Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: A method is provided for the multi-axis shaping of a hollow workpiece, such as a polygonal hollow workpiece. The hollow space of the workpiece has introduced into it a supporting core, which has a central body with at least two differently oriented, inter-communicating cylinder bores and also has pistons, which are accommodated in the cylinder bores and can be subjected to the action of pressure fluid through a fluid connection of the central body. Prior to the radial shaping of the workpiece in a radial press, in a process in which at least two radial dimensions are to be decreased, the supporting core is expanded radially, with the pistons being extended out of the cylinder bores by the pistons being subjected to the action of pressure fluid.

Abstract: In general, techniques are described by which to enable dedicated recovery modules for resolving issues with faulty applications. A server computing device comprising a memory and a. processor may perform various aspects of the techniques. The memory may store a faulty application indication identifying a faulty application of a plurality of applications hosted for distribution by the server computing device, where the faulty application has an issue occurring during execution of the faulty application by a user computing device. The processor may generate, based on the faulty application indication, a dedicated recovery module dial extends the faulty application, and output, to the user computing device, the dedicated recovery' module to resolve the issue occurring during execution of the faulty application.

Abstract: Methods and systems for providing a learning path for an electronic learning system.

Abstract: Embodiments herein describe using compressed source material to perform an atomic experiment or an atomic application within a vacuum chamber (e.g., an atom cooling and trapping apparatus). Source material is often refined and sold with dendritic or crystalline surfaces that result in a very large surface area. This surface area increases the likelihood that a large amount contaminants will form on the surface, which is especially true for reactive source materials. To mitigate the risk of contamination, in the embodiments herein the source material is compressed onto a substrate. This changes the material from having a dendritic or crystalline surface to a flat surface, which has a much smaller surface area and thus is less susceptible to contaminants which can, for example, improve the lifetime usage of the source material.

Abstract: There is provided a seal assembly comprising: a first component and a second component spaced apart from the first component so as to define a passage for the transfer of fluid from an inlet of the seal assembly to an outlet of the seal assembly, wherein the first component comprises a concavity at least partially defining the passage, and wherein no part of the second component extends into the portion of the passage bounded by the concavity.

Abstract: A radial press has at least six main jaws arranged concentrically and uniformly about a press axis to be moved radially in the direction of and away from the press axis by a drive unit. Each main jaw has a contact surface radially inwards and mechanical holding means for press jaws that can be attached in an exchangeable manner. A cutting tool is received in a tool installation area delimited outwardly by the main jaws. The cutting tool has multiple cutting attachments, each of which is attached to a main jaw and has a base structure. At least one of the cutting attachments has a cutting structure. Each base structure has a support surface which rests against the contact surface of the paired main jaw and at least one engagement element. The cutting structure protrudes from the paired base structure in the direction of the press axis.

Abstract: The disclosure provides a plurality of particles. Each particle may include a material comprising 0.95 to 1.30 mole fraction Li, at least 0.60 and less than 1.00 mole fraction Co, up to 10,000 ppm Al, 1.90 to 2.10 mole fraction O, and up to 0.30 mole fraction M, where M is at least one element selected from B, Na, Mg, P, Ti, Ca, V, Cr, Fe, Mn, Ni, Cu, Zn, Al, Sc, Y, Ga, Zr, Ru, Mo, La, Si, Nb, Ge, In, Sn, Sb, Te, and Ce. Each particle may also include a surface composition comprising a mixture of LiF and a metal fluoride. An amount of fluorine (F) is greater than 0 and less than or equal to 5000 ppm. The metal fluoride comprises a material selected from the group consisting of AlF3, CaF2, MgF2, and LaF2. The surface composition may also include a metal oxide comprising a material selected from the group consisting of TiO2, MgO, La2O3, CaO, and Al2O3. An amount of the metal oxide is greater than 0 and less than or equal to 20000 ppm.

Abstract: A computing device is described that includes one or more processors configured to receive a software development kit (SDK) bundle, wherein the SDK bundle comprises one or more SDK builds, package the SDK bundle into an SDK package configured to be installed on a device for access by one or more applications installed on the device, wherein each application is dependent upon an SDK build of the one or more SDK builds during runtime, and the software development kit package including the one or more software development kit builds, wherein each software development kit build from the one or more software development kit builds is configured to tun in a process on the device distinct from one or more processes in which the one or more applications run on the device.

