Abstract: An aerosol provision system comprising a reservoir for aerosolizable material, a wick for receiving aerosolizable material from the reservoir, and a vaporizer for vaporizing aerosolizable material in the wick. A structure from the aerosol provision system, in response to a temperature of the vaporizer or wick exceeding a predetermined temperature, is operable to change from a first configuration in which operation of the vaporizer is possible, to a second configuration in which operation of the vaporizer is prevented. This structure could be operable to reversibly change between the first configuration and the second configuration, and might be configured to short circuit the vaporizer in some cases. The structure might also be configured to disconnect a connection lead for delivering power to the in some cases.

Abstract: A control circuit for a vapor provision system includes comprises a first controller with capability to control a first set of components in the vapor provision system; a second controller with capability to control a second set of components in the vapor provision system, at least one component in the second set being also in the first set; and a communication link between the first controller and the second controller by which at least one controller can monitor operation of the other controller; wherein one or both controllers is operable to, via the communication link, detect a fault with the capability of the other controller to control the at least one component and, in response, assume control of the at least one component.

Abstract: A control circuit for a vapor provision system includes comprises a first controller with capability to control a first set of components in the vapor provision system; a second controller with capability to control a second set of components in the vapor provision system, at least one component in the second set being also in the first set; and a communication link between the first controller and the second controller by which at least one controller can monitor operation of the other controller; wherein one or both controllers is operable to, via the communication link, detect a fault with the capability of the other controller to control the at least one component and, in response, assume control of the at least one component.

Abstract: An electronic vapor provision system including: a vaporizer for vaporizing aerosol precursor material for inhalation by a user of the electronic vapor provision system; a power supply for supplying power to the vaporizer; a wall defining an air flow path along which air travels through the electronic vapor provision system when a user inhales or exhales on the electronic vapor provision system; a temperature sensor mounted in the air flow path adjacent a portion of the wall of the air flow path; and a controller configured to cause power to be supplied to the temperature sensor to heat the temperature sensor and to cause power to be supplied to the vaporizer to vaporize the aerosol precursor material in response to detecting a change in temperature of the temperature sensor; wherein the air flow path is arranged such that, during inhalation or exhalation by the user, air travelling along the air flow path is directed at the temperature sensor in a direction that is towards the portion of the wall adjacent to

Abstract: There is provided an aerosol delivery device including a power source and controller, the controller being configured to control delivery of power from the power source to an aerosol-generator during a single aerosol-generation event according to a first power delivery profile and a subsequent power delivery profile having a different profile to the first power delivery profile, wherein the first power delivery profile has a predetermined output based on the voltage of the power supply.

Abstract: An aerosol provision system comprising a reservoir for aerosolisable material; a wick configured to receive the aerosolizable material from the reservoir, a vaporizer configured to vaporize the aerosolizable material received in the wick, wherein the aerosol provision system is configured to measure at least one parameter of the wick to determine a status of the wick The parameter may be the moisture content of the wick, at least one physical dimension of the wick, and/or an optical parameter, such as the color of an external surface of the wick, or the reflectivity of an external surface of the wick.

Abstract: There is provided a connector configured to be retrofitted to an electronic aerosol provision system including a first connecting interface connectable to a vaporizer for vaporizing liquid for inhalation by a user; a second connecting interface connectable to a power supply for supplying power to the vaporizer; a sensor for sensing a parameter indicative of a change in the electronic aerosol provision system; and a control unit connected to the sensor and configured to output a signal based on the information from the sensor, wherein the connector, when connected to a vaporizer and to a power supply, forms an electronic aerosol provision system.

Abstract: The invention relates to the fields of biomaterials, tissue engineering and regenerative medicine. More specifically, it relates to biomaterial substrates having precise surface properties and the use thereof to investigate cell-material interactions. Provided is a cell culture system having a biomaterial substrate which has at least a first linear surface gradient oriented orthogonally to a second linear surface gradient, wherein the first gradient and the second gradient are selected from the group consisting of stiffness (S), (aligned) topography (T) and wettability (W). Also provided is a cell screening platform having a combination of at least two, preferably at least three, more preferably four distinct cell culture systems.

Abstract: A control circuit for a vapor provision system includes comprises a first controller with capability to control a first set of components in the vapor provision system; a second controller with capability to control a second set of components in the vapor provision system, at least one component in the second set being also in the first set; and a communication link between the first controller and the second controller by which at least one controller can monitor operation of the other controller; wherein one or both controllers is operable to, via the communication link, detect a fault with the capability of the other controller to control the at least one component and, in response, assume control of the at least one component.

Abstract: A control circuit for a vapor provision system includes comprises a first controller with capability to control a first set of components in the vapor provision system; a second controller with capability to control a second set of components in the vapor provision system, at least one component in the second set being also in the first set; and a communication link between the first controller and the second controller by which at least one controller can monitor operation of the other controller; wherein one or both controllers is operable to, via the communication link, detect a fault with the capability of the other controller to control the at least one component and, in response, assume control of the at least one component.

