Abstract: The invention provides novel 6-heterocyclyl-4-morpholin-4-yl-pyridine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and A are as defined in the specification.

Abstract: The invention provides novel 6-aryl or 6-heteroaryl 4-morpholin-4-yl-pyhdine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory diseases, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, a R3 and R4 are as defined in the specification.

Abstract: An antimicrobial amphiphilic hydrogel composition for use in haemostasis of a wound comprising: a first cross-linkable amphiphilic component, the first amphiphilic component, in its chemically cross-linked state, being a lyotropic liquid crystal and having an ordered nanostructure of hydrophobic and hydrophilic domains, the hydrogel comprising an antimicrobial agent covalently attached to the hydrophilic and/or hydrophobic domains.

Abstract: A system and a method include one or more control units including one or more processors. The control unit(s) is configured to automatically assign crew members to trips of one or more vehicles to form one or more rosters for the crew members. The control unit(s) is further configured to automatically reconfigure one or more of the trips in response to determining one or more conflicts between the one or more of the trips and availability of the crew members for the one or more of the trips. The control unit(s) is configured to automatically reconfigure the one or more trips by reconfiguring the one or more trips into a plurality of sub-trips.

Abstract: The present invention relates to a method for determining the three dimensional structure of biomolecules, such as proteins, protein fragments, and peptides. The biomolecule is encapsulated in an amorphous silica matrix, from which a needle specimen is prepared. Atom probe tomography is then used to analyze the needle specimen and the data is used to reconstruct the three dimensional structure of the biomolecule. The present invention greatly facilitates determination of the three dimensional structure of biomolecules.

Abstract: A method comprising an arc ignition phase (IP), an arc-stabilizing phase (AP) and a stable arc phase (SP). The arc stabilizing phase comprises an initial sub-phase (IS) comprising the step of feeding at least one hot wire (4, 12) at constant feed speed and a main sub-phase (MS) comprising the steps of feeding said hot wire at constant feed speed and feeding at least one cold wire (22) at constant feed speed. The stable arc phase comprises the steps of continuously adjusting the feed speed of the hot wire and continuously adjusting the feed speed of the cold wire. The invention also relates to a welding apparatus (1) for carrying out the method. The welding apparatus comprises a hot wire feeding means (150), a contact means (2), a cold wire feeding means (35) and a control unit (31).

Abstract: The invention provides novel 6-aryl or 6-heteroaryl 4-morpholin-4-yl-pyhdine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory diseases, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and R4 are as defined in the specification.

Abstract: Resource teaming optimization for resource planning is provided by identifying a set of tasks, wherein each task of the set of tasks includes a plurality of subtasks that includes an initial subtask starting at a given state and a final subtask returning to the given state; identifying resource requirements for each subtasks of the plurality of subtasks; dividing a set of resources into a plurality of candidate slices to meet resource requirements for the plurality of subtasks; forming a plurality of combinations from the plurality of candidate slices to satisfy the resource requirements; identifying a given combination from the plurality of combinations having a highest teaming metric across the set of tasks; and assigning the given combination for the set of tasks.

Abstract: The invention provides novel 6-heterocyclyl-4-morpholin-4-yl-pyridine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and A are as defined in the specification.

Abstract: A macromolecule membrane structure (2) comprises a membrane (3) with water-channeling integral membrane proteins (IMPS) (1) and is coated, on a first surface, with a silica layer (4). The silica layer (4) stabilizes the macromolecule membrane structure (2) and the water-channeling IMPS (1) while maintaining the water-channeling function of the water-channeling IMPs (1). As a consequence of this stabilization, the macromolecule membrane structure (2) may be used in a filtration device (5) for various filtration operations, including water purification.

Abstract: The invention provides novel 6-aryl or 6-heteroaryl 4-morpholin-4-yl-pyhdine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory diseases, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and R4 are as defined in the specification.

Abstract: A solid antimicrobial hydrogel comprising a first amphiphilic component. The first amphiphilic component, in its chemically cross-linked state, being a lyotropic liquid crystal and having an ordered nanostructure of hydrophobic and hydrophilic domains, the composition further comprising an antimicrobial agent being covalently attached to at least one of the hydrophilic or hydrophobic domains.

Abstract: The present invention relates to a method for determining the three dimensional structure of biomolecules, such as proteins, protein fragments and peptides. The biomolecule is encapsulated in an amorphous silica matrix, from which a needle specimen is prepared. Atom probe tomography is then used to analyze the needle specimen and the data is used to reconstruct the three dimensional structure of the biomolecule. The present invention greatly facilitates determination of the three dimensional structure of biomolecules.

Abstract: The invention provides novel 6-heterocyclyl-4-morpholin-4-yl-pyridine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and A are as defined in the specification.

Abstract: A submerged arc welding apparatus includes a first wire feeder feeding a first hot wire towards a work piece; a first contact tube transferring current to the first hot wire for arc generation to create a weld puddle; a second wire feeder feeding a cold wire at a variable feed speed towards the weld puddle; one or more sensors configured to continuously measure, during a welding phase, at least a first active welding parameter related to at least the first hot wire; and a control unit. The control unit is configured to determine different target values for the variable feed speed of the cold wire based on different values of the at least a first active welding parameter such that a different target value for the variable feed speed of the cold wire is determined according to a different value of the at least a first active welding parameter.

Abstract: The invention provides novel 6-aryl or 6-heteroaryl 4-morpholin-4-yl-pyhdine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory diseases, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and R4 are as defined in the specification.

Abstract: The present disclosure relates to elastomeric lyotropic liquid crystal (E-LLC) and mesoporous elastomers, wherein the mesoporous elastomer possesses a combination of covalent chemical crosslinks and physical chain entanglement crosslinks. The production and use such mesoporous elastomers is also provided.

Abstract: Provided are methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-negative bacteria, including Klebsiella, Enterobacter, and Pseudomonas, and related conditions. The compositions and methods utilize Klebsiellapneumonia, Enterobacter, and Pseudomonas derived bacteriophage lysins, and variants thereof, including truncations thereof.

Abstract: A method comprising an arc ignition phase (IP), an arc-stabilizing phase (AP) and a stable arc phase (SP). The arc stabilizing phase comprises an initial sub-phase (IS) comprising the step of feeding at least one hot wire (4, 12) at constant feed speed and a main sub-phase (MS) comprising the steps of feeding said hot wire at constant feed speed and feeding at least one cold wire (22) at constant feed speed. The stable arc phase comprises the steps of continuously adjusting the feed speed of the hot wire and continuously adjusting the feed speed of the cold wire. The invention also relates to a welding apparatus (1) for carrying out the method. The welding apparatus comprises a hot wire feeding means (150), a contact means (2), a cold wire feeding means (35) and a control unit (31).

Abstract: The invention provides novel 6-heterocyclyl-4-morpholin-4-yl-pyridine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and A are as defined in the specification.