Abstract: Mutant Myxoma viruses are provided herein and methods of using these viruses to treat cancer or elicit an interferon response in a subject are also provided. The mutant Myxoma virus is modified to reduce or eliminate the activity or expression of Myxoma virus protein M62 as compared to a control virus. The mutant virus is capable of stimulating an interferon response in subjects after administration and can also lead to inhibition, reduction or elimination of the CD14+ tumor associated macrophage inhibition of CD4+ T cells in a subject having cancer and lead to a change in the tumor microenvironment to treat the cancer or work in combination with other cancer therapeutics to treat the cancer as described herein.

Abstract: Mutant Myxoma viruses are provided herein and methods of using these viruses to treat cancer or elicit an interferon response in a subject are also provided. The mutant Myxoma virus is modified to reduce or eliminate the activity or expression of Myxoma virus protein M62 as compared to a control virus. The mutant virus is capable of stimulating an interferon response in subjects after administration and can also lead to inhibition, reduction or elimination of the CD14+ tumor associated macrophage inhibition of CD4+ T cells in a subject having cancer and lead to a change in the tumor microenvironment to treat the cancer or work in combination with other cancer therapeutics to treat the cancer as described herein.

Abstract: A method of manufacture of an insulated structural panel which includes the step of feeding and laminating of a pair of outer skins (13, 14) and a core of insulating material (8) interposed therebetween through a press bed (7) to facilitate adhesion of an adhesive to internal surfaces of each outer skin (13, 14) and thus facilitate bonding of the core of insulating material (8) to each adjacent internal surface of each outer skin (13, 14) wherein each outer skin (13, 14) has an outer surface which is gripped by a conveyor (26, 27) having a continuous working surface in contact with each of said outer surfaces (13, 14) characterised in that said continuous working surface is formed by a coating (40, 40A, 40B) of elastomer or other synthetic polymer applied to a metal substrate. There is also provided a laminating machine (10) for use in the method as well as a track plate (37) for use in the laminating machine (10).