Patents by Inventor Martin A. Drinan
Martin A. Drinan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11958863Abstract: The present disclosure includes compounds, kits, and assay procedures for use in determining the levels of certain types of drugs in samples that contain specific binding proteins for the drugs. The present disclosure includes analog compounds useful for displacing the drugs from their endogenous binding proteins, and kits including same, as well as methods that utilize these displacers as binding competitors in pharmaceutical assays.Type: GrantFiled: October 25, 2019Date of Patent: April 16, 2024Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Tie Wei, Zhu Teng, Martin Drinan, Jie Li
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Publication number: 20220024946Abstract: Compositions comprising binding competitors that can be used in assays for macrophilin-binding pharmaceuticals in samples are disclosed, as well as kits containing same and methods of use thereof.Type: ApplicationFiled: October 25, 2019Publication date: January 27, 2022Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Tie Wei, Zhu Teng, Martin Drinan, Jie Li
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Publication number: 20210247398Abstract: Kits containing a chemiluminescent detection system and microfluidics devices and methods for determining the concentration of biotin in a sample are disclosed. The kits, microfluidics devices, and methods utilize a sensitizer capable of generating singlet oxygen in its excited state and having avidin or an analog thereof directly or indirectly bound thereto, as well as a singlet oxygen-activatable chemiluminescent compound having biotin or an analog thereof directly or indirectly bound thereto.Type: ApplicationFiled: July 24, 2019Publication date: August 12, 2021Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Tie Q. Wei, Zhu Teng, Xiaodong Liu, Martin Drinan
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Patent number: 10399938Abstract: The present invention discloses compositions that comprise compounds relating to vitamin D. These compounds are useful for assays in the determination and distinguishing of certain 3-epimeric 25 hydroxyvitamin D and non-epimeric 25 hydroxyvitamin D. The compositions of the present invention may be used for example as immunogens used to develop antibodies to certain vitamin D compounds or conjugates used in assays for certain vitamin D compounds or used as a solid phase reagent in assays. The composition comprises a compound of one or more of the generic formula (R1)p-(L)q-Z.Type: GrantFiled: September 19, 2018Date of Patent: September 3, 2019Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Zhu Teng, Qimu Liao, Manoj Sharma, Martin A. Drinan, Tie Quan Wei
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Patent number: 10203344Abstract: Compounds include carbamate derivatives of vitamin D including vitamin D3 and vitamin D2. The compounds are useful in methods and kits for determining the presence and/or amount of vitamin D including vitamin D analogs and metabolites thereof in a sample suspected of containing the same.Type: GrantFiled: December 16, 2015Date of Patent: February 12, 2019Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Zhu Teng, Roland Janzen, Martin A. Drinan
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Publication number: 20190016677Abstract: Compounds include compounds of the Formula I, namely, (R1)p-(L)q-Z wherein R1, L, p and q are as defined herein.Type: ApplicationFiled: September 19, 2018Publication date: January 17, 2019Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Zhu Teng, Qimu Liao, Manoj Sharma, Martin A. Drinan, Tie Quan Wei
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Patent number: 10106498Abstract: This invention relates to compositions, methods and kits for determining the presence and/or amount of vitamin D analytes, including vitamin D isomers, and metabolites thereof in a sample suspected of containing the same. Compounds include compounds of the Formula I, namely, (R1)p-(L)q-Z wherein R1, L, p and q are as defined herein. These compounds are capable of binding specifically to corresponding antibodies. Compounds and antibodies in accordance with the principles described herein can have therapeutic activity. These compounds may be administered in therapeutically effective amount, which is an amount to provide treatment of a particular disease state associated with vitamin D. Administration of the examples of compounds in accordance with the principles described herein can be by means of any of the accepted modes of administration for agents that serve similar utilities.Type: GrantFiled: June 22, 2015Date of Patent: October 23, 2018Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Zhu Teng, Qimu Liao, Manoj Sharma, Martin A. Drinan, Tie Quan Wei
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Publication number: 20180180623Abstract: Compositions are disclosed that include a support having on a surface thereof at least an inner polysaccharide layer and an outer polysaccharide layer. The outer polysaccharide layer has pendant moieties each comprising a terminal amine functionality. The point of linkage of the pendant moiety to the outer polysaccharide layer does not comprise an amide bond. The composition may be employed in a method of conjugating a member of a specific binding pair to a particle. The method comprises reacting the terminal amine functionality of the composition with the member of the specific binding pair, which comprises an amine-reactive functionality.Type: ApplicationFiled: February 19, 2018Publication date: June 28, 2018Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Zhu Teng, Liping Geng, Martin Drinan
