Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I) is useful as an agent for the prophylaxis or treatment of narcolepsy.

Abstract: The invention relates to a polypropylene composition comprising a terpolymer composition comprising (A) a first terpolymer fraction containing propylene, ethylene and 1-hexene, wherein the first terpolymer fraction has a melt flow rate of 0.005 to 0.20 dg/min determined by ISO 1133-1:2011 (230° C., 2.16 kg) and (B) a second terpolymer fraction containing propylene, ethylene and 1-hexene, wherein the second terpolymer fraction has a melt flow rate of 0.30 to 70 dg/min determined by ISO 1133-1:2011 (230° C., 2.16 kg), wherein the first terpolymer fraction is prepared using a first set of reaction conditions, the second terpolymer fraction is prepared using a second set of reaction conditions and the first and second set of reaction conditions are different, wherein the polypropylene composition (i) has a melt flow rate of 0.10 to 0.70 dg/min determined by ISO 1133-1-2011 (230° C., 2.16 kg), (ii) has a content of ethylene derived units in the range from 1.6 to 3.

Abstract: A method, apparatus, system, and computer program product for processing a composite ply. An image of the composite ply is received. Natural features in the image of the composite ply are detected. Feature data for the natural features detected in association is saved with a ply identifier for the composite ply in a repository. The feature data is used to position the composite ply during manufacturing of a composite part using the composite ply.

Abstract: A chat communication session is established between a first and second network device. Displayable content is generated during the chat communication session for transmission by the first network device, where the displayable content includes (i) a first chat question, (ii) a first set of interactive responses to the first chat question, and (iii) a first text field. The displayable content is transmitting by the first network device to the second network device. In response to selection of one of the first set of interactive responses at the second network device, at least a second chat question is generated along with a second set of interactive responses to the second chat question is generated for transmission. However, responsive to detecting text entry within the first text field, the first network device is configured to provide an operator with access to the chat communication session for response to the text entry.

Abstract: The invention relates to a polypropylene composition comprising a terpolymer composition comprising (A) a first terpolymer fraction containing propylene, ethylene and 1-hexene, wherein the first terpolymer fraction has a melt flow rate of 0.005 to 0.20 dg/min determined by ISO 1133-1:2011 (230° C., 2.16 kg) and (B) a second terpolymer fraction containing propylene, ethylene and 1-hexene, wherein the second terpolymer fraction has a melt flow rate of 0.30 to 70 dg/min determined by ISO 1133-1:2011 (230° C., 2.16 kg), wherein the first terpolymer fraction is prepared using a first set of reaction conditions, the second terpolymer fraction is prepared using a second set of reaction conditions and the first and second set of reaction conditions are different, wherein the polypropylene composition (i) has a melt flow rate of 0.10 to 0.70 dg/min determined by ISO 1133-1:2011 (230° C., 2.16 kg), (ii) has a content of ethylene derived units in the range from 1.6 to 3.

Abstract: A series of 2-imino-6-methylhexahydropyrimidin-4-one derivatives, substituted in the 6-position by an arylphenyl or heteroarylphenyl moiety, being potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood, are beneficial as pharmaceutical agents, especially in the treatment of malaria.

Abstract: A manufacturing system includes a stator base, a plurality of movers, one or more end effectors, and a controller. The stator base has a planar stator surface covering an array of electrical coils configured to generate an electromagnetic field. The movers each contain multiple permanent magnets configured to cause the movers to levitate and move relative to the stator surface in response to the electromagnetic field. The end effectors are coupled to the movers, and each end effector perform one or more functions in relation to a material sheet. The controller activates the electrical coils in a manner causing independent, coordinated movement of the movers over the stator surface, and causing the end effectors to engage with and operate on the material sheet.

Abstract: The compounds of formula (I) as defined herein, being potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood, are beneficial as pharmaceutical agents, especially in the treatment of malaria.

