Abstract: The invention is directed to a multi-arm tissue-adhesive polymer wherein at least six or more arms each comprise a reactive functional group that can form a urethane or a urea bond with an amine group present in tissue, as well as to the use thereof for sealing or closing of tissue and use in a medical treatment of a human or animal body. In a further aspect, the invention is directed to a method for the preparation of said multi-arm tissue-adhesive polymer.

Abstract: The invention is directed to a tissue-adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue-reactive polymer as well as to a tissue-adhesive device for sealing dura mater comprising said tissue-adhesive polymer blend.

Abstract: The invention is directed to biomedical polyurethanes. The invention is particularly directed to biomedical polyurethanes with improved biodegradability and to an improved preparation of the biomedical polyurethanes. In particular the present invention provides a biomedical polyurethane having the formula (A-B-C-B)n, wherein A denotes a polyol, B denotes a diisocyanate moiety, C denotes a diol component and n denotes the number of recurring units, and wherein the B-C-B segment is bioresorbable.

Abstract: The invention is directed to biomedical polyurethanes. The invention is particularly directed to biomedical polyurethanes with improved biodegradability and to an improved preparation of the biomedical polyurethanes. In particular the present invention provides a biomedical polyurethane having the formula (A-B-C-B)n, wherein A denotes a polyol, B denotes a diisocyanate moiety, C denotes a diol component and n denotes the number of recurring units, and wherein the B-C-B segment is bioresorbable.

Abstract: The invention is directed to a multilayered drug eluting biodegradable foam comprising at least two layers, wherein each layer independently comprises a polymer and wherein at least one of said layers is a drug-comprising layer, which comprises at least one drug that is mixed with the polymer in said drug-comprising layer.

Abstract: The invention is directed to a tissue-adhesive multi-arm polymer comprising a core from which polymeric arms extent, which polymeric arms are substituted with a hydroxyl-substituted aromatic group based on compounds such as dopamine, L-DOPA, D-DOPA, tyramine, noradrenaline and/or serotonin. In addition, the invention is directed to a caprolactam blocked hydroxyl-substituted aromatic compound, suitable for the preparation of the tissue-adhesive multi-arm polymer and to the method for the preparation of the tissue-adhesive multi-arm polymer.

Abstract: The invention is directed to a multilayered drug eluting biodegradable foam comprising at least two layers, wherein each layer independently comprises a polymer and wherein at least one of said layers is a drug-comprising layer, which comprises at least one drug that is mixed with the polymer in said drug-comprising layer.

Abstract: The invention is directed to a biodegradable tissue-adhesive device for sealing tissue, said device comprising a tissue-adhesive layer which comprises a blend of a tissue-reactive polymer and a biodegradable carrier polyurethane according to the formula of A-B-C-Bn, wherein A denotes a polyol, B denotes a diisocyanate moiety, C denotes a diol component and n denotes the number of recurring units, and wherein the B-C-B segment is bioresorbable.

Abstract: The invention is directed to a biodegradable tissue-adhesive polyurethane polymer comprising at least one amorphous segment and at least one polyurethane segment, wherein at least one of said polyurethane segment comprises a tissue-reactive functional group. A further aspect of the invention is directed to biodegradable tissue-adhesive medical devices, based on the polyurethane polymer, having the structure of a sheet, foam, stent, tube or gel. The polyurethane polymer and the device can be used in medical application.

Abstract: The invention is directed to a tissue-adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue-reactive polymer as well as to a tissue-adhesive device for sealing dura mater comprising said tissue-adhesive polymer blend.

Abstract: The invention is directed to a multi-arm tissue-adhesive polymer wherein at least six or more arms each comprise a reactive functional group that can form a urethane or a urea bond with an amine group present in tissue, as well as to the use thereof for sealing or closing of tissue and use in a medical treatment of a human or animal body. In a further aspect, the invention is directed to a method for the preparation of said multi-arm tissue-adhesive polymer.

Abstract: The invention is directed to a biodegradable tissue-adhesive device for sealing tissue, said device comprising a tissue-adhesive layer which comprises a blend of a tissue-reactive polymer and a biodegradable carrier polyurethane according to the formula of ?A-B-C-B?n, wherein A denotes a polyol, B denotes a diisocyanate moiety, C denotes a diol component and n denotes the number of recurring units, and wherein the B-C-B segment is bioresorbable.

Abstract: The invention is directed to a biodegradable tissue-adhesive polyurethane polymer comprising at least one amorphous segment and at least one polyurethane segment, wherein at least one of said polyurethane segment comprises a tissue-reactive functional group. A further aspect of the invention is directed to biodegradable tissue-adhesive medical devices, based on the polyurethane polymer, having the structure of a sheet, foam, stent, tube or gel. The polyurethane polymer and the device can be used in medical application.

Abstract: The invention is directed to a tissue-adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue-reactive polymer as well as to a tissue-adhesive device for sealing dura mater comprising said tissue-adhesive polymer blend.

Abstract: The invention is directed to a multilayered drug eluting biodegradable foam comprising at least two layers, wherein each layer independently comprises a polymer and wherein at least one of said layers is a drug-comprising layer, which comprises at least one drug that is mixed with the polymer in said drug-comprising layer.

Abstract: The invention is directed to biomedical polyurethanes. The invention is particularly directed to biomedical polyurethanes with improved biodegradability and to an improved preparation of the biomedical polyurethanes. In particular the present invention provides a biomedical polyurethane having the formula (A-B-C-B)n, wherein A denotes a polyol, B denotes a diisocyanate moiety, C denotes a diol component and n denotes the number of recurring units, and wherein the B-C-B segment is bioresorbable.

Abstract: The invention is directed to a multilayered drug eluting biodegradable foam comprising at least two layers, wherein each layer independently comprises a polymer and wherein at least one of said layers is a drug-comprising layer, which comprises at least one drug that is mixed with the polymer in said drug-comprising layer.

Abstract: The invention relates to processes for preparing a synthetic foam having present therein particles with a controlled particle distribution and the use of said foam, as well as to foams as such. Accordingly the invention is directed to a process for preparing a synthetic foam having present therein particles, wherein the distribution of said particles is controlled by the following steps of dissolving at least one synthetic polymer in one or more solvents to form a solution; contacting particles with said solution to form a polymer/particles mixture; and freeze-drying the polymer/particles mixture by: freezing the polymer/particles mixture; and subsequently subliming the one or more solvents to form a synthetic foam comprising said particles.

Abstract: The invention relates to processes for preparing a synthetic foam having present therein particles with a controlled particle distribution and the use of said foam, as well as to foams as such. Accordingly the invention is directed to a process for preparing a synthetic foam having present therein particles, wherein the distribution of said particles is controlled by the following steps of dissolving at least one synthetic polymer in one or more solvents to form a solution; contacting particles with said solution to form a polymer/particles mixture; and freeze-drying the polymer/particles mixture by: freezing the polymer/particles mixture; and subsequently subliming the one or more solvents to form a synthetic foam comprising said particles.