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Patent number: 9804176Abstract: Methods include determining an amount of an epimeric vitamin D analyte in a sample suspected of containing the epimeric vitamin D analyte. A combination is provided in an assay medium that includes the sample and a vitamin D epimer antibody that is specific for the epimeric vitamin D analyte. The assay medium is incubated under conditions for binding of the vitamin D epimer antibody to the epimeric vitamin D analyte to form an epimeric vitamin D antibody-bound complex. The amount of the epimeric vitamin D antibody-bound complex is determined and related to the amount of epimeric vitamin D analyte in the sample.Type: GrantFiled: June 22, 2015Date of Patent: October 31, 2017Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Tie Quan Wei, Zhu Teng, Tatiana Mareeva, Jie Li, Martin A. Drinan, Izak Bahar, Manoj Sharma
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Patent number: 9726681Abstract: Methods of detecting Cortisol in samples suspected of containing Cortisol are disclosed that utilize conjugates of 11-a-cortisol linked at the 3-position to an assay molecule. In addition, compounds are disclosed that have the formula: (structure) wherein L is a linking group and X is as further defined herein.Type: GrantFiled: August 6, 2014Date of Patent: August 8, 2017Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Zhu Teng, Lauren Seiple, Martin Drinan
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Publication number: 20170153254Abstract: Methods include determining an amount of an epimeric vitamin D analyte in a sample suspected of containing the epimeric vitamin D analyte. A combination is provided in an assay medium that includes the sample and a vitamin D epimer antibody that is specific for the epimeric vitamin D analyte. The assay medium is incubated under conditions for binding of the vitamin D epimer antibody to the epimeric vitamin D analyte to form an epimeric vitamin D antibody-bound complex. The amount of the epimeric vitamin D antibody-bound complex is determined and related to the amount of epimeric vitamin D analyte in the sample.Type: ApplicationFiled: June 22, 2015Publication date: June 1, 2017Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Tie Quan Wei, Zhu Teng, Tatiana Mareeva, Jie Li, Martin A. Drinan, Izak Bahar, Manoj Sharma
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Publication number: 20170114012Abstract: This invention relates to compositions, methods and kits for determining the presence and/or amount of vitamin D analytes, including vitamin D isomers, and metabolites thereof in a sample suspected of containing the same. Compounds include compounds of the Formula I, namely, (R1)p-(L)q-Z wherein R1, L, p and q are as defined herein. These compounds are capable of binding specifically to corresponding antibodies. Compounds and antibodies in accordance with the principles described herein can have therapeutic activity. These compounds may be administered in therapeutically effective amount, which is an amount to provide treatment of a particular disease state associated with vitamin D. Administration of the examples of compounds in accordance with the principles described herein can be by means of any of the accepted modes of administration for agents that serve similar utilities.Type: ApplicationFiled: June 22, 2015Publication date: April 27, 2017Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Zhu Teng, Qimu Liao, Manoj Sharma, Martin A. Drinan, Tie Quan Wei
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Publication number: 20160178650Abstract: Methods of detecting Cortisol in samples suspected of containing Cortisol are disclosed that utilize conjugates of 11-?-cortisol linked at the 3-position to an assay molecule. In addition, compounds are disclosed that have the formula: (structure) wherein L is a linking group and X is as further defined herein.Type: ApplicationFiled: August 6, 2014Publication date: June 23, 2016Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.Inventors: Zhu Teng, Lauren Seiple, Martin Drinan
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Publication number: 20160103141Abstract: Compounds include carbamate derivatives of vitamin D including vitamin D3 and vitamin D2. The compounds are useful in methods and kits for determining the presence and/or amount of vitamin D including vitamin D analogs and metabolites thereof in a sample suspected of containing the same.Type: ApplicationFiled: December 16, 2015Publication date: April 14, 2016Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Zhu Teng, Roland Janzen, Martin A. Drinan
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Patent number: 9244083Abstract: Compounds include carbamate derivatives of vitamin D including vitamin D3and vitamin D2. The compounds are useful in methods and kits for determining the presence and/or amount of vitamin D including vitamin D analogs and metabolites thereof in a sample suspected of containing the same.Type: GrantFiled: November 30, 2012Date of Patent: January 26, 2016Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Zhu Teng, Roland Janzen, Martin A. Drinan
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Publication number: 20150072438Abstract: Compositions are disclosed that include a support having on a surface thereof at least an inner polysaccharide layer and an outer polysaccharide layer. The outer polysaccharide layer has pendant moieties each comprising a terminal amine functionality. The point of linkage of the pendant moiety to the outer polysaccharide layer does not comprise an amide bond. The composition may be employed in a method of conjugating a member of a specific binding pair to a particle. The method comprises reacting the terminal amine functionality of the composition with the member of the specific binding pair, which comprises an amine-reactive functionality.Type: ApplicationFiled: April 11, 2013Publication date: March 12, 2015Applicant: Siemens Healthcare Diagnostic Inc.Inventors: Zhu Teng, Liping Geng, Martin Drinan
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Publication number: 20140154700Abstract: Compounds include carbamate derivatives of vitamin D including vitamin D3 and vitamin D2. The compounds are useful in methods and kits for determining the presence and/or amount of vitamin D including vitamin D analogs and metabolites thereof in a sample suspected of containing the same.Type: ApplicationFiled: November 30, 2012Publication date: June 5, 2014Inventors: Zhu Teng, Roland Janzen, Martin A. Drinan