for their use, including for the prevention and treatment of diseases or disorders associated with overproduction of IL-17.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: February 21, 2023
    Assignee: REATA PHARMACEUTICALS, Inc.
    Inventors: Melean Visnick, Xin Jiang, Martha R. Hotema, Chitase Lee, Bradley William Caprathe, William H. Roark, Gary L. Bolton
  • PYRIMIDINE TRICYCLIC ENONE DERIVATIVES FOR INHIBITION OF ROR-GAMMA AND OTHER USES
    Publication number: 20220135534
    Abstract: Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit ROR? and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.
    Type: Application
    Filed: January 18, 2022
    Publication date: May 5, 2022
    Applicant: REATA PHARMACEUTICALS, INC.
    Inventors: Xin JIANG, Christopher F. BENDER, Melean VISNICK, Martha R. HOTEMA, Zachary S. SHELDON, Chitase LEE, Bradley William CAPRATHE, Gary BOLTON, Brian KORNBERG
  • Pyrimidine tricyclic enone derivatives for inhibition of ROR-gamma and other uses
    Patent number: 11292781
    Abstract: Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit ROR? and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.
    Type: Grant
    Filed: December 16, 2017
    Date of Patent: April 5, 2022
    Assignee: REATA PHARMACEUTICALS, INC.
    Inventors: Xin Jiang, Christopher F. Bender, Melean Visnick, Martha R. Hotema, Zachary S. Sheldon, Chitase Lee, Bradley William Caprathe, Gary Bolton, Brian Kornberg
  • PYRAZOLE AND IMIDAZOLE COMPOUNDS FOR INHIBITION OF IL-17 AND RORGAMMA
    Publication number: 20210292281
    Abstract: Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and ROR?. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.
    Type: Application
    Filed: June 17, 2019
    Publication date: September 23, 2021
    Applicant: REATA PHARMACEUTICALS, INC.
    Inventors: Xin JIANG, Melean VISNICK, Christopher F. BENDER, Gary BOLTON, Bradley CAPRATHE, Chitase LEE, Brian KORNBERG, Patrick O'BRIEN, Martha R. HOTEMA
  • PYRIMIDINE TRICYCLIC ENONE DERIVATIVES FOR INHIBITION OF ROR-GAMMA AND OTHER USES
    Publication number: 20200131148
    Abstract: Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit ROR? and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.
    Type: Application
    Filed: December 16, 2017
    Publication date: April 30, 2020
    Applicant: REATA PHARMACEUTICALS, INC.
    Inventors: Xin JIANG, Christopher F. BENDER, Melean VISNICK, Martha R. HOTEMA, Zachary S. SHELDON, Chitase LEE, Bradley William CAPRATHE, Gary BOLTON, Brian KORNBERG
  • C4-MODIFIED OLEANOLIC ACID DERIVATIVES FOR INHIBITION OF IL-17 AND OTHER USES
    Publication number: 20190153022
    Abstract: Disclosed herein are C4 modified oleanolic acid derivatives of the formula: Formula (X) or Formula (XII), as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions of these derivatives or analogs, methods for their manufacture, and methods for their use, including for the prevention and treatment of diseases or disorders associated with overproduction of IL-17.
    Type: Application
    Filed: September 23, 2016
    Publication date: May 23, 2019
    Inventors: Melean VISNICK, Xin JIANG, Martha R. HOTEMA, Chitase LEE, Bradley William CAPRATHE, William H. ROARK, Gary L. BOLTON