Abstract: A lateral flow assay device of the present disclosure has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The device also can have a gasket to ensure free air movement between open vent pockets. Flow control features that protrude horizontally into a chamber proximal to an outlet act to deflect the flow to the side of the chamber opposite from the outlet, prior to the flow entering the outlet. Such features can reduce the flow velocity of the sample fluid and increase the effective fluid flow path length, enhance mixing of reagents with a sample, and enabling more accurate control of fluid flow in the device.

Abstract: An automated method for performing an assay of the present disclosure can be performed in a microfluidic device that is a lateral flow device having numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. Each chamber can have a reagent recess proximal to an inlet end of the chamber. A reagent pellet formed in a reagent recess can be effectively mixed with a sample as the sample flows into the chamber. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with, for example, a chamber for performing an amplification reaction.

Abstract: The disclosure relates to systems, methods and apparatus of storing, transporting, mixing, and injecting a drug as a solution, and in some embodiments, to a drug injection apparatus and system intended for use in mixing on demand a drug with a liquid, such as water, in a premeasured quantity and dosage, and injecting the drug mixture using an integrated hypodermic needle assembly. Also provided are methods of using such apparatus and systems.

Abstract: The instruments and methods of the present disclosure include an outer shaft, an inner shaft, a roller, and an actuator. In some examples, the outer shaft includes a lumen extending from a proximal end to a distal end. The inner shaft is disposed within the lumen. The roller rotatably is coupled with the distal end at an axis and configured to engage the fixation rod. The actuator operably couples with the inner shaft to translate the inner shaft within the lumen and cause rotation of the roller to impart linear movement on the fixation rod.

Abstract: The instruments and methods of the present disclosure include an outer shaft, an inner shaft, a roller, and an actuator. In some examples, the outer shaft includes a lumen extending from a proximal end to a distal end. The inner shaft is disposed within the lumen. The roller rotatably is coupled with the distal end at an axis and configured to engage the fixation rod. The actuator operably couples with the inner shaft to translate the inner shaft within the lumen and cause rotation of the roller to impart linear movement on the fixation rod.

Abstract: The instruments and methods of the present disclosure include an outer shaft, an inner shaft, a roller, and an actuator. In some examples, the outer shaft includes a lumen extending from a proximal end to a distal end. The inner shaft is disposed within the lumen. The roller rotatably is coupled with the distal end at an axis and configured to engage the fixation rod. The actuator operably couples with the inner shaft to translate the inner shaft within the lumen and cause rotation of the roller to impart linear movement on the fixation rod.

Abstract: A disposable cassette for detecting nucleic acids or performing other assays. The cassette can be inserted into a base station during use. The cassette has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The cassette also can have a gasket to ensure free air movement between open vent pockets. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with the vent pockets and the chambers.

Abstract: Provided herein is technology relating to collecting samples of soft matter compositions, and particularly, but not exclusively, to devices and methods for collecting stool samples.

Abstract: An instrument for attachment and insertion of a screw assembly into a surgical site includes a housing, an attachment shaft, and a drive shaft. The housing including a movable hub. The attachment shaft includes a proximal end for coupling to the housing and a distal end with a flexible portion for selectively attaching to a receiver of the screw assembly. The drive shaft within the attachment shaft includes a proximal end for selectively engaging the hub and a distal end with a driving feature for driving a head of the screw assembly.

Abstract: The instruments and methods of the present disclosure include an outer shaft, an inner shaft, a roller, and an actuator. In some examples, the outer shaft includes a lumen extending from a proximal end to a distal end. The inner shaft is disposed within the lumen. The roller rotatably is coupled with the distal end at an axis and configured to engage the fixation rod. The actuator operably couples with the inner shaft to translate the inner shaft within the lumen and cause rotation of the roller to impart linear movement on the fixation rod.

Abstract: An instrument for attachment and insertion of a screw assembly into a surgical site includes a housing, an attachment shaft, and a drive shaft. The housing including a movable hub. The attachment shaft includes a proximal end for coupling to the housing and a distal end with a flexible portion for selectively attaching to a receiver of the screw assembly. The drive shaft within the attachment shaft includes a proximal end for selectively engaging the hub and a distal end with a driving feature for driving a head of the screw assembly.

Abstract: Provided herein is technology relating to collecting samples of soft matter compositions, and particularly, but not exclusively, to devices and methods for collecting stool samples.

Abstract: A semi-rigid head for a bone screw comprising includes a first rigid portion, a second rigid portion, and a semi-rigid portion. The first rigid portion is configured to receive a fixation rod. The second rigid portion is configured for coupling with a bone screw. The semi-rigid portion links the first rigid portion with the second rigid portion.

Abstract: The present invention provides a sample collection device for determining that an adequate amount of sample is collected, the sample collection device including a sample collection member for collecting a fluid sample and at least one electrode, the at least one electrode being in liquid communication with the sample collection member and including a processor. In one embodiment, the sample collection member includes a groove structure, wherein at least one electrode is located on each side of the groove.