Abstract: The present invention relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to a therapeutic combination which comprises a PD-1 antagonist, an ATR inhibitor and a platinating agent.

Abstract: The present invention relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to a therapeutic combination which comprises a PD-1 antagonist, an ATR inhibitor and a platinating agent.

Abstract: The present invention comprises apparatus and methods for testing a tire on a wheel. Particular embodiments of such methods include providing a tire testing surface upon which the tire is to operate and a tire having a radially outer annular side including a road-engaging surface. The methods further include engaging forcefully a radially outer annular side of the tire with the tire testing surface to create a footprint constituting an area of contact between the tire and the tire testing surface, the footprint having a width extending in an axial direction of the tire. The tire is then rotated while engaged with the tire testing surface according to the prior step and a particulate is discharged from a particulate discharge outlet of a particular discharging device, the outlet having a length extending at least substantially across the width of the footprint.

Abstract: The invention is directed to the treatment of lung cancer, preferably non-small cell lung cancer (NSCLC) by means of a combination therapy comprising concurrent chemo-radiotherapy followed by vaccination with a muc-1 lipopetide. The therapy elicits prolonged survival rates compared to a respective therapy including sequential chemo-radiotherapy.

Abstract: The present invention comprises apparatus and methods for testing a tire on a wheel. Particular embodiments of such methods include providing a tire testing surface upon which the tire is to operate and a tire having a radially outer annular side including a road-engaging surface. The methods further include engaging forcefully a radially outer annular side of the tire with the tire testing surface to create a footprint constituting an area of contact between the tire and the tire testing surface, the footprint having a width extending in an axial direction of the tire. The tire is then rotated while engaged with the tire testing surface according to the prior step and a particulate is discharged from a particulate discharge outlet of a particular discharging device, the outlet having a length extending at least substantially across the width of the footprint.

Abstract: A cooling and lubricating device for rollers of a cold rolling mill with one or more roll stands for controlling strip tensile stress of the strip across the width by changing the effective roll barrel diameter and/or the roller lubrication with a controlled supply of rolling oil or emulsions. The supply is pressure-, quantity-, and/or temperature-controlled. Several nozzle beams are provided and assigned to individual rollers, respectively. The nozzle beams are connected to side shields of the roll housing. Spray nozzles are mounted in the nozzle beams and distributed across the entire roller width. The nozzle beams are moveable independently relative to the rollers transverse to the strip running direction and in planes parallel to the strip plane. Rotary and linear drives are connected to the nozzle beams for rotating the nozzle beams about the longitudinal axis and for moving them in the longitudinal direction.