Abstract: An intravascular blood flow sensing system is provided. The system includes an intravascular catheter or guidewire with a flow sensor that obtains flow data of blood flow within a blood vessel. The system includes a processor circuit that communicates with the intravascular catheter or guidewire. The processor circuit receives the flow data from the intravascular catheter or guidewire, determine a plurality of values based on the flow data, and outputs a plot of the plurality of values to a display. The plot includes peak associated with coronary reactivity testing (CRT). The processor circuit can also automatically change between a louder volume and a softer volume for audio output of the flow data. The processor circuit can additional communicate with a device other than the flow sensor (e.g., ECG, pressure sensor, etc.), and graphical representations of the flow data and the data received from the other device can be independent scaled.

Abstract: An apparatus for analyzing coronary vessels and a corresponding method are provided in which simulated pullback data obtained from (non-invasively) acquired diagnostic images is co-registered with invasively acquired intravascular pullback data and the co-registration is used to identify disparities in the pullback data obtained using the two modalities. These disparities allow for deriving further information about the vessel geometry and/or the blood flow through the vessel. They may therefore be used to improve the physiological model.

Abstract: A method and apparatus for analyzing diagnostic image data are provided in which correspondence detection between a first diagnostic image and a second diagnostic image of a vessel of interest in a patients vasculature is performed on the basis of at least one functional parameter by matching the one or more values of said functional parameter at particular positions along the vessel of interest as shown in the first diagnostic image and the second diagnostic image to one another, thereby determining a correlation between the positions in the basis of said functional parameter values rather than solely the vessel geometry.

Abstract: An apparatus for assessing a patient-s vasculature is provided which is adapted to derive a physiological model of the vasculature including a geometric model and a fluid dynamics model of a vessel of interest and a dynamics measure indicative of a contrast agent dynamics through the vasculature from a plurality of diagnostic images and to analyze the at least one dynamics measure as the function of time such as to adjust at least one boundary condition of the fluid dynamics model.

Abstract: A method and apparatus for selecting one or more diagnostic images to generate a physiological model are provided in which a set of candidate images is determined for review by a user, in particular by a physician. The candidate images are hereby determined using one or more target measures, such as a density measure, a motion measure, a deviation measure or the like, that have been derived for each diagnostic image of an X-ray angiography series and by analyzing said target measure. Subsequently, a suitability score that is based on the requirements of the physiological model that shall be generated from the selected candidate images is assigned to each candidate image.

Abstract: An apparatus for assessing a vessel of interest and a corresponding method are provided in which the modeling of the hemodynamic parameters using a fluid dynamics model can be verified by deriving feature values from the segmented vessel of interest and inputting these feature values into a classifier. The classifier may then determine, based on the feature values whether the segmentation has been performed from proximal to distal, from distal to proximal or cannot be determined from the provided data. An incorrect segmentation order can thus be identified and potentially be corrected, thereby avoiding inaccurate simulation results.

Abstract: An apparatus for assessing a coronary vasculature and a corresponding method are provided which allow to globally assess a coronary artery disease directly from the contrast agent dynamics as derived from diagnostic images acquired using an invasive medical imaging modality by following the time course of the area occupied by the vessels in the diagnostic images.

Abstract: An apparatus for analyzing coronary vessels and a corresponding method are provided in which simulated pullback data obtained from (non-invasively) acquired diagnostic images is co-registered with invasively acquired intravascular pullback data and the co-registration is used to identify disparities in the pullback data obtained using the two modalities. These disparities allow for deriving further information about the vessel geometry and/or the blood flow through the vessel. They may therefore be used to improve the physiological model.

Abstract: An apparatus is provided which improves the evaluation of a patient's vasculature by applying a correction to invasively acquired intravascular measurement data of a vessel of interest on the basis of archived patient data of said patient from a patient database. By correcting the measurement data, co-morbidities of the patient which may influence the intravascular measurement results are accounted for.

Abstract: An apparatus for modeling coronary physiology and a corresponding method are provided in which at least one diagnostic image and intravascular imaging data are co-registered and used in combination to retrieve more accurate, patient-specific vessel parameters to be used in the modeling of the vessel geometry and the fluid dynamics of the blood flow.

Abstract: An apparatus for analyzing a vasculature of a patient and a corresponding method are provided in which a plurality of simulated hemodynamic parameter values obtained from (non-invasively) acquired diagnostic images are compared to at least one intravascular hemodynamic parameter value acquired during an invasive measurement in a vessel of interest in the vasculature. The comparison allows to uniquely determine the vessel of interest. Based on this information, the assessment of the disease and the potential treatment planning may be improved.

Abstract: Devices, systems, and methods for evaluating a physiological condition of a vessel are disclosed. In an embodiment, a medical system is disclosed. One embodiment of the medical system comprises a medical processing unit in communication with a first pressure sensor, a second pressure sensor, and a radiographic imaging source configured to obtain radiographic images of at least one intravascular instrument positioned within a body lumen. The medical processing unit is configured to: receive the radiographic images obtained by the radiographic imaging source; detect, using the radiographic images, when the first pressure sensor is in a pre-determined orientation with respect to the second pressure sensor; and automatically initiate normalization of the first pressure sensor and the second pressure sensor in response to detecting that the first pressure sensor is in the pre-determined orientation with respect to the second pressure sensor.