Patents by Inventor Martin Adelson
Martin Adelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10041130Abstract: Disclosed are diagnostic methods for determining a subtype of methicillin-resistant Staphylococcus aureus (MRSA) in a biological sample of a mammal. Methods include providing a biological sample of the mammal, performing a PCR analysis of the biological sample, and analyzing the PCR amplicons with respect to their sizes so as to determine for type I, type II, type III, type IV or type V MRSA that may be present in the biological sample. Further example embodiments include using at least one mecA primer pair and/or using at least one Staphylococcus aureus nuc primer pair in the PCR analysis. Further disclosed are methods for screening populations for MRSA, and methods of treating a mammal testing positive for Type IV MRSA. Also disclosed are kits for determining a MRSA subtype in a mammal and isolated primers that may be used in the present methods and kits.Type: GrantFiled: March 18, 2014Date of Patent: August 7, 2018Assignee: Medical Diagnostic Laboratories, LLCInventors: Scott Elliot Gygax, Christina Lim Overmyer, Lisa A. DeSalvia, Martin Adelson, Eli Mordechai
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Publication number: 20170372041Abstract: A method and kit related thereto are described for the collection and maintenance of detectability of a plurality of species of microbiological agents in a single clinical sample as well as an integral method for handling a plurality of the samples and managing information associated therewith for reporting a sum of diagnostic results for each sample.Type: ApplicationFiled: August 18, 2017Publication date: December 28, 2017Inventors: MARTIN ADELSON, ELI MORDECHAI
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Publication number: 20170098061Abstract: A method is provided for receiving and handling a plurality of clinical samples and managing information associated therewith for generating and reporting any of a plurality of different diagnostic results from each sample in a timely manner, particularly within about thirty (30) hours. Methods described comprise, for example, receiving a plurality of single gynecological swab samples, each having identity and test requisition information associated therewith, wherein the test requisition information indicates a test for at least one causative agent, from a choice of a plurality of agents (for example, between about 5 and about 25 different microbiological agents) and managing information associated therewith for generating and reporting any of a plurality of different diagnostic results for each sample.Type: ApplicationFiled: December 15, 2016Publication date: April 6, 2017Applicant: Medical Diagnostic Laboratories, LLCInventors: Martin Adelson, Eli Mordechai
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Publication number: 20140303072Abstract: Disclosed are diagnostic methods for determining a subtype of methicillin-resistant Staphylococcus aureus (MRSA) in a biological sample of a mammal. Methods include providing a biological sample of the mammal, performing a PCR analysis of the biological sample, and analyzing the PCR amplicons with respect to their sizes so as to determine for type I, type II, type III, type IV or type V MRSA that may be present in the biological sample. Further example embodiments include using at least one mecA primer pair and/or using at least one Staphylococcus aureus nuc primer pair in the PCR analysis. Further disclosed are methods for screening populations for MRSA, and methods of treating a mammal testing positive for Type IV MRSA. Also disclosed are kits for determining a MRSA subtype in a mammal and isolated primers that may be used in the present methods and kits.Type: ApplicationFiled: March 18, 2014Publication date: October 9, 2014Applicant: MEDICAL DIAGNOSTIC LABORATORIES, LLCInventors: Scott Elliot Gygax, Christina Lim Overmyer, Lisa A. DeSalvia, Martin Adelson, Eli Mordechai
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Patent number: 8377656Abstract: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Cryptococcus neoformans, a causative agent for human cryptococcosis. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the fungal specific transcription factor gene in Cryptococcus neoformans, are useful as forward and reverse primers for a polymerase chain reaction using nucleic acids from a biological sample as templates, and as probes for detecting any resultant amplicon. Detection of an amplicon indicates the sample contains Cryptococcus neoformans. Real-time PCR and detection using florescence resonance energy transfer is disclosed.Type: GrantFiled: June 23, 2011Date of Patent: February 19, 2013Assignee: Medical Diagnostic Laboratories, LLCInventors: Melanie Feola, John Entwistle, Martin Adelson, Eli Mordechai
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Patent number: 8206930Abstract: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Borrelia afzelii, a spirochete which is a causative agent of Lyme disease in humans. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the p24 gene for the outer surface protein of Borrelia afzelii, are useful as forward and reverse primers for a polymerase chain reaction using nucleic acids from a biological sample as templates, and as probes for detecting any resultant amplicon. Detection of an amplicon indicates the sample contains Borrelia afzelii. Real-time PCR and detection using florescence resonance energy transfer is disclosed.Type: GrantFiled: August 18, 2011Date of Patent: June 26, 2012Assignee: Medical Diagnostics Laboratories, LLCInventors: Melanie Feola, Martin Adelson, Eli Mordechai, Lisa Novak