Abstract: The invention relates to a system for ergonomic training, comprising a server, a plurality of stations, each of the stations including at least one predefined object to be handled by a test person, wherein a predefined manner of handling the predefined object is defined for each predefined object, and each station comprising a localization arrangement. The system furthermore comprises a mobile kit to be carried by a test person, including at least three wearable inertial sensors to be worn by the test person and configured for recording and storing sensor data indicative of a movement of the test person, wherein the mobile kit further includes a localization device configured for interaction with the localization arrangement of each station. The system is configured to determine that the localization device is in proximity of the localization arrangement of a specific station, based on an interaction between the localization device and the localization arrangement of the specific station.

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

Abstract: A method, apparatus, and system for manufacturing a composite part. A set of reference locations is identified for a set of fiducial markers on a composite ply from a ply shape model for the composite part. The set of fiducial markers is created at the set of reference locations on the composite ply. The composite ply is cut to have a shape defined by the ply shape model.

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.

Abstract: A process for the production of a propylene homopolymer or a propylene-ethylene copolymer includes polymerizing propylene and optional ethylene comonomers in the presence of a catalyst, wherein the catalyst is obtainable by a process of A) providing a Ziegler-Natta procatalyst including contacting a magnesium-containing support with i) a halogen-containing titanium compound, ii) ethylbenzoate as an activator, iii) and as internal donor an aminobenzoate compound according to formula B preferably 4-[benzoyl(methyl)amino]pentan-2-yl benzoate (AB); and B) contacting the Ziegler-Natta procatalyst obtained in step A) with a co-catalyst and a Selectivity Control Agent (SCA) in combination with an Activity Limiting Agent (ALA) to obtain the catalyst.

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.

Abstract: A manufacturing system includes a stator base, a plurality of movers, one or more end effectors, and a controller. The stator base has a planar stator surface covering an array of electrical coils configured to generate an electromagnetic field. The movers each contain multiple permanent magnets configured to cause the movers to levitate and move relative to the stator surface in response to the electromagnetic field. The end effectors are coupled to the movers, and each end effector perform one or more functions in relation to a material sheet. The controller activates the electrical coils in a manner causing independent, coordinated movement of the movers over the stator surface, and causing the end effectors to engage with and operate on the material sheet.

Abstract: A process for preparing a procatalyst for polymerization of olefins, comprising contacting a magnesium-containing support with a halogen-containing titanium compound, and an internal electron donor according to Formula (I), said process comprising the steps of: i) contacting a compound R4zMgX42-z with an alkoxy- or aryloxy-containing silane compound to give a first intermediate reaction product, being a solid Mg(OR1)xX12-x, ii) optionally contacting the solid Mg(OR1)xX12-x obtained in step ii) with at least one activating compound selected from the group formed by activating electron donors and metal alkoxide compounds of formula M1(OR2)v-w(OR3)w or M2(OR2)v-w(R3)w, to obtain a second intermediate product; iii) contacting the first or second intermediate reaction product, obtained respectively in step i) or ii), with a halogen-containing Ti-compound and said compound represented Formula (I), as the internal electron donor.

Abstract: A method, apparatus, system, and computer program product for processing a composite ply. An image of the composite ply is received. Natural features in the image of the composite ply are detected. Feature data for the natural features detected in association is saved with a ply identifier for the composite ply in a repository. The feature data is used to position the composite ply during manufacturing of a composite part using the composite ply.

Abstract: The invention relates to a polypropylene composition comprising a terpolymer containing propylene, ethylene and 1-hexene wherein the polypropylene composition (i) has a content of ethylene derived units of at least 1.5 wt %; (ii) has a content of 1-hexene derived units of at least 1.5 wt %; (iii) has a melt flow rate of 0.10 to 0.70 g/10 min determined by ISO 1133-1:2011 (230° C., 2.16 kg); and (iv) has a ratio of weight average molecular weight (Mw) to numeric average molecular (Mn) weight of the terpolymer of 7.0 to 20.0, wherein Mw and Mn are measured according to ASTM D6474-12.

Abstract: A method, apparatus, and system for manufacturing a composite part. A set of reference locations is identified for a set of fiducial markers on a composite ply from a ply shape model for the composite part. The set of fiducial markers is created at the set of reference locations on the composite ply. The composite ply is cut to have a shape defined by the ply shape model.