Abstract: The invention concerns a Proteolysis Targeting Chimera (PROTAC) or a pharmaceutically acceptable salt thereof for degradation of Aurora A-kinase in cells of a mammal which PROTAC has the chemical structure AAB-L-E3B, wherein AAB is a binding unit for Aurora A-kinase, L is a linker and E3B is a binding unit for E3-ubiquitin ligase Cereblon, wherein E3B comprises the structure of thalidomide or of one of its analogs lenalidomide, pomalidomide, and apremilast, wherein L comprises or consists of an alkyl ether residue or a polyalkyl ether residue or an alkyl ether residue or a polyalkyl ether residue in which at least one C—C bond is replaced by a C?C double bond, which polyalkyl ether residue has at least two ether groups or at least two ether groups in which one O-atom is replaced by an S-atom or a part of the O-atoms is replaced by S-atoms or wherein L comprises or consists of an alkyl thioether residue or a polyalkyl thioether residue or an alkyl thioether residue or a polyalkyl thioether residue in which at

Abstract: This pile installation system for an offshore foundation construction includes a main body, a movable part and a first means for attaching the main body to a frame of reference. This frame of reference is configured to act as a counterweight. It further includes a second means for attaching the movable part to a pile to be installed, and the movable part may be moved, with respect to the main body, in translation about the direction of an insertion axis.

Abstract: This pile installation system for an offshore foundation construction includes a main body, a movable part and a first means for attaching the main body to a frame of reference. This frame of reference is configured to act as a counterweight. It further includes a second means for attaching the movable part to a pile to be installed, and the movable part may be moved, with respect to the main body, in translation about the direction of an insertion axis.

Abstract: A vacuum pump includes a quick-rotatable component a bearing for supporting the quick-rotatable component and a lubricant pump for feeding lubricant to the bearing and having a rotor, with the bearing and the lubricant pump forming parts of a closed lubrication circuit having a hollow axle on which the rotor of the lubricant pump is rotatably supported.

Abstract: An arrangement for supporting a shaft of a vacuum pump includes a first bearing for supporting the shaft at one of its end, a second bearing for supporting the shaft at another of its ends and formed as a rolling bearing, a holder for receiving the second bearing and including an oscillating base, a fixation member secured in the vacuum pump housing, metallic connection members for connecting the oscillating base with the fixation member and axial springs arranged between the oscillating base and the fixation member and providing for the axial stiffness of the holder which is greater than its radial stiffness thereof and greater than the axial stiffness of the first bearing.

Abstract: A vacuum pump includes a quick-rotatable component a bearing for supporting the quick-rotatable component and a lubricant pump for feeding lubricant to the bearing and having a rotor, with the bearing and the lubricant pump forming parts of a closed lubrication circuit having a hollow axle on which the rotor of the lubricant pump is rotatably supported.

Abstract: A support device for rotatably supporting a rotor (1) and including a support rotor (2; 2?) connectable with the rotor (1); a support stator (3; 3?) and a connection element (5; 5?) displaceably supported in a housing portion (4a, 4b) of the support device and connected with the support stator (3; 3?), with the connection element (5; 5?) and the housing portion (4a, 4b) having each a flat surface (11; 10), and with the flat surfaces (11; 10) being located opposite each other and extending parallel to each other.

Abstract: An arrangement for supporting a shaft of a vacuum pump includes a first bearing for supporting the shaft at one of its end, a second bearing for supporting the shaft at another of its ends and formed as a rolling bearing, a holder for receiving the second bearing and including an oscillating base, a fixation member secured in the vacuum pump housing, metallic connection members for connecting the oscillating base with the fixation member and axial springs arranged between the oscillating base and the fixation member and providing for the axial stiffness of the holder which is greater than its radial stiffness thereof and greater than the axial stiffness of the first bearing.

Abstract: Method for identifying compounds useful for the therapy of cancers in which the activity of Myc is causally involved. The method is based on measuring the activity of the E3 ligase HectH9, which is required for ubiquitination and activation of Myc.

Abstract: The present invention describes the use of modulators of the signal transduction pathway via the protein kinase Fyn (e.g. Rho-kinase inhibitors or inhibitors of the protein kinase CSK) in the treatment of tumour diseases, especially in the therapy of neuroblastoma.

Abstract: The present invention provides assays for determining transcription-modulating substances. The transcription-modulating activity of test compounds is assessed on the basis of their ability to suppress or enhance complex formation between Myc and a novel zinc finger binding protein, Miz-1, or derivatives thereof.

Abstract: Method for identifying compounds useful for the therapy of cancers in which the activity of Myc is causally involved. The method is based on measuring the activity of the E3 ligase HectH9, which is required for ubiquitination and activation of Myc.

Abstract: The present application discloses nucleic acid constructs comprising nucleic acids which encode a protein which inhibits the cellular protein p27 and thereby relieves the inhibition of the proliferation of the cell which is brought about by p27, fragments and variants thereof, some of which possess a dominant interfering character.

Abstract: Novel Myc-binding zinc finger proteins, their preparation and their use are provided.