Patents by Inventor Martin F. Pera

Martin F. Pera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INDUCTION, PROPAGATION AND ISOLATION OF LIVER PROGENITOR CELLS
    Publication number: 20120329152
    Abstract: The present invention relates to methods of induction and isolation of progenitor cells from stem cell cultures, specifically liver progenitor cells from human embryonic stem cell cultures. In one embodiment, the present invention provides a method of inducing hepatocyte-like progenitor cells by placing a quantity of human embryonic stem cells in a medium supplemented with an inhibitor of the MAPK/MEK/ERK signaling pathway, FGFR, GSK3 and/or BMP.
    Type: Application
    Filed: August 31, 2012
    Publication date: December 27, 2012
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Martin F. Pera, Tracy Zinberg, Kouichi Hasegawa
  • Induction, propagation and isolation of liver progenitor cells
    Patent number: 8278105
    Abstract: The present invention relates to methods of induction and isolation of progenitor cells from stem cell cultures, specifically liver progenitor cells from human embryonic stem cell cultures. In one embodiment, the present invention provides a method of inducing hepatocyte-like progenitor cells by placing a quantity of human embryonic stem cells in a medium supplemented with an inhibitor of the MAPK/MEK/ERK signaling pathway, FGFR, GSK3 and/or BMP.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: October 2, 2012
    Assignee: University of Southern California
    Inventors: Martin F. Pera, Tracy L. Zinberg, Kouichi Hasegawa
  • INDUCTION, PROPAGATION AND ISOLATION OF LIVER PROGENITOR CELLS
    Publication number: 20100062527
    Abstract: The present invention relates to methods of induction and isolation of progenitor cells from stem cell cultures, specifically liver progenitor cells from human embryonic stem cell cultures. In one embodiment, the present invention provides a method of inducing hepatocyte-like progenitor cells by placing a quantity of human embryonic stem cells in a medium supplemented with an inhibitor of the MAPK/MEK/ERK signaling pathway, FGFR, GSK3 and/or BMP.
    Type: Application
    Filed: September 9, 2009
    Publication date: March 11, 2010
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Martin F. Pera, Tracy L. Zinberg, Kouichi Hasegawa
  • Compositions and Methods for Growth of Pluripotent Cells
    Publication number: 20090087907
    Abstract: A method of propagating embryonic stem (ES) cells in an undifferentiated state, while maintaining both the pluripotency and the cells normal genotype is disclosed. The method comprises using recombinantly produced protein domains to attach human embryonic stem cells to the surface of a bioreactor. The ES cells are supplied with nutrients while they held in place by the recombinantly produced protein domains which may be chosen from Laminin G domain, Fibronectin domain 2, Fibronectin domain 3, Nidogen G2 domain, Nidogen G3 domain, Vitronectin somatomedin B domain, and Vitronectin somatomedin C terminal domain. Useful molecules are characterized by a high binding affinity for hES cells and a molecular weight of about 50 kDa±20%.
    Type: Application
    Filed: July 31, 2006
    Publication date: April 2, 2009
    Inventors: Alice Pebay, Anna E. Michalska, Martin F. Pera