Patents by Inventor Martin De Borst

Martin De Borst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NEW BIOMARKERS TO ESTIMATE THE RISK OF ALLOGRAFT FAILURE AND PATIENT MORTALITY AFTER ORGAN TRANSPLANTATION
    Publication number: 20150153352
    Abstract: Circulating uncarboxylated Gla-proteins, in particular desphospho-uncarboxylated MGP(dp-ucMGP) and uncarboxylated osteocalcin (ucOC), are provided as prognostic biomarkers for allograft failure and mortality in patients who received organ transplantation and who are under immunosuppressive medication. A diagnostic tool is provided to monitor vitamin K status in such patients, i.e. the level of uncarboxylated species of extra-hepatic vitamin K-dependent proteins.
    Type: Application
    Filed: June 4, 2013
    Publication date: June 4, 2015
    Inventors: Cornelis Vermeer, Martin De Borst
  • USE OF VITAMIN K TO DECREASE ALLOGRAFT FAILURE AND PATIENT MORTALITY AFTER ORGAN TRANSPLANTATION
    Publication number: 20150141386
    Abstract: Poor vitamin K status is provided as an independent risk factor for allograft failure and mortality in patients who received organ transplantation and who are under immunosuppressive medication. Various forms and recommended dosages of vitamin K, optionally combined with vitamin D and/or other immunosuppressive medication, are provided to optimize the treatment of such patients resulting in decreased allograft failure and improved patient survival.
    Type: Application
    Filed: June 4, 2013
    Publication date: May 21, 2015
    Inventors: Cornelis Vermeer, Martin De Borst