Abstract: A novel projection system includes a base signal source, a highlight signal source, a base/highlight destination, and a shared optical element. A base signal provided by the base source and a highlight signal provided by the highlight source are combined by the shared optical element. In a particular embodiment, the base signal source and the highlight signal source each include a light source, a spatial light modulator, and optics, and the base/highlight destination includes optics and a spatial light modulator. In a more particular embodiment, the base signal source and the highlight source provide spatially modulated lightfields to the shared optical element. In another particular embodiment, the base signal and the highlight signal are modulated by the spatial light modulator of the base/highlight destination after being combined.

Abstract: Embodiments herein describe an ASIC design where certain portions of the laser driver are controllable by the user. In one embodiment, the ASIC may include one or more pins which provide a connection interface where the user can electrically connect a sense resistor that corresponds to the particular laser being used. The remaining portions of the laser driver are implemented in the ASIC, thereby giving the user the flexibility to adapt the laser driver to her selected laser while having the advantages that come from using an ASIC.

Abstract: A scaffold for regenerating a pulp of a root canal includes a body that has a pre-formed contour that closely matches a contour of the root canal. A method of making a customized regenerative scaffold includes generating a three-dimensional image of a root canal. The method also includes manufacturing the customized regenerative scaffold based on the three-dimensional image of the root canal.

Abstract: In general, techniques are described by which to perform memory efficient patching for computing devices. A server computing device comprising a memory and a processor may be configured to perform the techniques. The memory may store first assets that form an unpatched application and second assets that form a patched application. The processor may virtualize the first assets to obtain a single first virtual asset and obtain a single second virtual asset that represents the second assets. The processor may obtain, based on differences between the single first virtual asset and the single second virtual asset, a patch identifying how to update the single first virtual asset to obtain the single second virtual asset. The processor may next segment the patch into a plurality of segments and output to a user computing device a single segment from the plurality of segments for individual application by the user computing device.

Abstract: A scaffold for regenerating a pulp of a root canal includes a body that has a pre-formed contour that closely matches a contour of the root canal. A method of making a customized regenerative scaffold includes generating a three-dimensional image of a root canal. The method also includes manufacturing the customized regenerative scaffold based on the three-dimensional image of the root canal.

Abstract: Methods and systems for improving resource content mapping for an electronic learning system. The methods can include: receiving, by the electronic learning system, a resource for satisfying at least one learning objective of the one or more learning objectives, the resource comprising a content having a content data convertible into a text data and one or more resource property fields defining at least one characteristic of the resource; sectioning the content data into one or more content portions based on an analysis of at least one of the content data and the one or more resource property fields; and assigning at least one content portion of the one or more content portions to at least one learning objective.

Abstract: Methods and systems for providing a learning path for an electronic learning system.

Abstract: In general, techniques are described by which to perform memory efficient patching for computing devices. A server computing device comprising a memory and a processor may be configured to perform the techniques. The memory may store first assets that form an unpatched application and second assets that form a patched application. The processor may virtualize the first assets to obtain a single first virtual asset and obtain a single second virtual asset that represents the second assets. The processor may obtain, based on differences between the single first virtual asset and the single second virtual asset, a patch identifying how to update the single first virtual asset to obtain the single second virtual asset. The processor may next segment the patch into a plurality of segments and output to a user computing device a single segment from the plurality of segments for individual application by the user computing device.

Abstract: The present application relates to aqueous compositions for controlling a plant disease caused by a phytopathogenic organism, to methods of preparing such compositions and to uses of such compositions, for example for controlling a plant disease caused by a phytopathogenic organism. The aqueous compositions comprise copper ions, phosphorous acid and/or a salt thereof and an effective amount of an amine selected from an alkylamine, an alkanolamine and mixtures thereof. The pH of the compositions is from about 6 to about 10.

Abstract: Methods and systems for improving resource content mapping for an electronic learning system. The methods can include: receiving, by the electronic learning system, a resource for satisfying at least one learning objective of the one or more learning objectives, the resource comprising a content having a content data convertible into a text data and one or more resource property fields defining at least one characteristic of the resource; sectioning the content data into one or more content portions based on an analysis of at least one of the content data and the one or more resource property fields; and assigning at least one content portion of the one or more content portions to at least one learning objective.

Abstract: The present application relates to aqueous compositions for controlling a plant disease caused by a phytopathogenic organism, to methods of preparing such compositions and to uses of such compositions, for example for controlling a plant disease caused by a phytopathogenic organism. The aqueous compositions comprise copper ions, phosphorous acid and/or a salt thereof and an effective amount of an amine selected from an alkylamine, an alkanolamine and mixtures thereof. The pH of the compositions is from about 6 to about 10.