Abstract: It has been discovered that the neuropeptides secretin, oxytocin and vasopressin can be administered as therapeutic agents alone or in various combinations to treat dry eye and dry mouth. Based on these discoveries and the results described, certain claims are directed to pharmaceutical compositions formulated for topical oral or ophthalmic use comprising therapeutically or prophylactically effective amounts of the neuropeptides secretin, oxytocin and secretin alone, or in various combinations.

Abstract: The present invention provides compositions and methods for preventing and treating gastrointestinal disorders by administering to a subject an effective amount of secretin either alone or in combination with an effective amount of oxytocin. The invention also provides compositions and methods for preventing and treating central nervous system disorders by administering to a subject an effective amount of secretin in combination with an effective amount of oxytocin. The invention further provides compositions and methods for treating and preventing a variety of autoimmune diseases by administering to a subject an effective amount of secretin in combination with an effective amount of oxytocin. Additionally, the invention provides compositions and methods for preventing and treating pain by administering to a subject using a combination of an effective amount of secretin and an effective amount of oxytocin.

Abstract: A pilot operated valve assembly including a valve body having a pressurized air supply inlet port in communication with a source of pressurized air and at least one cylinder passage. A main valve bore extends axially within the valve body and a main valve member is movable between predetermined positions within the main valve bore to selectively direct pressurized air from the inlet port through at least one cylinder passage. A pilot valve bore is formed within the main valve member and extends coaxially relative to the main valve bore. A pair of short pilot cylinder ports spaced apart from one another extend between the main valve bore and the pilot valve bore. A pilot valve member is movable between predetermined positions within the pilot valve bore to selectively direct air from the pilot valve bore through alternating ones of the pilot cylinder ports to act upon the main valve member thereby moving the main valve member between predetermined positions.