Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: An HVAC component and method of forming the HVAC component, including a duct having a first surface and a second surface movable between an unassembled position and an assembled position is provided, wherein the method includes (a) applying a paint sealant to one of the first and the second surfaces; (b) one of drying or curing the applied paint sealant; and (c) moving the first and second surfaces from the unassembled to the assembled position, the paint sealant forming a sealed interface between the assembled first surface and second surface.

Abstract: An HVAC component and method of forming the HVAC component, including a duct having a first surface and a second surface movable between an unassembled position and an assembled position is provided, wherein the method includes (a) applying a paint sealant to one of the first and the second surfaces; (b) one of drying or curing the applied paint sealant; and (c) moving the first and second surfaces from the unassembled to the assembled position, the paint sealant forming a sealed interface between the assembled first surface and second surface.

Abstract: An HVAC component and method of forming the HVAC component, including a duct having a first surface and a second surface movable between an unassembled position and an assembled position is provided, wherein the method includes (a) applying a paint sealant to one of the first and the second surfaces; (b) one of drying or curing the applied paint sealant; and (c) moving the first and second surfaces from the unassembled to the assembled position, the paint sealant forming a sealed interface between the assembled first surface and second surface.

Abstract: An HVAC component and method of forming the HVAC component, including a duct having a first surface and a second surface movable between an unassembled position and an assembled position is provided, wherein the method includes (a) applying a paint sealant to one of the first and the second surfaces; (b) one of drying or curing the applied paint sealant; and (c) moving the first and second surfaces from the unassembled to the assembled position, the paint sealant forming a sealed interface between the assembled first surface and second surface.

Abstract: An HVAC component and method of forming the HVAC component, including a duct having a first surface and a second surface movable between an unassembled position and an assembled position is provided, wherein the method includes (a) applying a paint sealant to one of the first and the second surfaces; (b) one of drying or curing the applied paint sealant; and (c) moving the first and second surfaces from the unassembled to the assembled position, the paint sealant forming a sealed interface between the assembled first surface and second surface.

Abstract: A packing machine for wrapping compressed insulation products in heat sealable plastic film, including a forming tube having product feed means to move or hold the product within it, a former to reconfigure a web of heat sealable plastic film into a longitudinally open tube around the forming tube, a heat welder to close the longitudinal opening and provide a continuous plastic tube, take-off conveyors which receive the plastic tube containing the product at a point downstream of the forming tube and displace the product a preset distance from the forming tube to create a pocket, means to close the plastic tube behind the displaced product and ahead of the next product which is fed into the forming tube as the product is displaced, and means to cut the plastic tube between the two closures so formed, characterised in that air is removed from the pocket before closure by applying vacuum, thereby reducing the time for closing the plastic tube.

Abstract: For separating glass sheets, especially sheets of wired glass, into separate sheet portions and stacking the sheet portions in spaced stacks, the sheets are cut to define the sheet portions, which are gripped by respective relatively movable groups of suction gripping devices. The cutting may be effected by scoring the glass sheet before it is gripped by the suction devices, and then snapping it either before or after gripping it with the suction devices. The sheets may be lifted from a roller delivery conveyor into engagement with the suction gripping devices by a series of transverse lifting tines. The groups of suction gripping devices are then moved apart to separate the cut sheet portions, and in the case of wired glass this also severs the wires.