Patents by Inventor Martin Bickel

Martin Bickel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of bradykinin antagonists for the production of pharmaceuticals for the treatment of chronic fibrogenetic liver disorders and acute liver disorders
    Patent number: 5863901
    Abstract: This invention relates to a method of treating a chronic fibrogenetic liver disorder and/or an acute liver disorder and/or complications associated therewith, comprising administering to a patient a therapeutically effective amount of a bradykinin antagonist. Particular complications associated with said liver disorders include portal hypertension, decompensation phenomena such as ascites, edema formation, hepatorenal syndrome, hypertensive gastropathy and colopathy, splenomegaly and hemorrhagic complications in the gastrointestinal tract due to portal hypertension, collateral circulation and hyperemia and a cardiopathy as a result of a chronically hyperdynamic circulatory situation and its consequences.
    Type: Grant
    Filed: March 4, 1997
    Date of Patent: January 26, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Breipohl, Stephan Henke, Jochen Knolle, Klaus Wirth, Max Hropot, Martin Bickel
  • Method of blocking nerve conduction by treatment with branched-chain esters of 2-?4-(2-piperidine-ethoxy)-benzoyl!-benzoic acid and pharmaceutically acceptable salts thereof
    Patent number: 5821252
    Abstract: Compounds of the formula III ##STR1## in which R.sub.4 and R.sub.5 are CH.sub.3 amd R.sub.6 is hydrogen, have prolonged spasmolytic and anaesthetic activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 13, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Swati Bal-Tembe, Jurgen Blumbach, Alihussein Nomanbhai Dohadwalla, deceased, Bansi Lal, Narayan Sudhindra Punekar, Ramanujam Rajgopalan, Richard Helmut Rupp, Martin Bickel
  • Use of nonpeptide bradykinin antagonists for the treatment and prevention of chronic fibrogenetic liver disorders, acute liver disorders and the complications associated therewith
    Patent number: 5786365
    Abstract: The invention relates to the use of nonpeptide bradykinin antagonists for the production of pharmaceuticals for the treatment of chronic fibrogenetic liver disorders (hepatic cirrhosis and hepatic fibrosis), acute liver disorders and for the prevention of complications, in particular for the prophylaxis or treatment of portal hypertension, decompensation symptoms such as ascites, edema formation, hepatorenal syndrome, hypertensive gastropathy and colopathy, splenomegaly and hemorrhagic complications in the gastrointestinal tract due to portal hypertension, collateral circulation and hyperemia and a cardiopathy as a result of a chronically hyperdynamic circulatory situation and its consequences.
    Type: Grant
    Filed: May 19, 1997
    Date of Patent: July 28, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Holger Heitsch, Adalbert Wagner, Klaus Wirth, Max Hropot, Martin Bickel
  • Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates
    Patent number: 5726305
    Abstract: The invention relates to substituted quinoline-2-carboxylic acid amides of the formula I ##STR1## their preparation and their use, and intermediates which are formed in the preparation of the compounds of the formula I. The compounds according to the invention are used as inhibitors of prolyl 4-hydroxylase and as pharmaceuticals (medicaments) for treatment of fibrotic diseases.
    Type: Grant
    Filed: July 3, 1996
    Date of Patent: March 10, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Weidmann, Karl-Heinz Baringhaus, Georg Tschank, Martin Bickel
  • Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates
    Patent number: 5719164
    Abstract: The invention relates to substituted quinoline-2-carboxylic acid amides of the formula I ##STR1## their preparation and their use, and intermediates which are formed in the preparation of the compounds of the formula I. The compounds according to the invention are used as inhibitors of prolyl 4-hydroxylase and as pharmaceuticals (medicaments) for treatment of fibrotic diseases.
    Type: Grant
    Filed: July 3, 1996
    Date of Patent: February 17, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Weidmann, Karl-Heinz Baringhaus, Georg Tschank, Martin Bickel
  • Pharmaceutical use of pyridine-2,4- and -2,5-dicarboxylic acid amides
    Patent number: 5672614
    Abstract: The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medicaments for influencing the metabolism of collagen and collagen-like substances or the biosynthesis of Cl.sub.q.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 30, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Martin Bickel, Dietrich Brocks, Harald Burghard, Volkmar Gunzler, Stephan Henke, Hartmut Hanauske-Abel, Jurgen Mohr, Georg Tschank
  • Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals
    Patent number: 5658933
    Abstract: The invention relates to compounds of the formula I, ##STR1## to a process for their preparation and to their use as pharmaceuticals. The compounds are employed, in particular, as ester prodrugs of prolyl hydroxylase inhibitors for inhibiting collagen biosynthesis and as fibrosuppressive agents.
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: August 19, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Weidmann, Karl-Heinz Baringhaus, Georg Tschank, Martin Bickel
  • Substituted heterocyclic carboxyamides, their preparation and their use as pharmaceuticals
    Patent number: 5620995
    Abstract: The invention relates to compounds of the formula I, to a process for their preparation and to their use as pharmaceuticals. ##STR1## In particular, the compounds are used as inhibitors of prolyl-4-hydroxylase and as inhibitors of collagen biosynthesis, as pharmaceuticals against fibrotic diseases of the liver, the lung and the skin.
