Patent number: 6875570
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Grant
Filed:
September 26, 2001
Date of Patent:
April 5, 2005
Assignee:
CuraGen Corporation
Inventors:
Valerie L. Gerlach, John R. MacDougall, Glennda Smithson, Isabelle Millet, David Stone, Erik Gunther, Karen Ellerman, William M. Grosse, John P. Alsobrook, II, Denise M. Lepley, Catherine E. Burgess, Muralidhara Padigaru, Ramesh Kekuda, Kimberly A. Spytek, Martin D. Leach, Richard A. Shimkets
Publication number: 20040048256
Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
September 6, 2002
Publication date:
March 11, 2004
Inventors:
Michele L. Agee, John P. Alsobrook, David W. Anderson, Constance Berghs, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Elina Catterton, John S. Chant, Amitabha Chaudhuri, Julie Bokor, Vincent A. DiPippo, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Esha A. Gangolli, Valerie Gerlach, Loic Giot, Linda Gorman, Xiaojia (Sasha) Guo, Vladimir Y. Gusev, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, Martin D. Leach, Denise M. Lepley, Li Li, Xiaohong Liu, Uriel M. Malyankar, Charles E. Miller, Chean Eng Ooi, Tatiana Ort, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Richard A. Shimkets, Steven K. Spaderna, Kimberly A. Spytek, Raymond J. Taupier, Nancy Twomlow, Corine A.M. Vernet, Edward Z. Voss, Bryan D. Zerhusen, Mei Zhong
Publication number: 20040038877
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
October 1, 2002
Publication date:
February 26, 2004
Inventors:
John P. Alsobrook, David W. Anderson, Ferenc L. Boldog, Catherine E. Burgess, Elina Catterton, Shlomit R. Edinger, Karen Ellerman, Valerie Gerlach, Linda Gorman, Xiaojia (Sasha) Guo, Weizhen Ji, Ramesh Kekuda, Martin D. Leach, Li Li, Charles E. Miller, Meera Patturajan, Daniel K. Rieger, Mark E. Rothenberg, Richard A. Shimkets, Glennda Smithson, Kimberly A. Spytek, Raymond J. Taupier, Corine A.M. Vernet, Edward Z. Voss, Bryan D. Zerhusen, Mei Zhong
Publication number: 20040038223
Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
October 1, 2002
Publication date:
February 26, 2004
Inventors:
Glennda Smithson, Isabelle Millet, John A. Peyman, Ramesh Kekuda, Jingfang Ju, Li Li, Xiaojia (Sasha) Guo, Meera Patturajan, Kimberly A. Spytek, Shlomit R. Edinger, Karen Ellerman, Uriel M. Malyankar, Tatiana Ort, Linda Gorman, Bryan D. Zerhusen, David W. Anderson, Mei Zhong, Elina Catterton, Weizhen Ji, Charles E. Miller, Luca Rastelli, David J. Stone, Carol E. A. Pena, Suresh G. Shenoy, Richard A. Shimkets, Mark E. Rothenberg, Martin D. Leach, Michele L. Agee, Constance Berghs, Vincent A. DiPippo, Andrew Eisen, Esha A. Gangolli, Daniel K. Rieger, Steven K. Spaderna
