Abstract: In one aspect, a drug delivery device is provided herein including: a monolithic body having a plurality of fluid ducts and at least one outlet duct formed therein; a plurality of drug cartridges attached to the body, the drug cartridges each including a reservoir for accommodating at least one drug wherein, the plurality of fluid ducts is arranged to convey the drugs from the drug cartridges to the at least one outlet duct; and, a needle support spaced from the body, the needle support including a needle configured for insertion into a patient for drug delivery, the needle support including adhesive for releasable securement to a patient, wherein, the needle support is connected to the body by a flexible tether through which passes at least one fluid passageway formed to convey drug from the at least one outlet duct to the needle.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: A vehicle cooling arrangement includes a first electric machine with a drive output shaft and a first rotor mounted to rotate about a rotation axis and extending axially around the rotation axis. A first stator surrounds the first rotor peripherally. A second electric machine is mounted axially close to the first electric machine and has a second rotor mounted to rotate about the rotation axis and the drive output shaft. A second stator surrounds the second rotor peripherally. A common housing forms a casing for the first and second electric machines and the drive output shaft extends axially through the housing. The first and second electric machines form a coolant circuit having at least one coolant line arranged to cool the first and second rotors and a second coolant line parallel to the first coolant line and arranged to separately cool the first and second stators.

Abstract: A computer-implemented method and a corresponding system for planning the behavior of a vehicle using a predefined set of rules with prioritized rules for assessing possible behaviors of the vehicle in a given situation. For this purpose, situation-specific information is aggregated, and an environmental model of the given situation is generated based on the aggregated situation-specific information. The set of rules includes a decision-making process structure, which represents the prioritization of the individual rules of the set of rules. On the basis of the environmental mode, boundary conditions for the possible behaviors of the vehicle are determined. The latter are then prioritized by applying the decision-making process structure to the respective boundary conditions.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: In one aspect, a method is provided herein of preparing a drug delivery device, the drug delivery device having a body with at least one fluid duct being open along a first face of the body, the at least one fluid duct for conveying drug from at least one reservoir to a needle configured for injection into a patient, the method including: providing a barrier across the first face of the body to at least cover the at least one fluid duct, wherein the barrier is ultraviolet transmissive; and, exposing the first face of the body to ultraviolet radiation so as to allow the ultraviolet radiation to pass through the barrier and decontaminate the at least one fluid duct.

Abstract: Aspects of the disclosure relate to a template driven interface system having a parsing engine that may dynamically render web forms given a specification document. In some instances, the architecture may leverage the specification document and enable creation, management, and eventual decommissioning actions. The architecture may be framework-agnostic, allowing for adaptive and agile development of end user interfaces for services developed by different entities or product providers. The different entities may be external entities having control over their assets and related asset schemas. The architecture may allow for real-time updates as compared to scheduled release cycles.

Abstract: Aspects of the disclosure relate to a template driven interface system having a parsing engine that may dynamically render web forms given a specification document. In some instances, the architecture may leverage the specification document and enable creation, management, and eventual decommissioning actions. The architecture may be framework-agnostic, allowing for adaptive and agile development of end user interfaces for services developed by different entities or product providers. The different entities may be external entities having control over their assets and related asset schemas. The architecture may allow for real-time updates as compared to scheduled release cycles.

Abstract: The invention relates to a cooling arrangement (1, 1a) for cooling a stator (2) of an electric machine having a housing (10) and a stator (2), which is arranged fixed about a rotation axis in the housing (10), where the rotation axis defines an axial direction and a radial direction radially relative to the rotation axis. At the respective axial ends of the stator (2) a first cooling fluid ring (8, 8a) is mounted to form a first ring-shaped annular space with the housing (10) and a second cooling fluid ring (9) is mounted to form a second ring-shaped annular space, each of them designed to convey cooling fluid.

Abstract: Device for articulation of two timepiece components (10, 20) including first and second timepiece components connected to one another in an articulated manner using at least one articulation pin (1), wherein the two timepiece components each include first and second guide surfaces that cooperate with first and second articulation surfaces (1a, 1e) respectively of at least one articulation portion of the at least one articulation pin (1), the guide surfaces and the respective articulation surfaces being positioned face-to-face to guide by rubbing the movement in rotation of the respective timepiece components (10, 20) relative to the at least one articulation pin (1), the at least one articulation portion of the articulation pin (1) or the at least one articulation pin (1) being made entirely of ceramic, the at least one articulation pin (1) including at least one portion of lower strength positioned out of reach of the guide surfaces of the respective timepiece components, and the at least one articulation po

Abstract: A rotor (1) for an electric machine (25) which comprises a rotor support (2). The rotor support has cylindrical inner and outer shells (3, 4). A magnetic flux-carrying rotor component has first and second end faces (6, 7) and carries the cylindrical outer shell (4). A rotationally shaft section (8) is arranged in an inside space (9) of the rotor support and mounted coaxially with the rotor support. At least in the area of the first end face (6) the outer shell has first teeth which face toward the magnetic flux-carrying rotor component and a first tooth base between respective pairs of first teeth, and at least in the area of the second end face (7) the outer shell (4) has second teeth which face toward the magnetic flux-carrying rotor component and a second tooth base between respective pairs of second teeth. The invention also relates to an electric machine.

