Abstract: Provided herein are anti-CCR8 antibodies or antigen binding fragment thereof, which bind to CCR8, wherein the CCR8 is a human CCR8 and the antibody does not bind human CCR4. The anti-CCR8 antibodies or antigen binding fragment of the disclosure are useful for the treatment of cancer diseases through the elimination of regulatory T cells. Also provided herein are methods of use for the anti-CCR8 antibodies or antigen binding fragment thereof.

Abstract: A storage device write-read error reduction system includes a computing device that includes a storage device. The storage device determines, at a temperature that is within a predefined temperature range, that a storage device background operation should be performed and, in response, identifies data that is stored in the storage device and that was written to the storage device outside the predefined temperature range. The storage device then prioritizes the data that was written to the storage device outside the predefined temperature range over data that was written to the storage device within the predefined temperature range and, based on that prioritization, performs the storage device background operation to rewrite the data to the storage device.

Abstract: A hardware-type-based multi-component personality configuration system includes a first component stock including first hardware type components having a first hardware type, a second component stock including second hardware type components having a second hardware type that is different than the first hardware type, and a component configuration system. The component configuration system identifies computing device order(s) for computing device(s) that include a plurality of components, and determines that a respective personality configuration in the computing device order(s) for each of a first subset of the plurality components included in the computing device(s) may be provided by the first hardware type components.

Abstract: The disclosed calibration method includes a calibration phantom positioned on an adjustable table on the surface of a mechanical couch, with the phantom's centre at an estimated location for the iso-centre of a radio therapy treatment apparatus. The calibration phantom is then irradiated using the apparatus, and the relative location of the center of the calibration phantom and the iso-centre of the apparatus is determined by analyzing images of the irradiation of the calibration phantom. The calibration phantom is then repositioned by the mechanical couch applying an offset corresponding to the determined relative location of the centre of the calibration phantom and the iso-centre of the apparatus to the calibration phantom. Images of the relocated calibration phantom are obtained, to which the offset has been applied, and the obtained images are processed to set the co-ordinate system of a stereoscopic camera system relative to the iso-centre of the apparatus.

Abstract: A secure one-time programming undo system includes a component and a component configuration system. A one-time programming subsystem in the component configuration system provides the component with personality configuration information that configures the component to perform component operations, and performs a one-time programming operation that configures a component engine in the component to deny modification requests to modify the personality configuration information.

Abstract: A storage device projected temperature environment configuration system includes storage devices with the same physical hardware configuration, and a computing device manufacturing system that manufactures computing devices.

Abstract: A storage device projected temperature environment configuration system includes storage devices with the same physical hardware configuration, and a computing device manufacturing system that manufactures computing devices.

Abstract: The disclosed calibration method includes a calibration phantom positioned on an adjustable table on the surface of a mechanical couch, with the phantom's centre at an estimated location for the iso-centre of a radio therapy treatment apparatus. The calibration phantom is then irradiated using the apparatus, and the relative location of the center of the calibration phantom and the iso-centre of the apparatus is determined by analyzing images of the irradiation of the calibration phantom. The calibration phantom is then repositioned by the mechanical couch applying an offset corresponding to the determined relative location of the centre of the calibration phantom and the iso-centre of the apparatus to the calibration phantom. Images of the relocated calibration phantom are obtained, to which the offset has been applied, and the obtained images are processed to set the co-ordinate system of a stereoscopic camera system relative to the iso-centre of the apparatus.

Abstract: A retaining ring can be shaped by machining or lapping the bottom surface of the ring to form a shaped profile in the bottom surface. The bottom surface of the retaining ring can include flat, sloped and curved portions. The lapping can be performed using a machine that dedicated for use in lapping the bottom surface of retaining rings. During the lapping the ring can be permitted to rotate freely about an axis of the ring. The bottom surface of the retaining ring can have curved or flat portions.

Abstract: An example material testing system includes: an actuator configured to control an operator-accessible component of the material testing system; and one or more processors configured to: control the actuator based on a material testing process; determine, based on a plurality of inputs, a state of the material testing system from a plurality of predetermined states, the predetermined states comprising one or more unrestricted states and one or more restricted states; when the state of the material testing system is one of the restricted states, enforce a restriction on the actuator; and in response to completion of an automated material test process involving controlling the actuator, automatically set the state of the material testing system to one of the restricted states.

Abstract: The disclosed calibration method includes a calibration phantom positioned on an adjustable table on the surface of a mechanical couch, with the phantom's centre at an estimated location for the iso-centre of a radio therapy treatment apparatus. The calibration phantom is then irradiated using the apparatus, and the relative location of the center of the calibration phantom and the iso-centre of the apparatus is determined by analyzing images of the irradiation of the calibration phantom. The calibration phantom is then repositioned by the mechanical couch applying an offset corresponding to the determined relative location of the centre of the calibration phantom and the iso-centre of the apparatus to the calibration phantom. Images of the relocated calibration phantom are obtained, to which the offset has been applied, and the obtained images are processed to set the co-ordinate system of a stereoscopic camera system relative to the iso-centre of the apparatus.

