Abstract: Herein is reported a method for the production of a polypeptide that is biologically active as n-mer comprising a nucleic acid encoding a fusion polypeptide according to the following formula (Bn-CSo-Is-CSp-FC-CSq-It-CSr-Bm)u, wherein B denotes a polypeptide that is biologically active as n-mer and forms non-defined aggregates/multimers upon expression in the absence of a fused Fc-region, FC denotes a heavy chain Fc-region polypeptide, CS denotes a cleavage site, and I denotes an intervening amino acid sequence, wherein FC does not substantially bind to an Fc-receptor, recovering the fusion polypeptide from the cell or the cultivation medium, optionally cleaving the fusion polypeptide with a protease, and thereby producing a polypeptide that is biologically active as n-mer and forms non-defined aggregates/multimers upon expression in the absence of a fused Fc-region.

Abstract: A computer-implemented method for execution by a processor of a computing device. The method comprises implementing a computerized graphical user interface (GUI) that provides a user of the computing device with an opportunity to identify a pharmaceutical compounding formula; consulting a database at least partly on a basis of the identified pharmaceutical compounding formula in order to determine mixing parameters for a planetary mixer, associated with the identified pharmaceutical compounding formula; and causing a mixer to subject a container to superimposed rotation and revolution movements in accordance with the mixing parameters determined from consulting the database.

Abstract: The invention relates to a lighting arrangement comprising: a housing (1) extending along a longitudinal axis (L); an LED light source (2) for generating a light, arranged within the housing (1) and extending along the longitudinal axis (L), wherein a lighting outlet opening (3) for the light is delimited by the housing (1); a sensor (4), in particular for detecting a brightness and/or a movement in a vicinity of the lighting arrangement; and a support element (5) for the sensor (4), which is configured to be arranged in the housing (1) in different longitudinal positions relative to the LED light source (2) with respect to the longitudinal axis (L).

Abstract: A fluid dispenser, comprising: an actuator with a rotatable dial; a valve assembly connected to the actuator, the valve assembly being configured so as to cause fluid to be drawn from a reservoir and released from the dispenser during at least part of the time when the dial is rotated from a start position to one of a plurality of dosage positions and back to the start position, the plurality of dosage positions being at different respective angular positions of the dial; the actuator being configured to provide perceptible feedback at each of the plurality of dosage positions.

Abstract: The invention relates to a strip light system, having an elongated carrier rail (1), which extends along a longitudinal axis (L) and has a U shape in a cross section normal to the longitudinal axis (L) as viewed in a first approximation, so that a first U leg (2), a second U leg (3) and a connecting leg (4), which connects the two U legs (2, 3) to one another, are formed, wherein at least one pass-through opening (5, 5?) is formed in the connecting leg (4), and also having at least one luminaire, which is designed to be connected to the carrier rail (1), wherein at least one cover element (6), which is designed to be mounted on the carrier rail (1) so as to cover the at least one pass-through opening (5, 5?), is provided.

Abstract: Herein is reported a method for the production of a polypeptide that is biologically active as n-mer comprising a nucleic acid encoding a fusion polypeptide according to the following formula (Bn-CSo-Is-CSp-FC-CSq-It-CSr-Bm)u, wherein B denotes a polypeptide that is biologically active as n-mer and forms non-defined aggregates/multimers upon expression in the absence of a fused Fc-region, FC denotes a heavy chain Fc-region polypeptide, CS denotes a cleavage site, and I denotes an intervening amino acid sequence, wherein FC does not substantially bind to an Fc-receptor, recovering the fusion polypeptide from the cell or the cultivation medium, optionally cleaving the fusion polypeptide with a protease, and thereby producing a polypeptide that is biologically active as n-mer and forms non-defined aggregates/multimers upon expression in the absence of a fused Fc-region.

Abstract: The invention relates to a mounting device (1) for mounting holding rails (4a, 4b) for lamp housings to cut-outs (3) of suspended walls or ceilings, comprising a substantially rigid frame (15) and, connected thereto, a first holder (2a) for retaining a first holding rail (4a) and a second holder (2b) for retaining a second holding rail (4b), wherein the holders (2a, 2b) are designed to hold the holding rails (4a, 4b) parallel to and at a defined distance from each other. The invention further relates to a mounting system, comprising a mounting device (1) according to the invention and at least two holding rails (4a, 4b).

Abstract: Herein is reported a method for the production of a polypeptide that is biologically active as n-mer comprising a nucleic acid encoding a fusion polypeptide according to the following formula (Bn-CSo-Is-CSp-FC-CSq-ItCSr-Bm)u, wherein B denotes a polypeptide that is biologically active as n-mer and forms non-defined aggregates/multimers upon expression in the absence of a fused Fc-region, FC denotes a heavy chain Fc-region polypeptide, CS denotes a cleavage site, and I denotes an intervening amino acid sequence, wherein FC does not substantially bind to an Fc-receptor, recovering the fusion polypeptide from the cell or the cultivation medium, optionally cleaving the fusion polypeptide with a protease, and thereby producing a polypeptide that is biologically active as n-mer and forms non-defined aggregates/multimers upon expression in the absence of a fused Fc-region.

