Abstract: The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1) gene, the Factor XII (Hageman Factor (F12) gene, or the Kininogen 1 (KNG1) gene, and methods of using such RNAi agents to inhibit expression of a KLKB1 gene, an F12 gene, and/or a KNG1 gene, and methods of treating subjects having an hereditary angioedema (HAE) and/or a contact activation pathway-associated disorder.

Abstract: An optical assembly includes stacked planar lightwave circuit (PLC) members each having a plurality of waveguides in a respective plane, to provide optical connections to two-dimensional arrays of external optical waveguides (e.g., optical fiber cores), with one array including non-coplanar groups of waveguides having group members that are alternately arranged in a lateral direction. An optical assembly may provide optical connections between array of cores having a different pitch and/or orientation to serve as a fanout interface. Methods for fabricating an optical assembly are further provided.

Abstract: The present invention relates to a handpiece for spraying on a fluid jet with a handpiece casing in which a nozzle element for forming the jet geometry of the fluid jet is accommodated. The present invention is based on the object of specifying a handpiece for spraying on a fluid jet which can be produced in a more simple and inexpensive manner, and proposes to satisfy the object in that a nozzle element be fixedly connected to an integrally formed nozzle holder which sealingly abuts against the outer circumferential surface of the nozzle element and is fixed relative to the handpiece casing.

Abstract: A spraying device for spraying fluid from a replaceable refill is described, the refill comprising a refill body containing a reservoir of fluid to be sprayed, a valve stem in fluid communication with the reservoir and a spray head mounted on the valve stem, the spray head having a spray exit nozzle, wherein the spraying device comprises a housing with a releasably engagable top portion and base portion; wherein the base portion is configured to retain at least a lower portion of the refill body therein and wherein the top portion has a spray opening and holds an actuation mechanism, and wherein the top portion further comprises an alignment means for cooperation with the spray opening wherein alignment is provided to the refill spray head, in use, by a radially-spaced ledge substantially co-axial with the valve stem of the refill, the ledge being provided with an at least partially hollow core to receive at least a portion, in use, of the refill spray head, and wherein the ledge extends downwardly from the t

Abstract: A pump module with a casing having at least one pump piston is mounted in a reciprocatingly movable manner and may include a sealing element which, in pumping operation, abuts in a sealing manner against a cylinder. An embodiment of a pump module, which is easy to produce and can be disinfected or sterilized in a simple manner, includes a pump piston that can be fixated in a parking position in which the sealing element does not abut against the cylinder.

Abstract: An electrical nail polishing apparatus is described which comprises an electrical nail polishing device and a plurality of releasably connectable heads, wherein the electrical nail polishing device comprises: a main body housing accommodating a power source electrically connected to a motor with a rotating shaft connected to a transmission gearing mechanism connected to a proximal end of a drive shaft, the transmission gearing mechanism is configured to convert the rotational motion of the rotating shaft into oscillating longitudinal movement of the drive shaft, the remote end of the drive shaft extends beyond a tip end of the housing, the tip end of the housing is configured to extend away from the main body housing by at least 2 mm to provide a face surface with a flat side at or adjacent a diameter line of the main body housing with the ends of the flat side being joined by a curved side having one or more radii; and wherein the releasably connectable head comprises: a landing plate which has one side prov

Abstract: A pump module and a device for producing a fluid jet with a pump module are disclosed. In an embodiment the pump module may include a pump housing in which at least one pump piston is mounted in a reciprocatingly movable manner and is provided with at least one sealing element which during a pumping operation interacts with a cylinder. For creating such a pump module producible in a simple manner and nevertheless exhibiting the functionality necessary for the pumping operation, embodiments disclose a valve block, which receives at least one valve associated with the cylinder, wherein the cylinder is sealed against the valve block. Furthermore, a cover element may abut against the valve block on a side opposite to the cylinder and between itself and the valve block forms an inlet passage leading to the cylinder and/or an outlet passage communicating with the cylinder.

Abstract: A spraying device for spraying fluid from a replaceable refill is described wherein the refill possesses a refill body containing a reservoir of fluid to be sprayed, a valve stem in fluid communication with the reservoir and a spray head mounted on the valve stem, the spray head having an exit nozzle, wherein the spray device comprises: a housing formed from an top portion and a base portion which are releasably connectable with each other through contact between engagement means on each portion, wherein the top portion comprises: a cavity configured to house at least an top portion of the refill therein; a top surface and an engagement surface having an top portion housing wall therebetween, wherein the top portion housing wall has a thickness; an actuation mechanism configured, in use, to actuate the spray head to spray fluid via the exit nozzle; a spray opening configured to permit, in use, sprayed fluid to exit the device into the surrounding environment; and wherein the base portion comprises: a cavity c

