Patents by Inventor Martin Chandler
Martin Chandler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12161811Abstract: An HME has a housing (10) moulded in two parts (26 and 27) of a thick, thermally-insulative foamed plastics to form an enlarged central region (13) and opposite end walls (24 and 25). Separate patient and machine end couplings (11 and 12) are bonded to openings (37 and 47) in the end walls. The two housing parts (26 and 27) are bonded end to end about an HME element (14) formed by a strip of treated corrugated paper wound about a support sleeve (50).Type: GrantFiled: May 15, 2017Date of Patent: December 10, 2024Assignee: ICU MEDICAL INTERNATIONAL LIMITEDInventor: Martin Chandler
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Patent number: 12098406Abstract: This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis. Also provided herein are formulations for stable, freeze dried bacterial extracts that when stored at room temperature retain at least about 70% protein synthesis activity compared to undried frozen bacterial extracts.Type: GrantFiled: June 29, 2022Date of Patent: September 24, 2024Assignee: Sutro Biopharma, Inc.Inventors: Martin Chandler, Kirk Hayenga, Henry Heinsohn
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Publication number: 20230167475Abstract: This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis. Also provided herein are formulations for stable, freeze dried bacterial extracts that when stored at room temperature retain at least about 70% protein synthesis activity compared to undried frozen bacterial extracts.Type: ApplicationFiled: June 29, 2022Publication date: June 1, 2023Inventors: Martin Chandler, Kirk Hayenga, Henry Heinsohn
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Patent number: 11408021Abstract: This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis. Also provided herein are formulations for stable, freeze dried bacterial extracts that when stored at room temperature retain at least about 70% protein synthesis activity compared to undried frozen bacterial extracts.Type: GrantFiled: April 6, 2020Date of Patent: August 9, 2022Assignee: Sutro Biopharma, Inc.Inventors: Martin Chandler, Kirk Hayenga, Henry Heinsohn
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Publication number: 20200299745Abstract: This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis. Also provided herein are formulations for stable, freeze dried bacterial extracts that when stored at room temperature retain at least about 70% protein synthesis activity compared to undried frozen bacterial extracts.Type: ApplicationFiled: April 6, 2020Publication date: September 24, 2020Inventors: Martin Chandler, Kirk Hayenga, Henry Heinsohn
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Patent number: 10648010Abstract: This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis. Also provided herein are formulations for stable, freeze dried bacterial extracts that when stored at room temperature retain at least about 70% protein synthesis activity compared to undried frozen bacterial extracts.Type: GrantFiled: January 8, 2016Date of Patent: May 12, 2020Assignee: SUTRO BIOPHARMA, INC.Inventors: Martin Chandler, Kirk Hayenga, Henry Heinsohn
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Patent number: 10562951Abstract: The use of two tandem microfiltration (MF) steps in a process for making recombinant insulin is described. The two MF steps in a single downstream purification unit operation reduce both soluble and insoluble impurities and exchange the insulin product into a suitable buffer for downstream purification.Type: GrantFiled: March 3, 2016Date of Patent: February 18, 2020Assignee: Merck Sharp & Dohme Corp.Inventors: Sean S. Gant, Michael J. Iammarino, Kristi Kerchner, Michael A. Rauscher, David J. Roush, Christopher H. Smith, Martin Chandler, Matthew Petroff
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Publication number: 20190275282Abstract: An HME has a housing (10) moulded in two parts (26 and 27) of a thick, thermally-insulative foamed plastics to form an enlarged central region (13) and opposite end walls (24 and 25). Separate patient and machine end couplings (11 and 12) are bonded to openings (37 and 47) in the end walls. The two housing parts (26 and 27) are bonded end to end about an HME element (14) formed by a strip of treated corrugated paper wound about a support sleeve (50).Type: ApplicationFiled: May 15, 2017Publication date: September 12, 2019Applicant: SMITHS MEDICAL INTERNATIONAL LIMITEDInventor: Martin Chandler
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Publication number: 20180044395Abstract: The use of two tandem microfiltration (MF) steps in a process for making recombinant insulin is described. The two MF steps in a single downstream purification unit operation reduce both soluble and insoluble impurities and exchange the insulin product into a suitable buffer for downstream purification.Type: ApplicationFiled: March 3, 2016Publication date: February 15, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Sean S. Gant, Michael J. Iammarino, Kristi Kerchner, Michael A. Rauscher, David J. Roush, Christopher H. Smith, Martin Chandler, Matthew Petroff
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Publication number: 20180002732Abstract: This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis. Also provided herein are formulations for stable, freeze dried bacterial extracts that when stored at room temperature retain at least about 70% protein synthesis activity compared to undried frozen bacterial extracts.Type: ApplicationFiled: January 8, 2016Publication date: January 4, 2018Inventors: Martin Chandler, Kirk Hayenga, Henry Heinsohn
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Patent number: 6755152Abstract: There is provided an apparatus and method for monitoring pulsation of a milking system in a dairy facility. The milking system includes vacuum hoses that extend from a vacuum source to a milking claw. The pressure in each vacuum hose is changed by a pulsator, with the vacuum hoses being out of phase with one another. The pressure sensors are coupled to the respective vacuum hoses, which sensors monitor the pressure pulsations to ensure that the pulsator is operating satisfactorily. The pressure sensors are coupled to the vacuum hoses by way of passageways or hoses. A bypass is provided between the passageways so as to provide air circulation in the otherwise dead air space in these passageways. The bypass is small so as to not interfere with the pressure measurements by the sensors and is located in close proximity to the pressure sensors so as to minimize the amount of dead air space.Type: GrantFiled: May 22, 2003Date of Patent: June 29, 2004Assignee: Senseability, Inc.Inventor: Martin Chandler Cooper
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Patent number: 6553934Abstract: A pulsator provides alternating vacuum pressure and atmospheric pressure to an elastomeric liner in a sleeve of a milking claw in a dairy barn. The purpose of pulsation is to alternate the cow teat between a milking phase and a rest phase. The invention monitors the operation of the pulsator to determine if the pulsator is operating satisfactorily. The invention records data during a calibration mode from the pulsator in normal operation. The data that is recorded is the duration of the milking phase and the rest phase and the associated pressures. During pulsator operation, the invention measures the pulsation between atmospheric and vacuum pressures provided to the milking claw and compares this measured data to the recorded calibration data. If the pulsator is not found to be operating within predetermined tolerances, then an indication of a pulsator malfunction is provided, typically in the form of a light located in the milking pen.Type: GrantFiled: January 3, 2001Date of Patent: April 29, 2003Assignee: Senseability, Inc.Inventors: Jeffrey W. Gentner, Martin Chandler Cooper
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Publication number: 20020104484Abstract: A pulsator provides alternating vacuum pressure and atmospheric pressure to an elastomeric liner in a sleeve of a milking claw in a dairy barn. The purpose of pulsation is to alternate the cow teat between a milking phase and a rest phase. The invention monitors the operation of the pulsator to determine if the pulsator is operating satisfactorily. The invention records data during a calibration mode from the pulsator in normal operation. The data that is recorded is the duration of the milking phase and the rest phase and the associated pressures. During pulsator operation, the invention measures the pulsation between atmospheric and vacuum pressures provided to the milking claw and compares this measured data to the recorded calibration data. If the pulsator is not found to be operating within predetermined tolerances, then an indication of a pulsator malfunction is provided, typically in the form of a light located in the milking pen.Type: ApplicationFiled: January 3, 2001Publication date: August 8, 2002Inventors: Jeffrey W. Gentner, Martin Chandler Cooper