Abstract: The invention relates to a cover for covering a light outlet opening (4) limited by a support rail (1) of a lighting strip system, the support rail (1) being designed to receive a lamp (2) having a light source (3) for producing light, wherein the cover (5) has a holding device (6) for holding at least one optically active element (7) for influencing the light.

Abstract: The invention relates to a lighting-means carrier (5) for a strip-lighting luminaire, comprising: at least one lighting-means circuit board (30) having light-emitting diodes (33) that can be arranged thereon; and at least one heat sink (31) thermally connected to the lighting-means circuit board (30). In a central region, the lighting-means circuit board (30) is rigidly connected to the heat sink (31) in such a way that substantially no relative motion between the lighting-means circuit board (30) and the heat sink (31) is possible. In at least two further regions, the lighting-means circuit board (30) is connected to the heat sink (31) in a floating manner, the lighting-means circuit board (30) therefore being arranged on the heat sink (31) in such a way that the lighting-means circuit board can be moved in relation to the heat sink (31) outside of the central region. The invention further relates to a strip-lighting luminaire having at least one lighting-means carrier (5) according to the invention.

Abstract: Bispecific tetravalent antibodies against IL-17 and TNFa, useful in therapy, e.g. the treatment of rheumatoid arthritis and other autoimmune diseases and/or to reduce pathological inflammatory conditions.

Abstract: The invention relates to a lighting means support (10) for a strip light luminaire, comprising: at least one spring element (20) for detachably connecting the lighting means support (10) to a strip light rail (1) of a strip light luminaire; wherein the at least one spring element (20) comprises at least one latching element (22) which can be brought into engagement with a correspondingly formed latching element or a correspondingly formed wall section (2) of the strip light rail (1) in order to latch the lighting means support (10) to the strip light rail (1) in such a way that movement of the lighting means support (10) counter to an insertion direction of the lighting means support (10) into the strip light rail (1) is prevented. The invention further relates to a strip light luminaire having at least one lighting means support (10) according to the invention.

Abstract: The present invention relates to a device carrier (10) for a strip-lighting luminaire, comprising: first lines (14) for forming a first power supply circuit; second lines (14) for forming a second power supply circuit; and at least one converter unit (12) for electrically coupling the first to the second power supply circuit, said converter unit being mounted on the device carrier (10). The first lines (14) are arranged on a rear face of the device carrier (10) so that the first lines (14) are concealed by the device carrier (10) in the mounted state of the strip-lighting luminaire. The invention further relates to a strip-lighting luminaire comprising at least one device carrier (10) according to the invention.

Abstract: A mounting system (1) for mounting a light fixture comprises two substantially L-shape designed receiving rails (4a, 4b). The receiving rails (4a, 4b) each have a first leg (5a, 5b) which is designed to be fastened to a front side of a suspended wall or an underside of a suspended ceiling (2) on a respective opposite edge of a recess (3) of the wall or ceiling (2). The receiving rails (4a, 4b) each further comprise a second leg (6a, 6b) which is designed to protrude into the recess (3) and to carry a light fixture housing (10) of the light fixture, but without connecting the light housing (1) rigidly to the first legs (5a, 5b) of the receiving rails (4a, 4b).

Abstract: Herein is reported a non-covalent complex of a haptenylated antibody that specifically binds to human tau(pS422) and an anti-blood brain barrier receptor/hapten bispecific antibody.

Abstract: The present disclosure relates to a system and process for manufacturing patient personalized pharmaceutical compositions using superimposed revolution and rotation movements for dispersing, milling, melting, and/or de-aerating, where these superimposed revolution and rotation movements can be carried out in a single device in a pharmacy setting.

Abstract: The invention relates to a strip light system, having an elongated carrier rail (1), which extends along a longitudinal axis (L) and has a U shape in a cross section normal to the longitudinal axis (L) as viewed in a first approximation, so that a first U leg (2), a second U leg (3) and a connecting leg (4), which connects the two U legs (2, 3) to one another, are formed, wherein at least one pass-through opening (5, 5?) is formed in the connecting leg (4), and also having at least one luminaire, which is designed to be connected to the carrier rail (1), wherein at least one cover element (6), which is designed to be mounted on the carrier rail (1) so as to cover the at least one pass-through opening (5, 5?), is provided.

Abstract: The invention relates to a lighting arrangement comprising: a housing (1) extending along a longitudinal axis (L); an LED light source (2) for generating a light, arranged within the housing (1) and extending along the longitudinal axis (L), wherein a lighting outlet opening (3) for the light is delimited by the housing (1); a sensor (4), in particular for detecting a brightness and/or a movement in a vicinity of the lighting arrangement; and a support element (5) for the sensor (4), which is configured to be arranged in the housing (1) in different longitudinal positions relative to the LED light source (2) with respect to the longitudinal axis (L).