Patents by Inventor Martha Zeiger

Martha Zeiger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THYROID CANCER-SPECIFIC BIOMARKER PANEL
    Publication number: 20230323465
    Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods directed to a thyroid cancer-specific biomarker panel. In a specific embodiment, a methods for identifying at thyroid tumor/nodule as benign or malignant comprises the steps of (a) measuring expression, in a sample obtained from the patient, by real-time quantitative polymerase chain reaction (RT-PCR) of at least three splice variant markers of a panel comprising high mobility group AT-hook 2 (HMGA2), transcript variant 1; PLAG1 zine finger (PLAG1), transcript variant 1; kallikrein related peptidase 7 (KLK7), transcript variant 1; fibronectin type III domain containing 4 (FNDC4); and cadherin 3 (CDH3), transcript variant 1; and (b) identifying the tumor as benign or malignant based on the measured expression levels of the panel of splice variant markers as compared to a control.
    Type: Application
    Filed: June 25, 2021
    Publication date: October 12, 2023
    Inventors: Christopher B. Umbricht, Yongchun Wang, Martha A. Zeiger
  • COMPOSITIONS AND METHODS FOR CHARACTERIZING THYROID NEOPLASIA
    Publication number: 20140371096
    Abstract: The present invention features compositions and methods for characterizing thyroid lesions (e.g., benign follicular adenomas (FAs), papillary thyroid carcinomas (PTC) and follicular variant papillary thyroid carcinomas (FVPTCs)).
    Type: Application
    Filed: December 10, 2012
    Publication date: December 18, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Christopher B. Umbricht, Leslie Cope, Yan Liu, Martha A. Zeiger
  • COMPOSITIONS AND METHODS FOR CHARACTERIZING AND TREATING NEOPLASIA
    Publication number: 20120115804
    Abstract: The invention features compositions and methods for characterizing the methylation status of the Vitamin D Receptor (VDR) in neoplasia (e.g., breast carcinoma), selecting an appropriate therapy, and treating the neoplasia (e.g., breast carcinoma).
    Type: Application
    Filed: March 10, 2010
    Publication date: May 10, 2012
    Applicant: The John Hopkins University
    Inventors: Radharani Marik, Christopher B. Umbricht, Martha A. Zeiger
  • METHOD FOR DIAGNOSING THE STAGE OF A THYROID TUMOR
    Publication number: 20110177971
    Abstract: The present invention relates to the use of genes differentially expressed in benign thyroid lesions and malignant thyroid lesions for the diagnosis and staging of thyroid cancer.
    Type: Application
    Filed: February 10, 2011
    Publication date: July 21, 2011
    Inventors: Steven K. Libutti, Chiara Mazzanti, Martha Zeiger, Christopher Umbricht
  • Diagnostic tool for diagnosing benign versus malignant thyroid lesions
    Patent number: 7901881
    Abstract: The present invention relates to the use of genes differentially expressed in benign thyroid lesions and malignant thyroid lesions for the diagnosis and staging of thyroid cancer.
    Type: Grant
    Filed: April 11, 2005
    Date of Patent: March 8, 2011
    Assignees: The United States of America as represented by the Department of Health and Human Services, The John Hopkins University
    Inventors: Steven K. Libutti, Chiara Mazzanti, Martha Zeiger, Christopher Umbricht
  • Diagnostic Tool For Diagnosing Benign Versus Malignant Thyroid Lesions
    Publication number: 20080145841
    Abstract: The present invention relates to the use of genes differentially expressed in benign thyroid lesions and malignant thyroid lesions for the diagnosis and staging of thyroid cancer.
    Type: Application
    Filed: April 11, 2005
    Publication date: June 19, 2008
    Inventors: Steven K. Libutti, Chiara Mazzanti, Martha Zeiger, Christopher Umbricht