Abstract: According to various embodiments, a system for, and method of, predicting and remediating malware threats in an electronic computer network, is provided. The disclosed techniques include storing in an electronic persistent storage library data representing a plurality of malware threats, randomizing, by a computer-implemented evolution engine communicatively coupled to the electronic persistent storage library, data representing malware threats to generate data representing randomized malware threats, and evaluating, by a computer-implemented evaluation engine communicatively coupled to an output of the evolution engine and to the electronic persistent storage library, the data representing the randomized malware threats, where the evaluation engine adds data representing positively evaluated randomized malware threats to the library for proactive detection of future malware threats in the electronic computer network.

Abstract: According to various embodiments, a system for, and method of, predicting and remediating malware threats in an electronic computer network, is provided. The disclosed techniques include storing in an electronic persistent storage library data representing a plurality of malware threats, randomizing, by a computer-implemented evolution engine communicatively coupled to the electronic persistent storage library, data representing malware threats to generate data representing randomized malware threats, and evaluating, by a computer-implemented evaluation engine communicatively coupled to an output of the evolution engine and to the electronic persistent storage library, the data representing the randomized malware threats, where the evaluation engine adds data representing positively evaluated randomized malware threats to the library for proactive detection of future malware threats in the electronic computer network.

Abstract: The present invention relates to bis(4-demethoxydaunorubicin)dihydrazone of the formula ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen or alkyl having from 1 to 4 carbon atoms and X represents(a) alkylene having from 3 to 20 carbon atoms and optionally substituted by one or more hydroxy and/or primary amino groups, or(b) alkylene optionally interrupted by one or more secondary amino groups, the total number of carbon and nitrogen atoms in the resultant chain being 3 to 20and to pharmacologically acceptable salts thereof which are potent inhibitors of neoplastic disease and are also useful as antiviral agents.

Abstract: A new group of compounds having an enhanced ability to inhibit nucleic acid functions have been prepared. These drugs are bis-anthracyclines wherein two anthracycline molecules are linked through their C-13 carbon atoms by amino and/or hydroxy-dicarboxylic acids and their derivatives to form the bis-compounds. Such bis-anthracyclines may be even more effectively delivered to selected sites in a mammalian organism by incorporating the same within uniformly sized liposomes.

Abstract: Modified actinomycin compounds that incorporate azetidine in the polypeptide component of the actinomycin molecule are disclosed. These compounds are called azetomicins and specifically incorporate an azetidine derivative in the 3' peptide position in at least one of the two polypeptides normally present in actinomycins. The azetomicins are produced by bio-synthetic means from Streptomyces antibioticus that are cultured on a medium including azetidine-2 carboxylic acid and derivatives thereof.

Abstract: Modified actinomycin compounds that incorporate azetidine in the polypeptide component of the actinomycin molecule are disclosed. These compounds are called Azetomicins and specifically incorporate an azetidine derivative in the 3' peptide position in at least one of the two polypeptides normally present in actinomycins. The Azetomicins are produced by bio-synthetic means from Streptomyces antibioticus that are cultured on a medium including azetidine-2 carboxylic acid and derivatives thereof.