Patents by Inventor Martin Bechem
Martin Bechem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130300032Abstract: The present invention relates to an improved microplate which is constructed of at least one frame part and at least one bottom part, where the bottom part has a maximum thickness of 500 ?m.Type: ApplicationFiled: July 19, 2013Publication date: November 14, 2013Applicant: GREINER BIO-ONE GmbHInventors: Gunther Knebel, Martin Bechem, Werner Sturmer, Ralph Noll
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Patent number: 8512652Abstract: The present invention relates to an improved microplate which is constructed of at least one frame part and at least one bottom part, where the bottom part has a maximum thickness of 500 ?m.Type: GrantFiled: October 15, 2002Date of Patent: August 20, 2013Assignee: Greiner Bio-One GmbHInventors: Günther Knebel, Martin Bechem, Werner Stürmer, Ralph Noll
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Masking of the background fluorescence and luminescence in the optical analysis of biomedical assays
Patent number: 8178359Abstract: A process for the quantitative optical analysis of fluorescently labeled biological cells involves contacting a cell layer on a transparent support at the bottom of a reaction vessel with a solution containing the fluorescent dye. This process can also be used for improving the sensitivity in the quantitative optical analysis of a luminescent biological cell layer. Analogously, these process principles can also be used in receptor studies for the masking of the interfering background radiation in the quantitative optical analysis of fluorescently or luminescently labelled reaction components. In this case, a receptor layer at the bottom of a reaction vessel is in contact with a solution in which a fluorescent or luminescent ligand is dissolved.Type: GrantFiled: September 28, 2001Date of Patent: May 15, 2012Assignee: Bayer Healthcare AGInventors: Thoams Krahn, Wolfgang Paffhausen, Andreas Schade, Martin Bechem, Delf Schmidt -
Patent number: 7615376Abstract: In a process for the quantitative optical analysis of fluorescently labelled biological cells 5, a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact with a solution 3 containing the fluorescent dye 4. The sensitivity of analytical detection can be considerably improved if to the fluorescent dye 4 already present in addition a masking dye 9, which absorbs the excitation light 6 for the fluorescent dye 4 and/or its emission light 7, is added to the solution 3 and/or if a separating layer 10 permeable to the solution and absorbing and/or reflecting the excitation light 6 or the emission light 7 is applied to the cell layer at the bottom 2. This process can also be used for improving the sensitivity in the quantitative optical analysis of a luminescent biological cell layer. The separating layer 10 must in this case be composed such that it has a high power of reflection for the luminescent light 11.Type: GrantFiled: August 27, 2008Date of Patent: November 10, 2009Assignee: Bayer Schering Pharma AktiengesellschaftInventors: Thomas Krahn, Wolfgang Paffhausen, Andreas Schade, Martin Bechem, Delf Schmidt
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Publication number: 20080318270Abstract: In a process for the quantitative optical analysis of fluorescently labelled biological cells 5, a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact with a solution 3 containing the fluorescent dye 4. The sensitivity of analytical detection can be considerably improved if to the fluorescent dye 4 already present in addition a masking dye 9, which absorbs the excitation light 6 for the fluorescent dye 4 and/or its emission light 7, is added to the solution 3 and/or if a separating layer 10 permeable to the solution and absorbing and/or reflecting the excitation light 6 or the emission light 7 is applied to the cell layer at the bottom 2. This process can also be used for improving the sensitivity in the quantitative optical analysis of a luminescent biological cell layer. The separating layer 10 must in this case be composed such that it has a high power of reflection for the luminescent light 11.Type: ApplicationFiled: August 27, 2008Publication date: December 25, 2008Applicant: BAYER HEALTHCARE AGInventors: Thomas Krahn, Wolfgang Paffhausen, Andreas Schade, Martin Bechem, Delf Schmidt
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Masking of the background fluorescence and luminescence in the optical analysis of biomedical assays
