Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: A container (10) comprising a wall arrangement (12) defining a load receiving space (16), and a support member (14) attached on the wall arrangement (12), the support member (14) being movable between a support position and a non-support position, wherein, in the support position, the support member (14) extends at least partially across the load receiving space (16), the support member having a planar portion (30) to support a further container (10) in a stacked condition on the container (10).

Abstract: A ratchet spool (59) for use in a winding assembly (16) is disclosed. The ratchet spool (59) is rotatable about a principal axis (61). The ratchet spool (59) comprises a main part (20) and a plurality of ratchet teeth (60) arranged circumferentially around the main part (20). The ratchet teeth (60) are engageable by a ratchet arrangement (18) for driving the ratchet spool (59) in a driving direction about said principal axis (61). The ratchet spool (59) also has a drive formation (21) for driving the ratchet spool (59) in said driving direction.

Abstract: A container (10) comprising a wall arrangement (20) defining an internal region (14). The container (10) further comprises a support arrangement (36) attached to the wall arrangement (20). The support arrangement (36) is arrangeable in a support position in which the support arrangement (36) extends across the internal region (14). The support arrangement (36) is also arrangeable in a non-support position in which the support arrangement (36) extends along the wall arrangement (20) within the internal region (14) in engagement with the wall arrangement (20). The support arrangement (36) is movable between the support and the non-support positions.

Abstract: A brake operating arrangement (18) comprises a cam member (22) operable on a brake mechanism (36) for braking a wheel (34). The brake mechanism (36) is movable between a braking condition and a non-braking condition. The cam member (22) is rotatable to move the brake mechanism (36) to the braking condition. The brake operating arrangement (18) further includes a drive member (44) movable in drive and return directions; and a ratchet mechanism (46) to rotate the cam member (22) when the drive member (44) is moved in the drive direction. The ratchet mechanism (46) is connected to the drive member (44) and the cam member (22).

Abstract: A dolly (10) comprises a body (12) having an upwardly projecting first locating formation (20) for locating a further dolly thereon in a stacked condition of said dollies. The body (12) has a second locating formation (21) for stacking the dolly (10) on a further dolly in a stacked condition of said dollies. The first locating formation (20) is engageable with a second locating formation on the further dolly stacked on the first mentioned dolly, and the second locating formation (21) is engageable with a first locating formation of the further dolly on which the first mentioned dolly (10) is stacked.

Abstract: A tool for thermoforming a container having a base and an upstanding sidewall walls or walls. The tool includes a mould having a profile shaped to form the exterior shape of the container and a plug adapted to be inserted in the mould to define the interior of the container. The plug has a lower face adapted to define the profile of the base of the container. The profile of the lower face of the plug has at least one groove therein defining, in use, a rib upstanding in the interior of the base of the container.

Abstract: A dolly (10) comprises a body (12) having an upwardly projecting first locating formation (20) for locating a further dolly thereon in a stacked condition of said dollies. The body (12) has a second locating formation (21) for stacking the dolly (10) on a further dolly in a stacked condition of said dollies. The first locating formation (20) is engageable with a second locating formation on the further dolly stacked on the first mentioned dolly, and the second locating formation (21) is engageable with a first locating formation of the further dolly on which the first mentioned dolly (10) is stacked.

Abstract: A method for forming a squirrel cage rotor includes stacking a plurality of coated laminates to form a stacked laminate core preform. The stacked laminate core preform defines a plurality of open cavities. Each coated laminate of the plurality of coated laminates includes a laminate coated with a precursor layer. The precursor layer includes a binder and glass particles. The method further includes firing the stacked laminate core preform at a temperature above the softening point of the glass particles to form a low porosity rotor core. The method further includes casting a conductive material into the plurality of open cavities formed in the rotor core to define a conductive squirrel cage structure in the low porosity rotor core.

Abstract: The present invention generally relates to a continuous monitoring system and method for monitoring the loads in a support leg of an offshore drilling rig through a remote unit mounted to the climbing pinion shaft of a jacking drive system when the brake is engaged.

Abstract: Dry pumps are used to pump a variety of gas mixtures from the semiconductor industry. The present invention provides a liquid ring pump located between the dry pump and an abatement device to remove soluble corrosive materials prior to the exhaust gases entry to the abatement device, the work fluid exhausted from the liquid ring pump being separated from the gas prior to entry to the abatement device.

Abstract: The invention relates to an apparatus and related method for cleaning vessel hulls and other subsea structures at sea. In an embodiment, a hull cleaning system comprises a housing defining an interior void; a multifunction bar; a propulsion system; a power system; a positioning system; a water pump operatively connected to the power system; a high flow manifold operatively in fluid communication with the water pump; a hull cleaner; and a suction device configured to selectively adhere the hull cleaning system to a hull.

Abstract: The present disclosure generally relates to an integrated wireless data system and method for mounting the system on one or more components within a vehicle wheel hub assembly for measuring operational data relating to the condition or status of a brake rotor or other components within a wheel hub assembly, where the integrated wireless data system rotates with the vehicle wheel.

Abstract: Disclosed herein are embodiments of a system for treating water. The system comprises one or more inlets for introducing biochar and polyamine to the water, such as a biochar inlet and a polyamine inlet, or a biochar/polyamine mixture inlet. The system may optionally also include a metal salt inlet, ozone inlet, an additional organic carbon compound inlet, or any combination thereof. The biochar and polyamine may optionally be premixed prior to addition to the water. The system also comprises a filtration device, such as a reactive filtration device. The system produces a treated water stream and a reject stream, which may be further separated into a recycled water stream and a solid product. The solid product may be suitable as a soil amendment for application to agricultural land, or for recycling. A method for using the system to treat water, particularly nitrate-contaminated water, also is disclosed.

Abstract: A securing device (10) for securing an article is disclosed. The securing device comprises a main shaft portion (14) and a securing portion (20) on the main shaft portion. The securing portion is a substantially helical elongate portion defining a central space (20A). Holding devices (312, 340), drive transmission devices (102, 202) and indicating devices (332) can be used with the securing device.

Abstract: Dry pumps are used to pump a variety of gas mixtures from the semiconductor industry. The present invention provides a liquid ring pump located between the dry pump and an abatement device to remove soluble corrosive materials prior to the exhaust gases entry to the abatement device, the work fluid exhausted from the liquid ring pump being separated from the gas prior to entry to the abatement device.

Abstract: The present invention generally relates to a continuous monitoring system and method for monitoring the loads in a support leg of an offshore drilling rig through a remote unit mounted to the climbing pinion shaft of a jacking drive system when the brake is engaged.

Abstract: The present disclosure generally relates to an integrated wireless data system and method for mounting the system on one or more components within a vehicle wheel hub assembly for measuring operational data relating to the condition or status of a brake rotor or other components within a wheel hub assembly, where the integrated wireless data system rotates with the vehicle wheel.

Abstract: A stiffening assembly (10) for stiffening an article (12) is disclosed. The stiffening assembly comprises a plurality of main modules (14) arrangeable on the article. Each main module comprises a body (16) and a receiving formation (28) on the body for receiving a portion of the article therethrough. The stiffening assembly further includes a fastening arrangement for fastening the main modules to one another. The fastening arrangement comprises first and second fastening formations (24, 26).

Abstract: A securing device (10) for securing an article is disclosed. The securing device comprises a main shaft portion (14) and a securing portion (20) on the main shaft portion. The securing portion is a substantially helical elongate portion defining a central space (20A). Holding devices (312, 340), drive transmission devices (102, 202) and indicating devices (332) can be used with the securing device.