Patents by Inventor Martin A. Smith
Martin A. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10429499Abstract: The present invention provides a sensor system for measuring a parameter (e.g. volume, temperature or pressure) of a target, the system comprising a diaphragm, a sensor for measuring the axial spacing between the sensor and the diaphragm, and an axially adjustable mount. The mount has a first axial end for mounting the diaphragm which is axially movable relative to the sensor and an opposing, second axial end which is axially fixed relative to the sensor. The diaphragm and mount define a chamber for receiving the target or for being received within the target. In use, the axial spacing between the first axial end and the second axial end of the mount and thus the axial spacing between the diaphragm and sensor varies as a result of a change in the parameter differential across the diaphragm.Type: GrantFiled: February 21, 2017Date of Patent: October 1, 2019Assignee: ROLLS-ROYCE PLCInventors: Francis Bridge, Martin A Smith, Bob E Wilson
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Publication number: 20170261607Abstract: The present invention provides a sensor system for measuring a parameter (e.g. volume, temperature or pressure) of a target, the system comprising a diaphragm, a sensor for measuring the axial spacing between the sensor and the diaphragm, and an axially adjustable mount. The mount has a first axial end for mounting the diaphragm which is axially movable relative to the sensor and an opposing, second axial end which is axially fixed relative to the sensor. The diaphragm and mount define a chamber for receiving the target or for being received within the target. In use, the axial spacing between the first axial end and the second axial end of the mount and thus the axial spacing between the diaphragm and sensor varies as a result of a change in the parameter differential across the diaphragm.Type: ApplicationFiled: February 21, 2017Publication date: September 14, 2017Applicant: ROLLS-ROYCE plcInventors: Francis BRIDGE, Martin A. SMITH, Bob E. WILSON
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Patent number: 9090863Abstract: Systems are provided for convenient and sterile isolation, collection, and seeding of cells onto a scaffold or tissue graft. The systems may be closed. Methods for use of the disclosed systems for isolation, collection and seeding of cells and generation of tissue engineered vascular grafts are also provided. The systems may be supplied in kits for efficient and expeditious use.Type: GrantFiled: May 17, 2010Date of Patent: July 28, 2015Assignees: PALL CORPORATION, YALE UNIVERSITYInventors: Christopher Breuer, Edward L. Snyder, Keru O. Shafi, Martin A. Smith
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Publication number: 20110281358Abstract: Systems are provided for convenient and sterile isolation, collection, and seeding of cells onto a scaffold or tissue graft. The systems may be closed. Methods for use of the disclosed systems for isolation, collection and seeding of cells and generation of tissue engineered vascular grafts are also provided. The systems may be supplied in kits for efficient and expeditious use.Type: ApplicationFiled: May 17, 2010Publication date: November 17, 2011Applicants: PALL CORPORATION, YALE UNIVERSITYInventors: Christopher Breuer, Edward L. Snyder, Keru O. Shafi, Martin A. Smith
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Publication number: 20090043087Abstract: This invention relates to methods for rapid nucleic acid purification from sources heavily contaminated with high particulate material, such as cellular debris, and solids, including suspended solids. In particular, this invention provides methods for rapid, quantifiable recovery and purification of nucleic acids from a variety of sources heavily contaminated with solids, such as small organisms, tissue samples, samples of blood found on soil, or samples of washing from foods, which are frequently difficult sources for nucleic acid isolation due to their propensity to clog filters and columns. A device and kit are also provided.Type: ApplicationFiled: March 12, 2008Publication date: February 12, 2009Inventors: James C. Davis, Martin A. Smith, Frank D. Igoe, Marcela A. Vera-Garcia
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Patent number: 6958392Abstract: A method for isolating nucleic acid which comprises: (a) applying a sample comprising cells containing nucleic acid to a filter, whereby the cells are retained as a retentate and contaminants are removed; (b) lysing the retentate from step (a) while the retentate is retained by the filter to form a cell lysate containing the nucleic acid; (c) filtering the cell lysate with the filter to retain the nucleic acid and remove remaining cell lysate; (d) optionally washing the nucleic acid retained by the filter; and (e) eluting the nucleic acid, wherein the filter composition and dimensions are selected so that the filter is capable of retaining the cells and the nucleic acid. Additionally, there is provided a substrate for lysing cells and purifying nucleic acid having a matrix and a coating and an integrity maintainer for maintaining the purified nucleic acid.Type: GrantFiled: July 18, 2001Date of Patent: October 25, 2005Assignee: Whatman, Inc.Inventors: Galina N. Fomovskaia, Martin A. Smith, Mikhail A. Fomovsky, Neil J. Butt