Patent number: 7138280Abstract: In a process for the quantitative optical analysis of biological cells labelled with a fluorescent dye, the sensitivity of analytical detection can be considerably improved if a masking dye, which absorbs the excitation light for the fluorescent dye and/or its emission light is added to the solution surrounding the biological cells and/or if a separating layer permeable to the solution and absorbing and/or reflecting the excitation light or the emission light is applied to a layer of the biological cells at the bottom of a reaction vessel. This process can also be used for improving the sensitivity in the quantitative optical analysis of a luminescent biological cell layer. Analogously, these process principles can also be used in receptor studies for the masking of the interfering background radiation in the quantitative optical analysis of fluorescently or luminescently labelled reaction components.Type: GrantFiled: October 3, 2002Date of Patent: November 21, 2006Assignee: Bayer Healthcare AGInventors: Thomas Krahn, Wolfgang Paffhausen, Andreas Schade, Martin Bechem, Delf Schmidt -
Publication number: 20060247244Abstract: The invention relates to quinoxalinones and to methods for producing the same as well as the use thereof for preparing drugs for the treatment and/or prophylaxis of diseases, especially of cardiovascular diseases.Type: ApplicationFiled: January 27, 2003Publication date: November 2, 2006Applicant: BAYER HEALTHCARE AGInventors: Jens-Kerim Ergüden, Peter Kolkhof, Julio Castro-Palomino, Alexander Kuhl, Raimund Kast, Johannes-Peter Stasch, Hanna Tinel, Klaus Münter, Klemens Lustig, Josef Pernerstorfer, Martin Bechem, Jörg Hüser
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Patent number: 7063952Abstract: In a process for the quantitative optical analysis of fluorescently labelled biological cells 5, a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact with a solution 3 containing the fluorescent dye 4. The sensitivity of analytical detection can be considerably improved if to the fluorescent dye 4 already present in addition a masking dye 9, which absorbs the excitation light 6 for the fluorescent dye 4 and/or its emission light 7, is added to the solution 3 and/or if a separating layer 10 permeable to the solution and absorbing and/or reflecting the excitation light 6 or the emission light 7 is applied to the cell layer at the bottom 2. This process can also be used for improving the sensitivity in the quantitative optical analysis of a luminescent biological cell layer. The separating layer 10 must in this case be composed such that it has a high power of reflection for the luminescent light 11.Type: GrantFiled: September 28, 2001Date of Patent: June 20, 2006Assignee: Bayer Healthcare AGInventors: Thoams Krahn, Wolfgang Paffhausen, Andreas Schade, Martin Bechem, Delf Schmidt
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Patent number: 6985225Abstract: The invention relates to a fluorescence-measuring system as can be employed for high-throughput screening in drug development. The arrangement for fluorescence excitation contains a two-dimensionally extended sample-receiving device and at least two illumination sources for exciting the fluorescence of the samples. The illumination sources are extended linearly and arranged in such a way that the illuminated area of the sample-receiving device is homogeneously illuminated directly or via deflecting mirrors at an opening angle of ?30°.Type: GrantFiled: May 22, 2003Date of Patent: January 10, 2006Assignee: Bayer HealthCare AktiengesellschaftInventors: Martin Bechem, Wolfgang Paffhausen
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Patent number: 6867206Abstract: The present invention relates to 6-carboxyphenyldihydropyridazinone derivatives having the formula wherein R1, R2, R3, A, D, G, and E are as defined in the specification and claims, a process for preparing these materials, pharmaceutical compositions containing them, and a method for using them in the treatment of anemias.Type: GrantFiled: June 16, 2000Date of Patent: March 15, 2005Assignee: Bayer AktiengesellschaftInventors: Jürgen Stoltefuss, Gabriele Bräunlich, Michael Lögers, Carsten Schmeck, Ulrich Nielsch, Martin Bechem, Christoph Gerdes, Michael Sperzel, Klemens Lustig, Werner Stürmer
