Patents by Inventor Martin Bobek

Martin Bobek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9999678
    Abstract: The invention relates to a method of preparation hydrophobized hyaluronic acid (Formula I) and further to a method of encapsulating biologically active substances into the nanomicelles of hydrophobized hyaluronan serving as carriers of biologically active hydrophobic substances. The hydrophobization of hyaluronan is carried out through an esterification reaction of hyaluronan with long-chain carboxylic acids, the latter being activated by a halogenide derivative of 2,4,6-trichlorobenzoic acid or by another organic chloride. In an aqueous environment, water-soluble hydrophobized derivatives can form nanomicelles in which nonpolar substances can be bound by means of non-covalent physical interactions. The core of a nanomicelle is formed by hydrophobic acyl functional groups while the shell of a nanomicelle is formed by hyaluronic acid. The encapsulation of the substances into nanomicelles can be performed by means of the solvent exchange method or by means of sonication.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: June 19, 2018
    Assignee: Contipro a.s.
    Inventors: Daniela Smejkalova, Gloria Huerta-Angeles, Martin Bobek, Martina Hermannova, Lucie Vistejnova, Jaroslav Novotny, Eva Prikopova, Kristina Nesporova, Miroslava Nemcova, Klara Slezingrova, Jaromir Kulhanek, Dagmar Cozikova, Jana Sogorkova, Jan Kucera, Pavel Klein, Vladimir Velebny
  • Publication number: 20160312385
    Abstract: The invention relates to nanofibers containing photocurable ester derivatives of hyaluronic acid or its salt, the method of preparation thereof, and the photocured preparation made from the nanofibers by light irradiation and the use thereof
    Type: Application
    Filed: November 21, 2014
    Publication date: October 27, 2016
    Inventors: Gloria Huerta-Angeles, Martin Bobek, Eva Prikopova, Jana Ruzickova, Martina Moravcova, Martina Brandejsova, Vladimir Velebny
  • Publication number: 20150320873
    Abstract: The invention relates to a method of preparation hydrophobized hyaluronic acid (Formula I) and further to a method of encapsulating biologically active substances into the nanomicelles of hydrophobized hyaluronan serving as carriers of biologically active hydrophobic substances. The hydrophobization of hyaluronan is carried out through an esterification reaction of hyaluronan with long-chain carboxylic acids, the latter being activated by a halogenide derivative of 2,4,6-trichlorobenzoic acid or by another organic chloride. In an aqueous environment, water-soluble hydrophobized derivatives can form nanomicelles in which nonpolar substances can be bound by means of non-covalent physical interactions. The core of a nanomicelle is formed by hydrophobic acyl functional groups while the shell of a nanomicelle is formed by hyaluronic acid. The encapsulation of the substances into nanomicelles can be performed by means of the solvent exchange method or by means of sonication.
    Type: Application
    Filed: November 26, 2013
    Publication date: November 12, 2015
    Inventors: Daniela Smejkalova, Gloria Huerta-Angeles, Martin Bobek, Martina Hermannova, Lucie Vistejnova, Jaroslav Novotny, Eva Prikopova, Kristina Nesporova, Miroslava Nemcova, Klara Slezingrova, Jaromir Kulhanek, Dagmar Cozikova, Jana Sogorkova, Jan Kucera, Pavel Klein, Vladimir Velebny
  • Publication number: 20150308016
    Abstract: The invention relates to the biodegradable fibres which are based on hydrophobic derivatives of hylauronan, specifically on the base of the hyaluronan derivative C11-C18-acylated on hydroxyl groups of hyaluronic acid, and use thereof. Further the invention relates to the preparation of these fibres which is performed with the use of the wet spinning method in a coagulation bath comprising water solution of organic acid, with the production of continuous monofiles which can be thereafter processed to threads and further to textiles, knitted textiles, or nonwoven textiles. These textiles, knitted textiles or nonwoven textiles can be used for example for the production of implantable surgical material for human and veterinary medicine.
    Type: Application
    Filed: November 26, 2013
    Publication date: October 29, 2015
    Applicant: CONTIPRO BIOTECH S.R.O.
    Inventors: Jolana Scudlova, Jiri Betak, Lucie Wolfova, Radovan Buffa, Klara Slezingrova, Pavel Klein, Ilona Matejkova, Martin Bobek, Tomas Pitucha, Vladimir Velebny, Romana Sulakova