Patents by Inventor Martin Citron

Martin Citron has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for determining whether a compound alters the amount of at least one ?? (X-41) peptide and the amount of either total ?? or at least one ?? (X-40) peptide produced by a non-human mammal
    Patent number: 7993627
    Abstract: This invention provides methods of screening compounds for their ability to alter the production of A?(x?41) alone or in combination with A?(x?40). The methods involve administering compounds to cells, specifically measuring the amounts of A?(x?40) and A?(x?41) produced by the cells, and comparing these amounts to that produced by the cells without administration of the compounds.
    Type: Grant
    Filed: December 30, 2002
    Date of Patent: August 9, 2011
    Assignees: Elan Pharmaceuticals, Inc., Brigham and Women's Hospital
    Inventors: Martin Citron, Dennis J. Selkoe, Peter A. Seubert, Dale B. Schenk
  • Beta secretase genes
    Patent number: 7582465
    Abstract: Disclosed are novel genes encoding beta secretase polypeptides. Also disclosed are methods of making and using the polypeptides.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: September 1, 2009
    Assignee: Amgen Inc.
    Inventors: Martin Citron, Robert James Vassar, Brian Drake Bennett
  • Beta secretase polypeptides
    Patent number: 7579180
    Abstract: Disclosed are novel genes encoding beta secretase polypeptides. Also disclosed are methods of making and using the polypeptides.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: August 25, 2009
    Assignee: Amgen Inc.
    Inventors: Martin Citron, Robert James Vassar, Brian Drake Bennett
  • Beta Secretase Genes
    Publication number: 20070191298
    Abstract: Disclosed are novel genes encoding beta secretase polypeptides. Also disclosed are methods of making and using the polypeptides.
    Type: Application
    Filed: February 28, 2007
    Publication date: August 16, 2007
    Applicant: AMGEN INC.
    Inventors: Martin Citron, Robert Vassar, Brian Bennett
  • Beta Secretase Polypeptides
    Publication number: 20070173477
    Abstract: Disclosed are novel genes encoding beta secretase polypeptides. Also disclosed are methods of making and using the polypeptides.
    Type: Application
    Filed: February 28, 2007
    Publication date: July 26, 2007
    Applicant: AMGEN INC.
    Inventors: Martin Citron, Robert Vassar, Brian Bennett
  • Screening compounds for the ability to alter the production of amyloid-&bgr; peptide
    Patent number: 6610493
    Abstract: This invention provides methods of screening compounds for their ability to alter the production of A&bgr;(x≧41) alone or in combination with A&bgr;(x≦40). The methods involve administering compounds to cells, specifically measuring the amounts of A&bgr;(x≦40) and A&bgr;(x≧41) produced by the cells, and comparing these amounts to that produced by the cells without administration of the compounds.
    Type: Grant
    Filed: June 18, 1996
    Date of Patent: August 26, 2003
    Assignees: Brigham and Women's Hospital, Athena Neurosciences, Inc.
    Inventors: Martin Citron, Dennis J. Selkoe, Peter A. Seubert, Dale Schenk
  • Screening compounds for the ability to alter the production of amyloid-beta peptide (x-41)
    Publication number: 20030148392
    Abstract: This invention provides methods of screening compounds for their ability to alter the production of A&bgr;(x≧41) alone or in combination with A&bgr;(x≦40). The methods involve administering compounds to cells, specifically measuring the amounts of A&bgr;(x≦40) and A&bgr;(x≧41) produced by the cells, and comparing these amounts to that produced by the cells without administration of the compounds.
    Type: Application
    Filed: December 30, 2002
    Publication date: August 7, 2003
    Applicant: Athena Neurosciences, Inc. a Delaware corporation
    Inventors: Martin Citron, Dennis J. Selkoe, Peter A. Seubert, Dale B. Schenk
  • Alpha-synuclein super-mutants accelerate alpha-synuclein aggregation
    Publication number: 20020152480
    Abstract: Parkinson's disease (PD) is a neurodegenerative disorder which is pathologically characterized by the presence of intracytoplasmic Lewy bodies, the major component of which are filaments consisting of &agr;-synuclein. The present invention provides &agr;-synuclein mutations which accelerate &agr;-synuclein aggregation and can thus be utilized for transgenic animal production and generation of the first progressive PD model. Also provided is an in vitro aggregation assay which can be utilized to identify &agr;-synuclein nucleation inhibitors for the treatment of PD.
    Type: Application
    Filed: January 4, 2002
    Publication date: October 17, 2002
    Applicant: Amgen Inc.
    Inventors: Anja Leona Biere, Martin Citron
  • &agr;-synuclein super-mutants accelerate &agr;-synuclein aggregation
    Patent number: 6184351
    Abstract: Parkinson's disease (PD) is a neurodegenerative disorder which is pathologically characterized by the presence of intracytoplasmic Lewy bodies, the major component of which are filaments consisting of &agr;-synuclein. The present invention provides &agr;-synuclein mutations which accelerate &agr;-synuclein aggregation and can thus be utilized for transgenic animal production and generation of the first progressive PD model. Also provided is an in vitro aggregation assay which can be utilized to identify &agr;-synuclein nucleation inhibitors for the treatment of PD.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: February 6, 2001
    Assignee: Amgen Inc.
    Inventors: Anja Leona Biere, Martin Citron