Abstract: There is provided a protein-RNA complex where here the protein is selected from one of Cpf1 and CAS13 and where the protein is Cpf1 and the RNA is an RNA guide strand which comprises a sequence that is one of SEQ ID NO 1 to 40 less the 5? TTTN motif of said SEQ ID NO 1-40, or the protein is CAS13 and the polynucleotide is an RNA guide strand that comprises a sequence that is complimentary to one of SEQ ID NO 41 to 80.

Abstract: A multicylinder internal combustion engine with an exhaust-driven turbocompressor and with a divided exhaust gas flow has at least two exhaust valves (2,3) and one intake valve per cylinder. A first exhaust valve (2) is connected to a first exhaust manifold which leads to the turbine of the compressor, while a second exhaust valve (3) is connected to a second exhaust manifold which opens downstream of the turbine. The charging pressure in the engine can be regulated by virtue of the opening periods of the exhaust valves (2,3) being varied in relation to one another in order to adapt the flow through the exhaust turbine to a value which provides the desired charging pressure in the engine. By opening the second exhaust valve (3) increasingly earlier, an increasingly lower charging pressure can be achieved.

Abstract: A multicylinder internal combustion engine with an exhaust-driven turbocompressor and with a divided exhaust gas flow has at least two exhaust valves (2,3) and one intake valve per cylinder. A first exhaust valve (2) is connected to a first exhaust manifold which leads to the turbine of the compressor, while a second exhaust valve (3) is connected to a second exhaust manifold which opens downstream of the turbine. The charging pressure in the engine can be regulated by virtue of the opening periods of the exhaust valves (2,3) being varied in relation to one another in order to adapt the flow through the exhaust turbine to a value which provides the desired charging pressure in the engine. By opening the second exhaust valve (3) increasingly earlier, an increasingly lower charging pressure can be achieved.