Patents by Inventor Martin Aryee

Martin Aryee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for Detecting Liver Diseases
    Publication number: 20220033910
    Abstract: The present invention relates to methods for diagnosing, determining, or monitoring liver diseases and conditions based on the blood concentration of circulating epithelial cells in and their gene expression.
    Type: Application
    Filed: September 11, 2019
    Publication date: February 3, 2022
    Inventors: David T. Ting, Irun Bhan, Kelly Mosesso, Martin Aryee
  • DNA METHYLATION MARKERS FOR METASTATIC PROSTATE CANCER
    Publication number: 20190367990
    Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (TM) and allele-specific methylation (ASM) alternation, This method, called MBD-SNP, features affinity enrichment or methylated genomic DNA fragments using a methyl-binding domain polypeptide.
    Type: Application
    Filed: December 20, 2018
    Publication date: December 5, 2019
    Inventors: Srinivasan Yegnasubramanian, G. Steven Bova, Martin Aryee, William B. Isaacs, William G. Nelson
  • DNA methylation markers for metastatic prostate cancer
    Patent number: 10196698
    Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (TM) and allele-specific methylation (ASM) alternation, This method, called MBD-SNP, features affinity enrichment or methylated genomic DNA fragments using a methyl-binding domain polypeptide.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: February 5, 2019
    Assignee: The Johns Hopkins University
    Inventors: Srinivasan Yegnasubramanian, G. Steven Bova, Martin Aryee, William B. Isaacs, William G. Nelson
  • DNA METHYLATION MARKERS FOR METASTATIC PROSTATE CANCER
    Publication number: 20180100196
    Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (TM) and allele-specific methylation (ASM) alternation, This method, called MBD-SNP, features affinity enrichment or methylated genomic DNA fragments using a methyl-binding domain polypeptide.
    Type: Application
    Filed: May 18, 2017
    Publication date: April 12, 2018
    Inventors: Srinivasan Yegnasubramanian, G. Steven Bova, Martin Aryee, William B. Isaacs, William G. Nelson
  • DNA METHYLATION MARKERS FOR METASTATIC PROSTATE CANCER
    Publication number: 20140274767
    Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (TM) and allele-specific methylation (ASM) alternation, This method, called MBD-SNP, features affinity enrichment or methylated genomic DNA fragments using a methyl-binding domain polypeptide.
    Type: Application
    Filed: January 23, 2014
    Publication date: September 18, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Srinivasan Yegnasubramanian, G. Steven Bova, Martin Aryee, William B. Isaacs, William G. Nelson