Patents by Inventor Martin F. Semmelhack
Martin F. Semmelhack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230303493Abstract: In one aspect, compounds and methods are described herein for treating gram negative bacteria having resistance to cationic antimicrobial peptides. In some embodiments, for example, compounds of formula I are provided. In another aspect, a treatment for a gram negative bacterial infection comprises a cationic antimicrobial protein (CAP) in conjunction with a compound of formula I.Type: ApplicationFiled: August 13, 2021Publication date: September 28, 2023Inventors: Laura Miller Conrad, Martin F. Semmelhack, Zinan Zhang, Minh Tran, Lauren Blankenship
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Patent number: 10285978Abstract: A structurally distinct and potent series of synthetic small molecule activators of Vibrio cholerae quorum sensing have been chemically synthesized. The small molecule activators reduce virulence in V. cholerae. Acyl pyrrole molecules displayed strong potency and stability, particularly 1-(1H-pyrrol-3-yl)decan-1-one.Type: GrantFiled: November 29, 2017Date of Patent: May 14, 2019Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Bonnie L. Bassler, Lark J. Perez, Martin F. Semmelhack
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Patent number: 9968587Abstract: A structurally distinct and potent series of synthetic small molecule activators of Vibrio cholerae quorum sensing have been chemically synthesized. The small molecule activators reduce virulence in V. cholerae. Acyl pyrrole molecules displayed strong potency and stability, particularly 1-(1H-pyrrol-3-yl)decan-1-one.Type: GrantFiled: August 19, 2014Date of Patent: May 15, 2018Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Bonnie L. Bassler, Lark J. Perez, Martin F. Semmelhack
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Publication number: 20180078526Abstract: A structurally distinct and potent series of synthetic small molecule activators of Vibrio cholerae quorum sensing have been chemically synthesized. The small molecule activators reduce virulence in V. cholerae. Acyl pyrrole molecules displayed strong potency and stability, particularly 1-(1H-pyrrol-3-yl)decan-1-one.Type: ApplicationFiled: November 29, 2017Publication date: March 22, 2018Applicant: The Trustees of Princeton UniversityInventors: Bonnie L. Bassler, Lark J. Perez, Martin F. Semmelhack
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Patent number: 9751851Abstract: Antivirulence strategies to combat Pseudomonas aeruginosa, are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the two P. aeruginosa quorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.Type: GrantFiled: September 19, 2014Date of Patent: September 5, 2017Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Bonnie L. Bassler, Martin F. Semmelhack, Knut Drescher, Albert Siryaporn, Laura C. Conrad-Miller, Colleen T. O'Loughlin
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Patent number: 9573908Abstract: Using a whole-cell high-throughput screen, eleven molecules were identified that activate V. cholerae quorum sensing (QS). Eight molecules are receptor agonists and three molecules are antagonists of LuxO, the central NtrC-type response regulator that controls the global V. cholerae QS cascade. Pro-QS molecules are used for the development of novel anti-infectives.Type: GrantFiled: February 20, 2013Date of Patent: February 21, 2017Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Bonnie L. Bassler, Wai-Leung Ng, Lark J. Perez, Jianping Cong, Martin F. Semmelhack
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Publication number: 20160368892Abstract: Antivirulence strategies to combat Pseudomonas aeruginosa, are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the two P. aeruginosa quorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.Type: ApplicationFiled: September 19, 2014Publication date: December 22, 2016Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Bonnie L. Bassler, Martin F. Semmelhack, Knut Drescher, Albert Siryaporn, Laura C. Conrad-Miller, Colleen T. O'Loughlin
