Patents by Inventor Martin Borrok II

Martin Borrok II has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecules with Reduced Effector Function and Extended Half-Lives, Compositions, and Uses Thereof
    Publication number: 20180258178
    Abstract: Provided are polypeptides comprising a variant IgG Fc domain, wherein the polypeptides exhibit reduced or ablated effector functions (e.g., ADCC and/or CDC) and increased stability and plasma half-life compared to a parent polypeptide. Also provided are compositions, methods of treatment, and methods to diminish Fc-induced effector function in a parent polypeptide.
    Type: Application
    Filed: May 23, 2018
    Publication date: September 13, 2018
    Inventors: Ping Tsui, Martin Borrok, II, William Dall'Acqua
  • Molecules with reduced effector function and extended half-lives, compositions, and uses thereof
    Patent number: 10011660
    Abstract: Provided are polypeptides comprising a variant IgG Fc domain, wherein the polypeptides exhibit reduced or ablated effector functions (e.g., ADCC and/or CDC) and increased stability and plasma half-life compared to a parent polypeptide. Also provided are compositions, methods of treatment, and methods to diminish Fc-induced effector function in a parent polypeptide.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: July 3, 2018
    Assignee: MedImmune, LLC
    Inventors: Ping Tsui, Martin Borrok, II, William Dall'Acqua
  • Molecules with Reduced Effector Function and Extended Half-Lives, Compositions, and Uses Thereof
    Publication number: 20150125444
    Abstract: Provided are polypeptides comprising a variant IgG Fc domain, wherein the polypeptides exhibit reduced or ablated effector functions (e.g., ADCC and/or CDC) and increased stability and plasma half-life compared to a parent polypeptide. Also provided are compositions, methods of treatment, and methods to diminish Fc-induced effector function in a parent polypeptide.
    Type: Application
    Filed: April 17, 2013
    Publication date: May 7, 2015
    Inventors: Ping Tsui, Martin Borrok II, William Dall'Acqua