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Patent number: 6699857Abstract: The invention relates to the area of erythropoiesis, in particular to the use of tetrahydroquinolinyl-6-methyldihydrothiadiazinones of general formula (I) for treating anaemia. The invention also relates to novel tetrahydroquinolinyl-6-methyldihydrothiadiazinone derivatives and to the production thereof.Type: GrantFiled: April 1, 2002Date of Patent: March 2, 2004Assignee: Bayer AktiengesellschaftInventors: Jürgen Stoltefuss, Gabriele Bräunlich, Michael Lögers, Carsten Schmeck, Ulrich Nielsch, Martin Bechem, Christoph Gerdes, Michael Sperzel, Klemens Lustig, Werner Stürmer
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Publication number: 20040032589Abstract: The invention relates to a fluorescence-measuring system as can be employed for high-throughput screening in drug development. The arrangement for fluorescence excitation contains a two-dimensionally extended sample-receiving device and at least two illumination sources for exciting the fluorescence of the samples. The illumination sources are extended linearly and arranged in such a way that the illuminated area of the sample-receiving device is homogeneously illuminated directly or via deflecting mirrors at an opening angle of ≦30°.Type: ApplicationFiled: May 22, 2003Publication date: February 19, 2004Inventors: Martin Bechem, Wolfgang Paffhausen
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Masking of the background fluorescence and luminescence in the optical analysis of biomedical assays
Publication number: 20030092081Abstract: In a process for the quantitative optical analysis of fluorescently labelled biological cells 5, a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact with a solution 3 containing the fluorescent dye 4. The sensitivity of analytical detection can be considerably improved if to the fluorescent dye 4 already present in addition a masking dye 9, which absorbs the excitation light 6 for the fluorescent dye 4 and/or its emission light 7, is added to the solution 3 and/or if a separating layer 10 permeable to the solution and absorbing and/or reflecting the excitation light 6 or the emission light 7 is applied to the cell layer at the bottom 2. This process can also be used for improving the sensitivity in the quantitative optical analysis of a luminescent biological cell layer. The separating layer 10 must in this case be composed such that it has a high power of reflection for the luminescent light 11.Type: ApplicationFiled: October 3, 2002Publication date: May 15, 2003Inventors: Thomas Krahn, Wolfgang Paffhausen, Andreas Schade, Martin Bechem, Delf Schmidt -
Patent number: 6420183Abstract: In a process for the quantitative optical analysis of fluorescently labelled biological cells 5, a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact with a solution 3 containing the fluorescent dye 4. The sensitivity of analytical detection can be considerably improved if to the fluorescent dye 4 already present in addition a masking dye 9, which absorbs the excitation light 6 for the fluorescent dye 4 and/or its emission light 7, is added to the solution 3 and/or if a separating layer 10 permeable to the solution and absorbing and/or reflecting the excitation light 6 or the emission light 7 is applied to the cell layer at the bottom 2. The separating layer 10 must be composed such that it has a high power of reflection for the luminescent light 11.Type: GrantFiled: November 20, 1998Date of Patent: July 16, 2002Assignee: Bayer AktiengesellschaftInventors: Thoams Krahn, Wolfgang Paffhausen, Andreas Schade, Martin Bechem, Delf Schmidt
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Publication number: 20020022274Abstract: In a process for the quantitative optical analysis of fluorescently labelled biological cells 5, a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact with a solution 3 containing the fluorescent dye 4. The sensitivity of analytical detection can be considerably improved if to the fluorescent dye 4 already present in addition a masking dye 9, which absorbs the excitation light 6 for the fluorescent dye 4 and/or its emission light 7, is added to the solution 3 and/or if a separating layer 10 permeable to the solution and absorbing and/or reflecting the excitation light 6 or the emission light 7 is applied to the cell layer at the bottom 2. This process can also be used for improving the sensitivity in the quantitative optical analysis of a luminescent biological cell layer. The separating layer 10 must in this case be composed such that it has a high power of reflection for the luminescent light 11.Type: ApplicationFiled: November 20, 1998Publication date: February 21, 2002Inventors: THOMAS KRAHN, WOLFGANG PAFFHAUSEN, ANDREAS SCHADE, MARTIN BECHEM, DELF SCHMIDT
