Abstract: To restore consistency of a digital twin database, identifiers with metadata imported from various data sources are processed by an encoder, which computes latent representations of the identifiers that are compared by an efficient similarity metric. If the respective similarity score exceeds a threshold, a match is detected between the identifiers. In that case, the digital twin database is updated by aligning the first identifier and the second identifier. This matching algorithm for equipment identifiers updates the digital twin data automatically and continuously by aligning identifiers which refer to the same piece of equipment. The updates flow directly into the digital twin database, thereby removing the manual effort. Using approximate nearest neighbor methods is highly efficient, especially for large plants. The encoder is implemented as an autoencoder which relies only on unlabeled training data.

Abstract: A system, method, and computer-readable medium are disclosed for labeling a component for component serialization. The component labeling is initiated, and a label is printed for the component. A collaborative robot or “cobot” retrieves the printed label and moves the label in place for attachment. Iterative views are performed until a tolerance value of the views is reached and the label is attached to the component. Information on the label and other labels are scanned and entered into an enterprise resource planning (ERP) system.

Abstract: A system, method, and computer-readable medium are disclosed for labeling a component for component serialization. The component labeling is initiated, and a label is printed for the component. A collaborative robot or “cobot” retrieves the printed label and moves the label in place for attachment. Iterative views are performed until a tolerance value of the views is reached and the label is attached to the component. Information on the label and other labels are scanned and entered into an enterprise resource planning (ERP) system.

Abstract: A series of heteroaryl-substituted quinoxaline and quinoline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions, said substituted derivatives having the general formula

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: A series of 5,5-dimethyl-5,6-dihydro-1,3-benzothiazol-7(4H)-one and 7,7-dimethyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-c]azepin-4-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted benzofused morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. Formula (I).

Abstract: Systems and methods for insuring that a client computer has up-to-date virus protection are provided, and include initiating a boot sequence pursuant to a boot image on a client computer for accessing a network, accessing a remote management server according to a preliminary instruction from the boot image, determining whether the client includes a latest virus file and forwarding the latest virus file if the client does not include the latest virus file.

Abstract: A series of heteroaryl-substituted quinoxaline and quinoline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: A series of 5,6-dihydro-1,3-benzothiazol-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PD kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: Systems and methods for insuring that a client computer has up-to-date virus protection are provided, and include initiating a boot sequence pursuant to a boot image on a client computer for accessing a network, accessing a remote management server according to a preliminary instruction from the boot image, determining whether the client includes a latest virus file and forwarding the latest virus file if the client does not include the latest virus file.

Abstract: Systems and methods for insuring that a client computer has up-to-date virus protection are provided, and include initiating a boot sequence pursuant to a boot image on a client computer for accessing a network, accessing a remote management server according to a preliminary instruction from the boot image, determining whether the client includes a latest virus file and forwarding the latest virus file if the client does not include the latest virus file.

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: A series of 5,5-dimethyl-5,6-dihydro-1,3-benzothiazol-7(4H)-one and 7,7-dimethyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-c]azepin-4-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted benzofused morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. Formula (I).

Abstract: A series of 5,6-dihydro-1,3-benzothiazol-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PD kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: Techniques for autonomous policy discovery are provided. Machines have personality profiles. The personality profiles permit machines to request advice from different machines having similar personality profiles. This facilitates automatic and autonomous discovery of policies for detected events and facilitates autonomous processing of actions, which are processed in response to the discovered policies. Furthermore, the personality profiles allow administrators to monitor and to dynamically alter policies associated with the machines.

Abstract: Quinolone derivatives of formula (1) are described: 1

Abstract: A compound of the formula wherein R1 is C1-3 alkyl optionally substituted with one or more fluorines; R2 is C1-6 alkyl, cycloalkyl or NR4R5; R3 is a pyrazole, imidazole or isoxazole group of partial formula (A), (B) or (C) NR4R5 is a nitrogen-containing heterocyclic ring; R6 is C1-3 alkyl; and R7 and R8, which are the same or different, each represents C1-3 alkyl, halogen, CF3 or CN; or a pharmaceutically-acceptable salt thereof.

Abstract: Compounds that are inhibitors of phosphodiesterase and have therapeutic utility, are of formula (i) wherein R1 is C3-6 cycoalkyl, or C1-3 alkyl optionally substituted with one or more fluorine atoms; R2 is C1-6 alkyl, C3-6 cycloalkyl, CF3, CH2CF3, C2F5 or NR4R5; R3 is a pyrazole, imidazole or isoxazole group of partial formula (A), (B) or (C) NR4R5 is a nitrogen-containing heterocyclic ring; R6 is C1-3 alkyl; and R7 and R8, which are the same or different, are each H, C1-3 alkyl, halogen, CF3 or CN, provided that both are not H; or a pharmaceutically-acceptable salt thereof

Abstract: 1-Alkyl-substituted-quinolone-3-carboxamides have therapeutic utility via inhibition of Phosphodiesterase IV esterase and/or Tumour Necrosis Factor activity. The compounds of the invention have the general formula (I): ##STR1## The compounds of the invention encompassed by formula (I) include enantiomers, diastereoisomers and mixtures, including racemic mixtures.

Abstract: 1-Alkyl-substituted-quinolone-3-carboxamides have therapeutic utility via inhibition of Phosphodiesterase IV esterase and/or Tumor Necrosis Factor activity.