Abstract: A consumption meter, e.g. a water or heat meter, for measuring a flow rate of a fluid supplied in a flow tube. First and second ultrasonic transducers are arranged at the flow tube for transmitting and receiving ultrasonic signals transmitted through the fluid and operated by a flow measurement sub-circuit for generating a signal indicative of the flow rate of the fluid. A noise measurement sub-circuit operates a sensor arranged at the flow tube for detection of acoustic signals of the flow tube, and being arranged to generate a signal indicative of a noise level of the flow tube accordingly. This sensor may comprise a separate transducer, or the sensor may be constituted by one or both of the first and second ultrasonic transducers. The consumption meter may communicate data representative of the noise level via a communication module along with data consumed amount of water, heat etc.

Abstract: Methods of assessing the pathological and/or physiological state of a subject, methods of monitoring a subject with heart failure or a subject that has been diagnosed as having or being at risk of having a condition associated with dyspnea and/or fatigue, and methods of diagnosing a subject as having decompensated heart failure are provided. The methods comprise obtaining a voice recording from a word-reading test from the subject, wherein the voice recording is from a word-reading test comprising reading a sequence of words drawn from a set of n words and analysing the voice recording, or a portion thereof.

Abstract: A consumption meter, e.g. a water or heat meter, for measuring a flow rate of a fluid supplied in a flow tube. First and second ultrasonic transducers are arranged at the flow tube for transmitting and receiving ultrasonic signals transmitted through the fluid and operated by a flow measurement sub-circuit for generating a signal indicative of the flow rate of the fluid. A noise measurement sub-circuit operates a sensor arranged at the flow tube for detection of acoustic signals of the flow tube, and being arranged to generate a signal indicative of a noise level of the flow tube accordingly. This sensor may comprise a separate transducer, or the sensor may be constituted by one or both of the first and second ultrasonic transducers. The consumption meter may communicate data representative of the noise level via a communication module along with data consumed amount of water, heat etc.

Abstract: Systems and methods are provided for predicting metastasis of a cancer in a subject. A plurality of data elements for the subject's cancer is obtained, including sequence features comprising relative abundance values for gene expression in a cancer biopsy of the subject, optional personal characteristics about the subject, and optional clinical features related to the stage, histopathological grade, diagnosis, symptom, comorbidity, and/or treatment of the cancer in the subject, and/or a temporal element associated therewith. One or more models are applied to the plurality of data elements, determining one or more indications of whether the cancer will metastasize. A clinical report comprising the one or more indications is generated.

Abstract: A system and method are provided for training and using a machine learning model to analyze hematoxylin and eosin (H&E) slide images, where the machine learning model is trained using a training data set comprising a plurality of unmarked H&E images and a plurality of marked H&E images, each marked H&E image being associated with one unmarked H&E image and each marked H&E image including a location of one or more molecules determined by analyzing a multiplex IHC image having at least two IHC stains, each IHC stain having a unique color and a unique target molecule. Predicted molecules and locations identified with the machine learning model result in an immunotherapy response class being assigned to the H&E slide image.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for processing fundus images using fundus image processing machine learning models. One of the methods includes obtaining a model input comprising one or more fundus images, each fundus image being an image of a fundus of an eye of a patient; processing the model input using a fundus image processing machine learning model, wherein the fundus image processing machine learning model is configured to process the model input comprising the one or more fundus image to generate a model output; and processing the model output to generate health analysis data.

Abstract: A system and method are provided for training and using a machine learning model to analyze hematoxylin and eosin (H&E) slide images, where the machine learning model is trained using a training data set comprising a plurality of unmarked H&E images and a plurality of marked H&E images, each marked H&E image being associated with one unmarked H&E image and each marked H&E image including a location of one or more molecules determined by analyzing a multiplex IHC image having at least two IHC stains, each IHC stain having a unique color and a unique target molecule. Predicted molecules and locations identified with the machine learning model result in an immunotherapy response class being assigned to the H&E slide image.