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Publication number: 20020015969Abstract: In a process for the quantitative optical analysis of fluorescently labelled biological cells 5, a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact with a solution 3 containing the fluorescent dye 4. The sensitivity of analytical detection can be considerably improved if to the fluorescent dye 4 already present in addition a masking dye 9, which absorbs the excitation light 6 for the fluorescent dye 4 and/or its emission light 7, is added to the solution 3 and/or if a separating layer 10 permeable to the solution and absorbing and/or reflecting the excitation light 6 or the emission light 7 is applied to the cell layer at the bottom 2. This process can also be used for improving the sensitivity in the quantitative optical analysis of a luminescent biological cell layer. The separating layer 10 must in this case be composed such that it has a high power of reflection for the luminescent light 11.Type: ApplicationFiled: September 28, 2001Publication date: February 7, 2002Inventors: Thomas Krahn, Wolfgang Paffhausen, Andreas Schade, Martin Bechem, Delf Schmidt
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Patent number: 6343906Abstract: An arrangement for transporting microtitration plates in an automatic handling machine is disclosed comprising at least one linear-transport device on which a carriage, which has at least one place of deposit for a microtitration plate, is transported in a straight line, under automatic control, between two limit positions. A lifting device is included with vertically displaceable bolts by which the microtitration plates can be lifted off or deposited on the carriage. At least one rotary device is also included in which a rotary element which has at least one resting place for a microtitration plate can be moved, under automatic control, about a fixed rotation shaft.Type: GrantFiled: November 18, 1999Date of Patent: February 5, 2002Assignee: CyBio Instruments GmbHInventors: Wolfgang Kraemer, Thomas Moore, Heiko Oehme, Georg Schmidt, Ralph Noll, Martin Bechem
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Masking of the background fluorescence and luminescence in the optical analysis of biomedical assays
Publication number: 20020009754Abstract: In a process for the quantitative optical analysis of fluorescently labelled biological cells 5, a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact with a solution 3 containing the fluorescent dye 4. The sensitivity of analytical detection can be considerably improved if to the fluorescent dye 4 already present in addition a masking dye 9, which absorbs the excitation light 6 for the fluorescent dye 4 and/or its emission light 7, is added to the solution 3 and/or if a separating layer 10 permeable to the solution and absorbing and/or reflecting the excitation light 6 or the emission light 7 is applied to the cell layer at the bottom 2. This process can also be used for improving the sensitivity in the quantitative optical analysis of a luminescent biological cell layer. The separating layer 10 must in this case be composed such that it has a high power of reflection for the luminescent light 11.Type: ApplicationFiled: September 28, 2001Publication date: January 24, 2002Inventors: Thoams Krahn, Wolfgang Paffhausen, Andreas Schade, Martin Bechem, Delf Schmidt -
Patent number: 6191852Abstract: In the measurement system for detecting optical signals of microassays, the signal-generating test objects 5 are arranged on an investigation surface of a planar carrier 4. The planar carrier 4 is, in particular, a microtitre plate for biological objects. In principle, the measurement system comprises an optical imaging arrangement which reduces the size of the test objects 4 to be measured in such a way that all the objects are imaged completely on a two-dimensional, photosensitive image sensor 6.Type: GrantFiled: October 13, 1998Date of Patent: February 20, 2001Assignee: Bayer AktiengesellschaftInventors: Wolfgang Paffhausen, Martin Bechem
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Patent number: 5721248Abstract: The invention relates to new 4-bicyclically substituted dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.5 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.Type: GrantFiled: May 10, 1996Date of Patent: February 24, 1998Assignee: Bayer AktiengesellschaftInventors: Alexander Straub, Siegfried Goldmann, Jurgen Stoltefuss, Martin Bechem, Klaus Dembowsky, Rainer Gross, Siegbert Hebisch, Joachim Hutter, Howard-Paul Rounding