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Patent number: 6881543Abstract: The invention relates to methods, a kit, and an apparatus for detecting and analyzing genetic material from a biological sample. The method can be used to analyze samples from a wide variety of sources, including tissues, blood, plasma, sera, mucus, urine, saliva, sweat, semen, and cultures, as well as analyzing samples of contaminated water, food, beverages, and other items.Type: GrantFiled: November 14, 2001Date of Patent: April 19, 2005Assignee: Whatman, Inc.Inventors: Richard Philpott, Martin A. Smith, Frank D. Igoe, James C. Davis
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Patent number: 6670128Abstract: The present invention provide methods for utilizing spent leukodepletion filter devices as a source of material for the isolation and analysis of genomic DNA (gDNA), including polymorphism, genotyping, and pharmacogenomic studies. Cellular retentate with the filter contains leukocytes, which are lysed to release the nuclei. The nuclei are lysed or ruptured to release genomic DNA, which is then isolated and used for subsequent analysis.Type: GrantFiled: August 15, 2001Date of Patent: December 30, 2003Assignee: Whatman, Inc.Inventors: Martin A. Smith, Galina N. Fomovskaia, Mikhail A. Fomovsky, Neil J. Butt, Matthew Baker
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Patent number: 6645717Abstract: A medium for storage and subsequent analysis of a genetic material includes a support for immobilizing the genetic material thereon and allowing subsequent elution of the genetic material therefrom and a coating functionally associated with the support for enabling cellular lysis and releasing the genetic material from the lysed cells while stabilizing the immobilized released genetic material. A method of storing the genetic material and subsequently analyzing the genetic material includes the steps of immobilizing the genetic material on a support while enabling cellular lysis and release of genetic material from the lysed cells and stabilizing the immobilized released genetic material on the support. The genetic material is then eluted to generate a soluble genetic material fraction. The eluted genetic material can be analyzed.Type: GrantFiled: February 18, 2000Date of Patent: November 11, 2003Assignee: Whatman, Inc.Inventors: Martin A. Smith, Mridula Iyer, Daqing Qu, James C. Davis
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Publication number: 20030091989Abstract: This invention relates to methods for rapid nucleic acid purification from sources heavily contaminated with high particulate material, such as cellular debris, and solids, including suspended solids. In particular, this invention provides methods for rapid, quantifiable recovery and purification of nucleic acids from a variety of sources heavily contaminated with solids, such as small organisms, tissue samples, samples of blood found on soil, or samples of washing from foods, which are frequently difficult sources for nucleic acid isolation due to their propensity to clog filters and columns. A device and kit are also provided.Type: ApplicationFiled: August 20, 2002Publication date: May 15, 2003Applicant: Whatman, Inc.Inventors: James C. Davis, Martin A. Smith, Frank D. Igoe, Marcela A. Vera-Garcia
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Publication number: 20020150907Abstract: A method for isolating nucleic acid which comprises:Type: ApplicationFiled: July 18, 2001Publication date: October 17, 2002Inventors: Galina N. Fomovskaia, Martin A. Smith, Mikhail A. Fomovsky, Neil J. Butt
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Publication number: 20020090623Abstract: The present invention provide methods for utilizing spent leukodepletion filter devices as a source of material for the isolation and analysis of genomic DNA (gDNA), including polymorphism, genotyping, and pharmacogenomic studies. Cellular retentate with the filter contains leukocytes, which are lysed to release the nuclei. The nuclei are lysed or ruptured to release genomic DNA, which is then isolated and used for subsequent analysis.Type: ApplicationFiled: August 15, 2001Publication date: July 11, 2002Inventors: Martin A. Smith, Galina N. Fomovskaia, Mikhail A. Fomovsky, Neil J. Butt, Matthew Baker
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Publication number: 20020081618Abstract: The invention relates to methods, a kit, and an apparatus for detecting and analyzing genetic material from a biological sample. The method can be used to analyze samples from a wide variety of sources, including tissues, blood, plasma, sera, mucus, urine, saliva, sweat, semen, and cultures, as well as analyzing samples of contaminated water, food, beverages, and other items.Type: ApplicationFiled: November 14, 2001Publication date: June 27, 2002Inventors: Richard Philpott, Martin A. Smith, Frank D. Igoe, James C. Davis
