Abstract: Methods of administering isolated anti-CD38 antibodies at low dosages subcutaneously are disclosed. The methods provide an effective treatment for autoimmune diseases and cancers, including hematologic diseases. Also disclosed are unit dosage forms for the anti-CD38 antibodies.

Abstract: A method of determining location of a vehicle includes: obtaining first map data including first identifiers of first objects and corresponding first locations and first uncertainties each of at least a first threshold distance; obtaining second map data including second identifiers of second objects and corresponding second locations and second uncertainties each of less than a second threshold distance, where the first threshold distance is at least twice the second threshold distance, and the first locations have a higher density than the second locations; and determining a location estimate, of the vehicle, based on at least a particular one of the second locations, corresponding to a particular one of the second objects, and at least one of an angle from the vehicle to the particular one of the second objects or a distance between the vehicle and the particular one of the second objects.

Abstract: The invention relates to a rolling bearing with two bearing rings and rolling elements running between same, and a sensor for detecting movements and/or positions of the bearing rings relative to one another, wherein the sensor is fastened to one of the bearing rings and is directed towards a measurement surface on the other bearing ring, wherein said measurement surface comprises a contour projection projecting towards the sensor and/or a contour recess open towards the sensor in the form of a groove or blind hole, which projection or groove influences the measurement signal of the sensor and the movement of which relative to the sensor transverse to the main signal direction of the sensor modifies the measurement signal of the sensor.

Abstract: Systems and methodologies for determining location of a vehicle is provided. The method includes obtaining a first location of the vehicle at a first time. A dead reckoning location of the vehicle is determined at a second time. Additionally, feature information is obtained at the second time. The feature information may be provided by a digital map or database, that includes records for at least some of the vehicle's surrounding objects. These records may include, for example, relative positional attributes in addition to the traditional absolute positions. Location measurements are obtained for one or more features that are identifiable based on the feature information. The dead reckoning location of the vehicle is corrected based on the location measurements.

Abstract: A wire activated rim brake system for a rollator partly positioned inside a rollator frame is disclosed. The system compromises a brake housing positioned close to a wheel of the rollator and inside the rollator frame, wherein the housing compromises an entry opening and sliding surfaces oriented at a right angle to the rotational axis of the wheel. The system further compromises a brake assembly to be positioned in the housing compromising a sliding section adapted to the slide along the sliding surfaces inside the housing and a brake section extending at a right angle from the sliding section and protruding through the entry opening. The system also comprises a brake path on the inner rim of the rollator wheel which is parallel with the rotational axis of the wheel.

Abstract: An adjusting drive for adjusting the rotational position of a large rolling bearing that comprises two bearing rings that can be rotated relative to each other, having an actuator for rotating the two bearing rings relative to each other. According to the invention, the actuating drive has a ring channel cylinder, which is formed in or on one of the bearing rings of the large rolling bearing, and at least one piston, which is received in the ring channel cylinder in a movable manner and is drivingly connected to the other bearing ring of the two bearing rings.

Abstract: A rope for reinforcing joints in fibre-reinforced composite structures is described. The rope comprises chopped reinforcement fibres and retaining means for retaining the chopped fibres in a rope-shape. Further, composite structures utilising such ropes as filler elements are described as well as an apparatus for manufacturing such ropes.

Abstract: The invention relates to a rolling bearing with two bearing rings and rolling elements running between same, and a sensor for detecting movements and/or positions of the bearing rings relative to one another, wherein the sensor is fastened to one of the bearing rings and is directed towards a measurement surface on the other bearing ring, wherein said measurement surface comprises a contour projection projecting towards the sensor and/or a contour recess open towards the sensor in the form of a groove or blind hole, which projection or groove influences the measurement signal of the sensor and the movement of which relative to the sensor transverse to the main signal direction of the sensor modifies the measurement signal of the sensor.

Abstract: In general, the invention relates to wind turbines, the rotor blades of which can be adjusted in terms of their pitch angle. The invention relates in particular to an actuating drive for adjusting the pitch angle of a rotor blade of a wind turbine, comprising a large rolling bearing which comprises two bearing rings that can be rotated relative to each other, and an actuator for rotating the two bearing rings relative to each other. According to the invention, the actuating drive comprises a ring channel cylinder, which is formed in one of the bearing rings, and at least one piston, which is received in the ring channel cylinder in a movable manner and is drivingly connected to the other bearing ring of the two bearing rings.

Abstract: The present invention relates to adjustment and/or drive units which can be used in wind power plants for adjusting the azimuth angle of the nacelle of the wind power plant or the pitch angle of the rotor blades, wherein such an adjustment and/or drive unit has at least two adjusting drives for rotating two assemblies which are mounted so as to be rotatable relative to each other, and has a control device for controlling the adjusting drives. The control device controls the adjusting drives in such a manner that the adjusting drives are braced relative to each other during the rotation of the two assemblies and/or when the assemblies are at standstill. The invention further relates to a wind power plant comprising such an adjustment and/or drive unit, and to a method for controlling such an adjustment and/or drive unit.

