Abstract: Embodiments of the present techniques provide apparatus and methods for analysing intracoronary images, for example to predict the likelihood of a disease, disease presentation or event, and/or to track performance of a drug or other treatment. The method may comprise: for each image in the set of images of a coronary artery: classifying the image, using a first neural network, for the presence or absence of diseased tissue; when the image is classified as having diseased tissue present, classifying the image, using a second neural network, for the presence or absence of an artefact; determining whether to analyse the image based on the classifying steps; when the image is to be analysed, analysing the image by identifying, using a third neural network, one or more features of interest in a coronary artery tissue; and measuring each identified feature of interest.

Abstract: The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, where R1, A1, A2 and A3 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent DNA-PK mediated disease, including cancer. The specification further relates to pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating DNA-PK mediated disease, including cancer, using such compounds and salts.

Abstract: A guidance system for a missile performs a method for guiding the missile. The guidance system includes a target detector and a window between a target and the target detector. The window including a first pane, a second pane and a channel between the first pane from the second pane. Radiation from the target passes through the window including the first pane, the second pane and the channel to be detected at the target detector. A gas is transported through the channel between the first pane and the second pane to control a temperature of the window.

Abstract: A guidance system for a missile performs a method for guiding the missile. The guidance system includes a target detector and a window between a target and the target detector. The window including a first pane, a second pane and a channel between the first pane from the second pane. Radiation from the target passes through the window including the first pane, the second pane and the channel to be detected at the target detector. A gas is transported through the channel between the first pane and the second pane to control a temperature of the window.