Abstract: Methods for determining molecular concentration using solid-state nanopores are provided. The methods include measuring a current signal and using the signal to identify first and second electrical signatures. A first set is used to determine a first rate of a target having an unknown concentration, and a second set is used to determine a second rate of a control having a known concentration. The first and second rates are each a function of a pore property factor that represents physical properties of the solid-state nanopore and operating conditions. The first rate is further a function of a first property factor that represents physical properties of the target and the unknown concentration. The second rate is further a function of a second property factor that represents physical properties of the control and the known concentration. Ratios of the first rate to the second rate are used to determine the unknown concentration.

Abstract: An imaging system for acquiring multi-dimensional tomographic image data of an object, the imaging system having (1) a plurality of detectors to acquire image data, the detectors coupled to a supporting structure, wherein at least one of the detectors is adapted to move relative to the object during image data acquisition and wherein the detectors are adapted to rotate independently of each other, provided that image data from the detectors are collected concomitantly during a study time and (2) a data analyzer adapted to acquire and/or reconstruct the image data.

Abstract: An imaging system for acquiring multi-dimensional tomographic image data of an object, the imaging system having (1) a plurality of detectors to acquire image data, the detectors coupled to a supporting structure, wherein at least one of the detectors is adapted to move relative to the object during image data acquisition and wherein the detectors are adapted to rotate independently of each other, provided that image data from the detectors are collected concomitantly during a study time and (2) a data analyzer adapted to acquire and/or reconstruct the image data.