Abstract: A control circuit for a vapor provision system includes comprises a first controller with capability to control a first set of components in the vapor provision system; a second controller with capability to control a second set of components in the vapor provision system, at least one component in the second set being also in the first set; and a communication link between the first controller and the second controller by which at least one controller can monitor operation of the other controller; wherein one or both controllers is operable to, via the communication link, detect a fault with the capability of the other controller to control the at least one component and, in response, assume control of the at least one component.

Abstract: A control circuit for a vapor provision system includes a first controller with capability to control a first set of components in the vapor provision system; a second controller with capability to control a second set of components in the vapor provision system, at least one component in the second set being also in the first set; and a communication link between the first controller and the second controller by which at least one controller can monitor operation of the other controller; wherein one or both controllers is operable to, via the communication link, detect a fault with the capability of the other controller to control the at least one component and, in response, assume control of the at least one component.

Abstract: An electronic vapor provision system including: a vaporizer for vaporizing aerosol precursor material for inhalation by a user of the electronic vapor provision system; a power supply for supplying power to the vaporizer; a wall defining an air flow path along which air travels through the electronic vapor provision system when a user inhales or exhales on the electronic vapor provision system; a temperature sensor mounted in the air flow path adjacent a portion of the wall of the air flow path; and a controller configured to cause power to be supplied to the temperature sensor to heat the temperature sensor and to cause power to be supplied to the vaporizer to vaporize the aerosol precursor material in response to detecting a change in temperature of the temperature sensor; wherein the air flow path is arranged such that, during inhalation or exhalation by the user, air travelling along the air flow path is directed at the temperature sensor in a direction that is towards the portion of the wall adjacent to

Abstract: The invention relates to the fields of biomaterials, tissue engineering and regenerative medicine. More specifically, it relates to biomaterial substrates having precise surface properties and the use thereof to investigate cell-material interactions. Provided is a cell culture system having a biomaterial substrate which has at least a first linear surface gradient oriented orthogonally to a second linear surface gradient, wherein the first gradient and the second gradient are selected from the group consisting of stiffness (S), (aligned) topography (T) and wettability (W). Also provided is a cell screening platform having a combination of at least two, preferably at least three, more preferably four distinct cell culture systems.

Abstract: There is provided a connector configured to be retrofitted to an electronic aerosol provision system including a first connecting interface connectable to a vaporizer for vaporizing liquid for inhalation by a user; a second connecting interface connectable to a power supply for supplying power to the vaporizer; a sensor for sensing a parameter indicative of a change in the electronic aerosol provision system; and a control unit connected to the sensor and configured to output a signal based on the information from the sensor, wherein the connector, when connected to a vaporizer and to a power supply, forms an electronic aerosol provision system.

Abstract: A control circuit for a vapor provision system includes a first controller with capability to control a first set of components in the vapor provision system; a second controller with capability to control a second set of components in the vapor provision system, at least one component in the second set being also in the first set; and a communication link between the first controller and the second controller by which at least one controller can monitor operation of the other controller; wherein one or both controllers is operable to, via the communication link, detect a fault with the capability of the other controller to control the at least one component and, in response, assume control of the at least one component.

Abstract: A chain drive unit (4, 5, 6) for reducing chain vibrations comprising a chain wheel unit (43) with at least two sprockets (431, 432) that are arranged parallel on a common rotation axle, at least two parallel chains (51, 52) engaging these sprockets (431, 432). At least one damping element (6) connecting two adjoining chains (51, 52). The circumferential orientation of two adjoining sprockets (431, 432) differs by a partial pitch (pP) and the damping element (6) comprises a first fixation (61) on its one free end for the lateral fixation to the first chain (51), a second fixation (62) on its opposite free end for the lateral fixation to the second chain (52) and a force transmission unit (63, 8, 9) arranged between the first and the second fixation transmitting an applied force from the first fixation (61) to the second fixation (62) and vice versa.

Abstract: A chain drive unit (4, 5, 6) for reducing chain vibrations comprising a chain wheel unit (43) with at least two sprockets (431, 432) that are arranged parallel on a common rotation axle, at least two parallel chains (51, 52) engaging these sprockets (431, 432). At least one damping element (6) connecting two adjoining chains (51, 52). The circumferential orientation of two adjoining sprockets (431, 432) differs by a partial pitch (pP) and the damping element (6) comprises a first fixation (61) on its one free end for the lateral fixation to the first chain (51), a second fixation (62) on its opposite free end for the lateral fixation to the second chain (52) and a force transmission unit (63, 8, 9) arranged between the first and the second fixation transmitting an applied force from the first fixation (61) to the second fixation (62) and vice versa.

Abstract: A crosslinked gelatin hydrogel composition for tissue augmentation.

Abstract: The invention relates to the field of cancer therapy and diagnosis, in particular of carcinomas. The invention provides an isolated and/or recombinant nucleic acid comprising a tissue specific promoter or functional fragment thereof allowing for expression of a nucleic acid of interest operably linked to said promoter or functional fragment thereof in a cancer cell wherein said expression in said cancer cell is essentially carcinoma selective.