Patents by Inventor Martin D. Witte

Martin D. Witte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Using sortases to install click chemistry handles for protein ligation
    Patent number: 11028185
    Abstract: Methods and reagents for the installation of click chemistry handles on target proteins are provided, as well as modified proteins comprising click chemistry handles. Further, chimeric proteins, for example, bi-specific antibodies, that comprise two proteins conjugated via click chemistry, as well as methods for their generation and use are disclosed herein.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: June 8, 2021
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Hidde L. Ploegh, Martin D. Witte, Nicholas C. Yoder
  • Using sortases to install click chemistry handles for protein ligation
    Patent number: 10081684
    Abstract: Methods and reagents for the installation of click chemistry handles on target proteins are provided, as well as modified proteins comprising click chemistry handles. Further, chimeric proteins, for example, bi-specific antibodies, that comprise two proteins conjugated via click chemistry, as well as methods for their generation and use are disclosed herein.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: September 25, 2018
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Hidde L. Ploegh, Martin D. Witte, Nicholas C. Yoder
  • USING SORTASES TO INSTALL CLICK CHEMISTRY HANDLES FOR PROTEIN LIGATION
    Publication number: 20140249296
    Abstract: Methods and reagents for the installation of click chemistry handles on target proteins are provided, as well as modified proteins comprising click chemistry handles. Further, chimeric proteins, for example, bi-specific antibodies, that comprise two proteins conjugated via click chemistry, as well as methods for their generation and use are disclosed herein.
    Type: Application
    Filed: June 28, 2012
    Publication date: September 4, 2014
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Hidde L Ploegh, Martin D. Witte, Nicholas C. Yoder