Abstract: Images obtained by a camera system (10) arranged to obtain images of a patient (20) undergoing radio-therapy are processed by a modeling unit (56,58) which generates a model of the surface of a patient (20) being monitored. Additionally the patient monitoring system processes image data not utilized to generate a model of the surface of a patient being monitored to determine further information concerning the treatment of the patient(20). Such additional data can comprise data identifying the relative location of the patient and a treatment apparatus (16). This can be facilitated by providing a number or retro-reflective markers (30-40) on a treatment apparatus (16) and a mechanical couch (18) used to position the patient (20) relative to the treatment apparatus (16) and monitoring the presence and location of the markers in the portions of the images obtained by the stereoscopic camera (10).

Abstract: An example material testing system includes: an actuator configured to control an operator-accessible component of the material testing system; and one or more processors configured to: control the actuator based on at least one of an operator command or a material testing process; determine, based on a plurality of inputs, a state of the material testing system from a plurality of predetermined states, the predetermined states comprising one or more unrestricted states and one or more restricted states; when the state of the material testing system is one of the restricted states, enforce a restriction on the actuator; and in response to completion of an action involving controlling the actuator, automatically set the state of the material testing system to one of the restricted states.

Abstract: Disclosed example video extensometers include: a load string configured to secure a test specimen; an imaging device configured to capture images of a surface of the test specimen when secured in the load string; a storage device configured to store a plurality of first calibration parameters corresponding to intrinsic properties of the imaging device; and control circuitry configured to: perform a verification process using the first calibration parameters to verify that a plurality of second calibration parameters correspond to an arrangement of the test specimen with respect to the imaging device; and perform an optical strain measurement process to measure displacement of the test specimen based on the first calibration parameters and the second calibration parameters.

Abstract: A retaining ring can be shaped by machining or lapping the bottom surface of the ring to form a shaped profile in the bottom surface. The bottom surface of the retaining ring can include flat, sloped and curved portions. The lapping can be performed using a machine that dedicated for use in lapping the bottom surface of retaining rings. During the lapping the ring can be permitted to rotate freely about an axis of the ring. The bottom surface of the retaining ring can have curved or flat portions.

Abstract: Safety systems and material testing systems including safety systems are disclosed. An example material testing system includes: at least one actuator configured to control one or more operator-accessible components of the material testing system; an actuator disabling circuit configured to disable the at least one actuator; and one or more processors configured to: control the at least one actuator based on a material testing process; monitor a plurality of inputs associated with operation of the material testing system; determine, based on the plurality of inputs and the material testing process, a state of the material testing system from a plurality of predetermined states, the predetermined states comprising one or more unrestricted states and one or more restricted states; and control the actuator disabling circuit based on the determined state.

Abstract: The disclosed calibration method includes a calibration phantom positioned on an adjustable table on the surface of a mechanical couch, with the phantom's centre at an estimated location for the iso-centre of a radio therapy treatment apparatus. The calibration phantom is then irradiated using the apparatus, and the relative location of the center of the calibration phantom and the iso-centre of the apparatus is determined by analyzing images of the irradiation of the calibration phantom. The calibration phantom is then repositioned by the mechanical couch applying an offset corresponding to the determined relative location of the centre of the calibration phantom and the iso-centre of the apparatus to the calibration phantom. Images of the relocated calibration phantom are obtained, to which the offset has been applied, and the obtained images are processed to set the co-ordinate system of a stereoscopic camera system relative to the iso-centre of the apparatus.

Abstract: Images obtained by a camera system (10) arranged to obtain images of a patient (20) undergoing radio-therapy are processed by a modeling unit (56,58) which generates a model of the surface of a patient (20) being monitored. Additionally the patient monitoring system processes image data not utilized to generate a model of the surface of a patient being monitored to determine further information concerning the treatment of the patient (20). Such additional data can comprise data identifying the relative location of the patient and a treatment apparatus (16). This can be facilitated by providing a number or retro-reflective markers (30-40) on a treatment apparatus (16) and a mechanical couch (18) used to position the patient (20) relative to the treatment apparatus (16) and monitoring the presence and location of the markers in the portions of the images obtained by the stereoscopic camera (10).

Abstract: A tensioner for adjusting a tension in an endless track of a track system is disclosed. The tensioner includes a resilient portion and a wheel connecting portion. The resilient portion is connectable to a frame of the track system, the resilient portion being oriented generally vertically. The wheel connecting portion is pivotally connectable to the frame of the track system, is connected to the resilient portion and is configured to connect to an idler wheel assembly. A track system having the tensioner is also disclosed.

Abstract: A modular frame for a track system is disclosed. The modular frame includes an upper frame member operatively connectable to an axle of a vehicle and removably connectable to a first lower frame member. The first lower frame member is configured to connect with at least one of a support wheel assembly and an idler wheel assembly, and connection of the upper frame member to the first lower frame member confers a first lower frame member-specific function to the track system. Another modular frame, track systems having the modular frames, tensioners and track systems having the tensioners are also disclosed.