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Publication number: 20150191765Abstract: The present invention relates to a method of measuring biofilms and/or biofilm streamers, wherein the method comprises a system that has at least one channel and a biofilm streamer promotion element, a fluid capable of moving along the channel, wherein the fluid has a flow driven by a controlled pressure; and a measuring element capable of measuring a flow rate of the fluid through the channel. Additionally, method of screening for compound(s) that promote and/or inhibit biofilm and/or biofilm streamers using this system are also contemplated. Uses of the system, methods and identified compounds are contemplated for medical and/or industrial environments.Type: ApplicationFiled: January 5, 2015Publication date: July 9, 2015Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Bonnie L. Bassler, Howard A. Stone, Martin F. Semmelhack, Knut Drescher, Yi Shen, Colleen T. O'Loughlin, Laura C. Miller
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Publication number: 20150126474Abstract: Using a whole-cell high-throughput screen, eleven molecules were identified that activate V. cholerae quorum sensing (QS). Eight molecules are receptor agonists and three molecules are antagonists of LuxO, the central NtrC-type response regulator that controls the global V. cholerae QS cascade. Pro-QS molecules are used for the development of novel anti-infectives.Type: ApplicationFiled: February 20, 2013Publication date: May 7, 2015Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Bonnie L. Bassler, Wai-Leung Ng, Lark J. Perez, Jianping Cong, Martin F. Semmelhack
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Publication number: 20100261914Abstract: Compounds that bind cellular IAPs (inhibitor of apoptosis proteins) are disclosed. The compounds are mimetics of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABOLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these compounds for therapeutic, diagnostic and assay purposes.Type: ApplicationFiled: April 16, 2010Publication date: October 14, 2010Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Yigong Shi, Martin F. Semmelhack, Martin Case, Philip A. Albiniak, George McLendon, Rachael A. Kipp, Aislyn D. Wist
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Patent number: 7718600Abstract: Compounds that bind cellular IAPs (inhibitor of apoptosis proteins) are disclosed. The compounds are mimetics of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABOLO, IIid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these compounds for therapeutic, diagnostic and assay purposes.Type: GrantFiled: July 15, 2003Date of Patent: May 18, 2010Assignee: The Trustees of Princeton UniversityInventors: George McLendon, Rachael A. Kipp, Martin Case, Yigong Shi, Martin F. Semmelhack, Philip A. Albiniak, Aislyn D. Wist
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Patent number: 7652172Abstract: This invention provides a practical synthesis route for 4,5-dihydroxypentane-2,3-dione (DPD), an unstable small molecule which is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis route includes new intermediates and allows preparation of isotopically-labeled DPD and ent-DPD. The method provides sufficient quantities of DPD for study of spontaneous binding of borate to DPD, the signal for the marine bacteria V. harveyi.Type: GrantFiled: September 20, 2005Date of Patent: January 26, 2010Assignee: The Trustees of Princeton UniversityInventors: Martin F. Semmelhack, Shawn R. Campagna, Bonnie L. Bassler, Michael J. Federle
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Publication number: 20090286873Abstract: This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.Type: ApplicationFiled: March 13, 2009Publication date: November 19, 2009Inventors: Stephen T. Miller, Karina B. Xavier, Michiko E. Taga, Shawn R. Campagna, Martin F. Semmelhack, Bonnie L. Bassler, Frederick M. Hughson
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Patent number: 7547726Abstract: This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.Type: GrantFiled: September 16, 2005Date of Patent: June 16, 2009Assignee: The Trustees of Princeton UniversityInventors: Stephen T. Miller, Karina B. Xavier, Michiko E. Taga, Shawn R. Campagna, Martin F. Semmelhack, Bonnie L. Bassler, Frederick M. Hughson
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Publication number: 20090018368Abstract: This invention provides a practical synthesis route for 4,5-dihydroxypentane-2,3-dione (DPD), an unstable small molecule which is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis route includes new intermediates and allows preparation of isotopically-labeled DPD and ent-DPD. The method provides sufficient quantities of DPD for study of spontaneous binding of borate to DPD, the signal for the marine bacteria V.Type: ApplicationFiled: September 20, 2005Publication date: January 15, 2009Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Martin F. Semmelhack, Shawn R. Campagna, Bonnie L. Bassler, Michael J. Federle