    Type: Grant
    Filed: December 28, 1994
    Date of Patent: April 15, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Weidmann, Karl-Heinz Baringhaus, Georg Tschank, Martin Bickel
  • Sulfonamidocarbonyl pyridine-2-carboxesteramides and their pyridine-N-oxide compounds and their use as pharmaceuticals
    Patent number: 5620996
    Abstract: The invention relates to sulfonamidocarbonylpyridine-2-carboxesteramides and their pyridine-N-oxides according to the formula I ##STR1## Said compounds are used as pharmaceuticals against fibrotic disorders, as fibrosuppressants and as inhibitors of proline hydroxylase.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: April 15, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Weidmann, Martin Bickel, Volkmar G unzler-Pukall
  • 2,4-and 2,5-bistetrazolylpyridines, a process for the preparation thereof and the use thereof as pharmaceuticals
    Patent number: 5614537
    Abstract: The invention relates 2,4- and 2,5-bistetrazolylpyridines. Said compounds inhibit the enzymes proline hydroxylase and lysine hydroxylase and bring about a selective inhibition of collagen biosynthesis. They are used as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 25, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerrit Schubert, Ekkehard Baader, Martin Bickel, Volkmar G unzler-Pukall
  • Sulfonamidocarbonylpyridine-2-carboxamides and pyridine-n-oxides which are useful as pharmaceuticals
    Patent number: 5610172
    Abstract: Sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation, and their use as pharmaceuticalsThe invention relates to sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-N-oxides according to the formula I ##STR1## Said compounds are used as pharmaceuticals against fibrotic disorders, as fibrosuppressants and as inhibitors of proline hydroxylase and of collagen biosynthesis.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: March 11, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Weidmann, Martin Bickel, Volkmar G unzler-Pukall
  • Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals
    Patent number: 5607954
    Abstract: The invention relates to sulfonamido- and sulfonamido-carbonylpyridine-2-carboxa of the formula I ##STR1## and their use as pharmaceuticals, in particular against fibrotic diseases.
    Type: Grant
    Filed: December 13, 1994
    Date of Patent: March 4, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Weidmann, Martin Bickel, Volkmar G unzler-Pukall
  • N,N'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamines
    Patent number: 5519038
    Abstract: The invention relates to N,N'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamides of the formula I ##STR1## wherein R.sup.1, R.sup.2, n, R.sup.1', R.sup.2' and n' have the meanings given. The compounds inhibit proline hydroxylase and lysine hydroxylase and are suitable as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: March 9, 1995
    Date of Patent: May 21, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Martin Bickel, Volkmar Gunzler-Pukall
  • Medicaments based on pyridine-2,4- and 2,5-dicarboxylic acid amides
    Patent number: 5512586
    Abstract: The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2, 3.sup.3, R.sup.4 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medicaments for influencing the metabolism of collagen and collagen-like substances or the biosynthesis of Cl.sub.q.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: April 30, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Martin Bickel, Dietrich Brocks, Harald Burghard, Volkmar Gunzler, Stephan Henke, Hartmut Hanauske-Abel, Jurgen Mohr, Georg Tschank
  • 2,4-and 2,5-bistetrazolylpyridines and the use thereof as pharmaceuticals
    Patent number: 5482953
    Abstract: The invention relates to 2,4- and 2,5-bistetrazolylpyridines. Said compounds inhibit the enzymes proline hydroxylase and lysine hydroxylase and bring about a selective inhibition of collagen biosynthesis. They are used as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: January 9, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerrit Schubert, Ekkehard Baader, Martin Bickel, Volkmar Gunzler-Pukall
  • Acylsulfonamido- and sulfonamidopyridine-2-carboxylic acid esters and their pyridine N-oxides, processes for their preparation and their use as medicaments
    Patent number: 5428046
    Abstract: The invention relates to acylsulfonamido- and sulfonamidopyridine-2-carboxylic acid esters and their pyridine N-oxides of the formula I ##STR1## in which______________________________________ A = R.sup.3 and B = X--NR.sup.5 R.sup.6 or B = R.sup.3 and A = X--NR.sup.5 R.sup.6. ______________________________________The compounds are suitable as medicaments against fibrotic diseases.
    Type: Grant
    Filed: September 22, 1993
    Date of Patent: June 27, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Weidmann, Martin Bickel, Volkmar Gunzler-Pukall, Karl-Heinz Baringhaus
  • Pyridine-2,4- and dicarboxylic acid derivatives, the use thereof and pharmaceutical composition based on these compounds
    Patent number: 5364873
    Abstract: The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medicaments for influencing the metabolism of collagen and collagen-like substances or the biosynthesis of C1.sub.q.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: November 15, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Martin Bickel, Dietrich Brocks, Harald Burghard, Volkmar Gunzier, Stephan Henke
  • Substituted pyridine-2,4-dicarboxylic acid compounds and the use thereof and medicaments
    Patent number: 5356909
    Abstract: The invention relates to substituted pyridine-2,4-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings given. The invention also relates to a process for the preparation of the abovementioned compounds and to their use as medicaments, in particular as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: June 25, 1992
    Date of Patent: October 18, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Martin Bickel, Dietrich Brocks, Volkmar Gunzler, Stephan Henke, Hartmut Hanauske-Abel
  • 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use
    Patent number: 5260323
    Abstract: 2,4- and 2,5-substituted pyridine-N-oxides are provided which are effective as fibrosuppressives and immunosuppressives. Said compounds are also suitable for the treatment of disorders of the metabolism of collagen and collagen-like substances or the biosynthesis of Clq.
    Type: Grant
    Filed: November 19, 1992
    Date of Patent: November 9, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Martin Bickel, Volkmar Gunzler-Pukall
  • Cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides, processes for their preparation and their use
    Patent number: 5240921
    Abstract: The invention relates to cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides of the formula I ##STR1## in which n and X have the meanings given. The compounds according to the invention inhibit proline hydroxylase and lysine hydroxylase and can accordingly be employed as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: August 23, 1990
    Date of Patent: August 31, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Martin Bickel, Volkmar Gunzler-Pukall