Abstract: A spraying device for spraying fluid from a replaceable refill is described, the refill comprising a refill body containing a reservoir of fluid to be sprayed, a valve stem in fluid communication with the reservoir and a spray head mounted on the valve stem, the spray head having a spray exit nozzle, wherein the spraying device comprises a housing with a releasably engagable top portion and base portion; wherein the base portion is configured to retain at least a lower portion of the refill body therein and wherein the top portion has a spray opening and holds an actuation mechanism, and wherein the top portion further comprises an alignment means for cooperation with the spray opening wherein alignment is provided to the refill spray head, in use, by a radially-spaced ledge substantially co-axial with the valve stem of the refill, the ledge being provided with an at least partially hollow core to receive at least a portion, in use, of the refill spray head, and wherein the ledge extends downwardly from the t

Abstract: A spraying device for spraying fluid from a replaceable refill is described wherein the refill possesses a refill body containing a reservoir of fluid to be sprayed, a valve stem in fluid communication with the reservoir and a spray head mounted on the valve stem, the spray head having an exit nozzle, wherein the spray device comprises: a housing formed from an top portion and a base portion which are releasably connectable with each other through contact between engagement means on each portion, wherein the top portion comprises: a cavity configured to house at least an top portion of the refill therein; a top surface and an engagement surface having an top portion housing wall therebetween, wherein the top portion housing wall has a thickness; an actuation mechanism configured, in use, to actuate the spray head to spray fluid via the exit nozzle; a spray opening configured to permit, in use, sprayed fluid to exit the device into the surrounding environment; and wherein the base portion comprises: a ca

Abstract: The present invention relates to a handpiece for spraying on a fluid jet with a handpiece casing in which a nozzle element for forming the jet geometry of the fluid jet is accommodated. The present invention is based on the object of specifying a handpiece for spraying on a fluid jet which can be produced in a more simple and inexpensive manner, and proposes to satisfy the object in that a nozzle element be fixedly connected to an integrally formed nozzle holder which sealingly abuts against the outer circumferential surface of the nozzle element and is fixed relative to the handpiece casing.

Abstract: A device for producing a fluid jet suitable for hygienic requirements in mechanical wound cleaning, including removal of biological tissue, may include a drive casing with a drive and a pump module with a pump casing which can be detachably joined. The drive casing may include a positive-locking element and the pump casing may include a positive-locking counter-element. The positive-locking element may interact with the positive-locking counter-element so that the pump casing is imposed a pivotal motion relative to the drive casing until reaching a final position. In final position the pump casing may be connected to the drive casing and a drive element may be connected to an associated drive counter-element. Drive element and drive counter-element may be arranged eccentric to a pivot axis of the pivotal motion and may be formed so a positive-locking connection arises between the drive element and drive counter-element due to the pivotal motion.

Abstract: A pump module and a device for producing a fluid jet with a pump module are disclosed. In an embodiment the pump module may include a pump housing in which at least one pump piston is mounted in a reciprocatingly movable manner and is provided with at least one sealing element which during a pumping operation interacts with a cylinder. For creating such a pump module producible in a simple manner and nevertheless exhibiting the functionality necessary for the pumping operation, embodiments disclose a valve block, which receives at least one valve associated with the cylinder, wherein the cylinder is sealed against the valve block. Furthermore, a cover element may abut against the valve block on a side opposite to the cylinder and between itself and the valve block forms an inlet passage leading to the cylinder and/or an outlet passage communicating with the cylinder.

Abstract: A pump module with a casing having at least one pump piston is mounted in a reciprocatingly movable manner and may include a sealing element which, in pumping operation, abuts in a sealing manner against a cylinder. An embodiment of a pump module, which is easy to produce and can be disinfected or sterilized in a simple manner, includes a pump piston that can be fixated in a parking position in which the sealing element does not abut against the cylinder.

Abstract: The present invention describes a device for evaporating a volatile liquid from a container having a wick. The device includes a housing, a motion sensor, a first electrical heating element, and at least one of: a second electrical heating element; a fan; a region of increased heating capacity within the first electrical heating element. In use, the motion sensor is operable to detect motion in the vicinity of the device and, on detecting motion, the device operates to activate at least one of a second electrical heating element; a fan; a region of increased heating capacity within the first electrical heating element. The present invention also describes a method for evaporating the volatile liquid and a kit of parts for the same.

Abstract: A device for producing a fluid jet suitable for hygienic requirements in mechanical wound cleaning, including removal of biological tissue, may include a drive casing with a drive and a pump module with a pump casing which can be detachably joined. The drive casing may include a positive-locking element and the pump casing may include a positive-locking counter-element. The positive-locking element may interact with the positive-locking counter-element so that the pump casing is imposed a pivotal motion relative to the drive casing until reaching a final position. In final position the pump casing may be connected to the drive casing and a drive element may be connected to an associated drive counter-element. Drive element and drive counter-element may be arranged eccentric to a pivot axis of the pivotal motion and may be formed so a positive-locking connection arises between the drive element and drive counter-element due to the pivotal motion.