Abstract: Adjustment and/or drive units that can be used in wind turbines to set the azimuth angle of the wind turbine nacelle or the pitch angle of the rotor blades, wherein such an adjustment and/or drive unit has at least two actuating drives for rotating two assemblies, which are mounted for rotation relative to each other, and has a control device for controlling the actuating drives, which control device controls the actuating drives in such a way that the actuating drives are braced in relation to each other during the rotation of the two assemblies and/or at a standstill of the assemblies. The invention further relates to a wind turbine having such an adjustment and/or drive unit and to a method for controlling such an adjustment and/or drive unit.

Abstract: A wire activated rim brake system for a rollator partly positioned inside a rollator frame is disclosed. The system compromises a brake housing positioned close to a wheel of the rollator and inside the rollator frame, wherein the housing compromises an entry opening and sliding surfaces oriented at a right angle to the rotational axis of the wheel. The system further compromises a brake assembly to be positioned in the housing compromising a sliding section adapted to the slide along the sliding surfaces inside the housing and a brake section extending at a right angle from the sliding section and protruding through the entry opening. The system also comprises a brake path on the inner rim of the rollator wheel which is parallel with the rotational axis of the wheel.

Abstract: Methods of administering isolated anti-CD38 antibodies at low dosages subcutaneously are disclosed. The methods provide an effective treatment for autoimmune diseases and cancers, including hematologic diseases. Also disclosed are unit dosage forms for the anti-CD38 antibodies.

Abstract: The invention relates to a rolling bearing, in particular in the form of an open-center large rolling bearing, comprising a large number of rolling elements, which are held between at least two raceways, on which the rolling elements roll, wherein spacers are provided between the rolling elements, which spacers keep the rolling elements spaced apart from each other. According to the invention, at least one of the raceways has, in a center portion, an approximately groove-shaped longitudinal recess, in which support arms provided between the spacers run, which support arms reach around the rolling element between two adjacent spacers and support the adjacent spacers against each other in the running direction of the rolling elements.

Abstract: The present invention relates to an adjusting drive for adjusting the rotational position of a large rolling bearing that comprises two bearing rings that can be rotated relative to each other, having an actuator for rotating the two bearing rings relative to each other. According to the invention, the actuating drive has a ring channel cylinder, which is formed in or on one of the bearing rings of the large rolling bearing, and at least one piston, which is received in the ring channel cylinder in a movable manner and is drivingly connected to the other bearing ring of the two bearing rings.

Abstract: In general, the invention relates to wind turbines, the rotor blades of which can be adjusted in terms of their pitch angle. The invention relates in particular to an actuating drive for adjusting the pitch angle of a rotor blade of a wind turbine, comprising a large rolling bearing which comprises two bearing rings that can be rotated relative to each other, and an actuator for rotating the two bearing rings relative to each other. According to the invention, the actuating drive comprises a ring channel cylinder, which is formed in one of the bearing rings, and at least one piston, which is received in the ring channel cylinder in a movable manner and is drivingly connected to the other bearing ring of the two bearing rings.

Abstract: The invention relates to a rolling bearing, in particular in the form of an open-center large rolling bearing, comprising a large number of rolling elements, which are held between at least two raceways, on which the rolling elements roll, wherein spacers are provided between the rolling elements, which spacers keep the rolling elements spaced apart from each other. According to the invention, at least one of the raceways has, in a center portion, an approximately groove-shaped longitudinal recess, in which support arms provided between the spacers run, which support arms reach around the rolling element between two adjacent spacers and support the adjacent spacers against each other in the running direction of the rolling elements.

Abstract: A wind turbine blade is described, as well as a trailing edge plate for a wind turbine blade. A flexible flow modulation device, e.g. an acoustic flap or a plurality of serrations, is arranged at the trailing edge of a wind turbine blade, wherein the flexible device is coupled to at least one aerodynamic device, preferably vortex generators. As the flexible device is bent by action of flow over the wind turbine blade, the at least one aerodynamic device is deployed to provide for attached flow over the bent flexible device.

Abstract: Adjustment and/or drive units that can be used in wind turbines to set the azimuth angle of the wind turbine nacelle or the pitch angle of the rotor blades, wherein such an adjustment and/or drive unit has at least two actuating drives for rotating two assemblies, which are mounted for rotation relative to each other, and has a control device for controlling the actuating drives, which control device controls the actuating drives in such a way that the actuating drives are braced in relation to each other during the rotation of the two assemblies and/or at a standstill of the assemblies. The invention further relates to a wind turbine having such an adjustment and/or drive unit and to a method for controlling such an adjustment and/or drive unit.

Abstract: A wind turbine blade 2 for a rotor has a longitudinal direction extending from a root region 26 to a blade region. The wind turbine blade 2 is formed of a fibre-reinforced polymer material comprising a polymer matrix and a first and a second reinforcement fibre material being embedded in the polymer matrix. The wind turbine blade further comprises a first region being reinforced predominantly with the first reinforcement fibre material, a second region being reinforced predominantly with the second reinforcement fibre material, and a transition region between the first and the second region. The first region extends in the root region 26 and the first reinforcement fibre material is a metal.