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Publication number: 20120122092Abstract: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Borrelia afzelii, a spirochete which is a causative agent of Lyme disease in humans. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the p24 gene for the outer surface protein of Borrelia afzelii, are useful as forward and reverse primers for a polymerase chain reaction using nucleic acids from a biological sample as templates, and as probes for detecting any resultant amplicon. Detection of an amplicon indicates the sample contains Borrelia afzelii. Real-time PCR and detection using florescence resonance energy transfer is disclosed.Type: ApplicationFiled: August 18, 2011Publication date: May 17, 2012Applicant: Medical Diagnostic Laboratories, LLCInventors: Melanie Feola, Martin Adelson, Eli Mordechai, Lisa Novak
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Publication number: 20120015362Abstract: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Cryptococcus neoformans, a causative agent for human cryptococcosis. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the fungal specific transcription factor gene in Cryptococcus neoformans, are useful as forward and reverse primers for a polymerase chain reaction using nucleic acids from a biological sample as templates, and as probes for detecting any resultant amplicon. Detection of an amplicon indicates the sample contains Cryptococcus neoformans. Real-time PCR and detection using florescence resonance energy transfer is disclosed.Type: ApplicationFiled: June 23, 2011Publication date: January 19, 2012Applicant: Medical Diagnostic Laboratories LLCInventors: Melanie Feola, Martin Adelson, Eli Mordechai, John Entwistle
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Patent number: 8026056Abstract: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Borrelia afzelii, a spirochete which is a causative agent of Lyme disease in humans. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the p24 gene for the outer surface protein of Borrelia afzelii, are useful as forward and reverse primers for a polymerase chain reaction using nucleic acids from a biological sample as templates, and as probes for detecting any resultant amplicon. Detection of an amplicon indicates the sample contains Borrelia afzelii. Real-time PCR and detection using florescence resonance energy transfer is disclosed.Type: GrantFiled: May 29, 2008Date of Patent: September 27, 2011Assignee: Medical Diagnostic Laboratories, LLCInventors: Melanie Feola, Martin Adelson, Eli Mordechai, Lisa Novak
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Patent number: 7989186Abstract: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Cryptococcus neoformans, a causative agent for human cryptococcosis. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the fungal specific transcription factor gene in Cryptococcus neoformans, are useful as forward and reverse primers for a polymerase chain reaction using nucleic acids from a biological sample as templates, and as probes for detecting any resultant amplicon. Detection of an amplicon indicates the sample contains Cryptococcus neoformans. Real-time PCR and detection using florescence resonance energy transfer is disclosed.Type: GrantFiled: June 18, 2008Date of Patent: August 2, 2011Assignee: Medical Diagnostic Laboratories, LLCInventors: Melanie Feola, Martin Adelson, Eli Mordechai, John Entwistle
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Publication number: 20090275023Abstract: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Borrelia afzelii, a spirochete which is a causative agent of Lyme disease in humans. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the p24 gene for the outer surface protein of Borrelia afzelii, are useful as forward and reverse primers for a polymerase chain reaction using nucleic acids from a biological sample as templates, and as probes for detecting any resultant amplicon. Detection of an amplicon indicates the sample contains Borrelia afzelii. Real-time PCR and detection using florescence resonance energy transfer is disclosed.Type: ApplicationFiled: May 29, 2008Publication date: November 5, 2009Applicant: Medical Diagnostic Lab. LLCInventors: Melanie Feola, Martin Adelson, Eli Mordechai, Lisa Novak
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Publication number: 20090246767Abstract: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Cryptococcus neoformans, a causative agent for human cryptococcosis. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the fungal specific transcription factor gene in Cryptococcus neoformans, are useful as forward and reverse primers for a polymerase chain reaction using nucleic acids from a biological sample as templates, and as probes for detecting any resultant amplicon. Detection of an amplicon indicates the sample contains Cryptococcus neoformans. Real-time PCR and detection using florescence resonance energy transfer is disclosed.Type: ApplicationFiled: June 18, 2008Publication date: October 1, 2009Applicant: MEDICAL DIAGNOSTIC LABORATORIES, LLCInventors: Melanie Feola, Martin Adelson, Eli Mordechai, John Entwistle