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Publication number: 20020054833Abstract: According to the present invention, there is provided a multiwell device including a multiwell plate having at least one well, wherein each well has an open end portion and a sealing mechanism disposed over each well. The sealing mechanism prevents the loss of contents from each well after the sealing mechanism receives and is penetrated by a material transfer device during a material transfer procedure. Additionally, the present invention provides for a sealing mechanism for being disposed over a plurality of wells of a multiwell plate. The sealing mechanism prevents loss of content from the wells during a material transfer procedure. The present invention also provides for a method of transferring material from the wells of the multiwell device including the steps of puncturing the sealing matrix with the material transfer device and preventing cross-contamination of the content with other wells.Type: ApplicationFiled: May 26, 2001Publication date: May 9, 2002Inventors: Daqing Qu, Martin A. Smith, Andrew M. Mitchell, Neil James Butt, James C. Davis, Steven J. Kabachus
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Publication number: 20010007746Abstract: A medium for storage and subsequent analysis of a genetic material includes a support for immobilizing the genetic material thereon and allowing subsequent elution of the genetic material therefrom and a coating functionally associated with the support for enabling cellular lysis and releasing the genetic material from the lysed cells while stabilizing the immobilized released genetic material.Type: ApplicationFiled: September 18, 1999Publication date: July 12, 2001Inventors: MARTIN A. SMITH, MRIDULA IYER, DAQING QU, JAMES C. DAVIS
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Publication number: 20010000149Abstract: A medium for storage and subsequent analysis of a genetic material includes a support for immobilizing the genetic material thereon and allowing subsequent elution of the genetic material therefrom and a coating functionally associated with the support for enabling cellular lysis and releasing the genetic material from the lysed cells while stabilizing the immobilized released genetic material.Type: ApplicationFiled: November 30, 2000Publication date: April 5, 2001Inventors: Martin A. Smith, Mridula Iyer, Daqing Qu, James C. Davis
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Patent number: 5674029Abstract: A weir structure for controlling liquid flow in a channel having a floor and side walls comprising a barrier extending between the sidewalls of the channel and from the floor of the channel to a crest to separate the channel into an upstream region and a downstream region. Fluid in the channel flows from the upstream region to the downstream region by overflowing the barrier at the crest. The barrier is formed with at least one passage through the barrier positioned and dimensioned to allow for free, unregulated fluid flow through the passage from the upstream region to the downstream region whenever fluid is overflowing the barrier to increase flow past the barrier.Type: GrantFiled: December 28, 1994Date of Patent: October 7, 1997Assignee: UV Waterguard Systems, Inc.Inventors: Martin A. Smith, Douglas F. Sommerville, Peter W. Emmett, John R. Gaetz
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Patent number: 4802788Abstract: A road marking apparatus has a hopper mounted upon a pair of side runners that straddle an outlet in the bottom of the hopper. A doctor blade is mounted for reciprocal vertical movement in sliding contact with the outside of a rear wall of the hopper adjacent the hopper outlet between the runners. A floor gate is mounted for reciprocal horizontal movement into and out of contact with a bottom edge of the hopper rear wall and the doctor blade for opening and closing the hopper outlet.Type: GrantFiled: January 13, 1988Date of Patent: February 7, 1989Assignee: Pave-Mark CorporationInventor: Martin A. Smith
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Patent number: 4623279Abstract: A preheater for melting a slab of thermoplastic marking material preparatory to applying a melt therefrom onto a paved surface has a heated slab receiver formed with a side wall oriented between 70.degree. and 82.degree. with respect to a reference ground plane upon which surface a slab may be flushly supported for heating and melt down.Type: GrantFiled: July 16, 1984Date of Patent: November 18, 1986Assignee: Pave-Mark CorporationInventor: Martin A. Smith
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Patent number: 4101058Abstract: An apparatus for applying glass spheres or other dry particles at prescribed adjustable widths without wastage of material by gravity feeding such spheres upon a roller assembly comprising a plurality of roller sections selectively engagable for rotation by a continuously driven coaxial drive shaft.Type: GrantFiled: April 14, 1977Date of Patent: July 18, 1978Inventor: Martin A. Smith