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Publication number: 20070122857Abstract: Disclosed are antibodies that bind to the antigenic proteins GroES, RplL, GroEL, SodB, UbiG, the ABC transporter, and an expressed antigenic protein of unknown function (the “BepA” protein) of Bartonella henselae, and use of these antigenic proteins in immunoassays in order to determine whether a sample from a subject contains one or more of these antibodies. Presence of such an antibody in the subject indicates that the subject is or was infected with Bartonella henselae, or indicates that the subject has an increased likelihood of being infected presently or in the past with Bartonella henselae. Also disclosed are kits for performing immunoassays, wherein each kit contains one or more of these antigenic proteins and also contains the reagents necessary for conducting an immunoassay.Type: ApplicationFiled: May 3, 2006Publication date: May 31, 2007Inventors: Tera McCool, Chien Loa, Eli Mordechai, Martin Adelson
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Publication number: 20070042355Abstract: A method and kit related thereto are described for the collection and maintenance of detectability of a plurality of species of microbiological agents in a single clinical sample as well as an integral method for handling a plurality of the samples and managing information associated therewith for reporting a sum of diagnostic results for each sample.Type: ApplicationFiled: January 31, 2006Publication date: February 22, 2007Inventors: Martin Adelson, Eli Mordechai
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Publication number: 20060246423Abstract: A method and kit related thereto are described for the collection and maintenance of detectability of a plurality of species of microbiological agents selected from the group consisting of bacteria, fungi, viruses, and protozoa, in a single gynecological sample which comprises providing transport media in a resealable container and instructions for preparation and handling of the gynecological sample and a written indication of the detectability of a plurality of species.Type: ApplicationFiled: January 31, 2006Publication date: November 2, 2006Inventors: Martin Adelson, Eli Mordechai
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Publication number: 20060178838Abstract: A method is provided for receiving and handling a plurality of clinical samples and managing information associated therewith for generating and reporting any of a plurality of different diagnostic results from each sample in a timely manner, particularly within about thirty (30) hours. Methods described comprise, for example, receiving a plurality of single gynecological swab samples, each having identity and test requisition information associated therewith, wherein the test requisition information indicates a test for at least one causative agent, from a choice of a plurality of agents (for example, between about 5 and about 25 different microbiological agents) and managing information associated therewith for generating and reporting any of a plurality of different diagnostic results for each sample.Type: ApplicationFiled: January 31, 2006Publication date: August 10, 2006Inventors: Martin Adelson, Eli Mordechai
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Publication number: 20060127934Abstract: Oligonucleotides and methods for using these oligonucleotides in the detection of Aspergillus fumigatus are disclosed. Aspergillus fumigatus is the causative agent for medical conditions including invasive aspergillosis. The oligonucleotides of the invention have nucleotide sequences derived from the gene encoding the cytochrome P450 14 alpha-sterol demethylase (i.e., the Cyp51A protein) of Aspergillus fumigatus. The oligonucleotides of the invention include forward primers and reverse primers which in combination are capable of priming the synthesis of amplicons specific to cyp51A in polymerase chain reactions using nucleic acids isolated from Aspergillus fumigatus as templates. The oligonucleotides of the invention also include probes capable of detecting these cyp51A-specific amplicons.Type: ApplicationFiled: December 9, 2005Publication date: June 15, 2006Inventors: Jason Trama, Martin Adelson, Eli Mordechai
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Publication number: 20060088865Abstract: Methods are described herein for detecting and identifying distinct species of nucleic acids, in a single container, for example, from a certain genus of infectious agents or otherwise causative agents comprising, for example, providing a forward PCR primer common to a homologous gene region between the distinct species, and providing a reverse PCR primer common to a homologous gene region between the distinct species, to thereby define a PCR target region amongst the species, and providing a first oligonucleotide probe specific to a nucleic acid sequence within the target region that is characteristic of a first species, providing a second oligonucleotide probe specific to a nucleic acid sequence within the target region that is characteristic of a second species, wherein the first and second oligonucleotide probes are each detectably labeled with distinctly different detectable labels, conducting a PCR reaction in the container by means of the primers to amplify the target region amongst the species, and deType: ApplicationFiled: October 7, 2005Publication date: April 27, 2006Inventors: Martin Adelson, Melanie Feola, Jason Trama, Eli Mordechai