Abstract: The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.

Abstract: A method for additive manufacturing of an item includes a first solidification step and a second solidification step. In the first solidification step, at least one structure section having a first degree of solidification is formed. The at least one structure section delimits at least one interior accommodating a liquid construction material. The item is a three-dimensional object having a resin-based construction material which is liquid in a base state and is solidifiable. In the second solidification step a deformation section is formed. The deformation section has a second degree of solidification that is different from the first degree of solidification. The deformation section is formed from the liquid construction material accommodated in the interior.

Abstract: A method for manufacturing a decorative component includes providing an embossing device which has female embossing mold and male embossing mold, and providing at least one decorative material layer. The method also includes disposing the decorative material layer between the female embossing mold and the male embossing mold in such a manner that a visible surface of the decorative material layer faces the female embossing mold, and a reverse face of the decorative material layer that is opposite the visible surface faces the male embossing mold. The method also includes carrying out an embossing procedure by means of the embossing device such that the decorative material layer after the embossing procedure has a raised region on the visible surface, and opposite thereto a depressed region on the reverse face. The method also includes disposing an insert element for stabilizing the raised region in the depressed region.

Abstract: A method for producing a structural component having a foam structure formed by foaming a foamable material, includes the following steps: additively building a receiving component that reproduces the outer geometry of the structural component to be produced at least in some sections, in particular completely, and having a receiving space for receiving foamable material; introducing at least one foamable material into the receiving space of the receiving component; and carrying out at least one measure for foaming the foamable material introduced into the receiving space of the receiving component so as to form the foam structure.

Abstract: A lighting device includes lens which delimits the inner region of the lighting device and is configured so that light exits outwards from the inner region. The lighting device includes one or more light sources in the inner region to emit a first light radiation in a first wavelength range, the lens being non-transparent to the first light radiation. The inner region also includes one or more elements, each of which contains a photoluminescent phosphor, the element(s) being arranged to be illuminated by the first light radiation. The photoluminescent phosphor is configured to emit a second light radiation in a second wavelength range, based on the first light radiation illuminating the element(s), the second light radiation at least partly exiting through the lens which is transparent to at least a part of the second light radiation.

Abstract: For the purpose of simplified production of a motor vehicle seat which can be used in a versatile manner, with a seat part, a backrest and a headrest, the seat part and/or the backrest and/or the headrest have or has a number of chambers which are produced additively from an elastic material, particularly preferably silicone and/or a polyurethane, and which are in each case designed to be filled at least temporarily with a fluid.

Abstract: Methods and systems for designing a photonic computational architecture including a plurality of optical components. At least some of the methods include: defining a loss function within a simulation space composed of a plurality of voxels, the simulation space encompassing the plurality of optical components; defining an initial structure for the photonic computational architecture in the simulation space, at least some of the voxels corresponding to each of the plurality of optical components and having a dimension smaller than an operative wavelength of the computational architecture; determining values for at least one structural parameter and/or at least one functional parameter for each of the plurality of optical components using a numerical solver to solve Maxwell's equations; and defining a final structure of the photonic computational architecture based on the values for the one or more structural and/or functional parameters.

Abstract: A device for determining orientation of an object, including a measurement body, which reflects electromagnetic radiation and can be brought into physical contact with a surface of the object to determine the orientation. The device includes: a measurement carriage movable along the object during the determination of the orientation and which has a sliding surface that can be brought into physical contact with the object; a retaining unit which retains the measurement body and is connected to the measurement carriage so as to be pivotable between a maximal position, in which the measurement body protrudes beyond the sliding surface on the object side, and a minimal position, in which the measurement body does not protrude beyond the sliding surface on the object side; and a restoring device that applies a force to the retaining unit toward the maximal position.

Abstract: A securing element for a motor vehicle has a hermetic body made of plastic which encloses a cavity. The cavity is filled with a filling medium. The thermal expansion coefficient of the filling medium is, up to a softening temperature of the plastic, greater than the thermal expansion coefficient of the plastic. A cover for an interior mirror base of a motor vehicle includes such a securing element.

Abstract: A functional component for a vehicle is formed from at least one temperature-sensitive material and/or has at least one temperature-sensitive material, which is designed in such a way that, at at least a predefined limit temperature, an optically perceptible property for representing a temperature information, which describes the temperature of at least a part of the functional component, can be modified.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for correcting finite floating-point numerical simulation and optimization. Defining a loss function within a simulation space composed of a plurality of voxels each having an initial degree of freedom, the simulation space encompassing one or more interfaces of the component; defining an initial structure for the one or more interfaces in the simulation space; calculating, using a computer system with a finite floating-point precision, values for an electromagnetic field at each voxel using a finite-difference time domain solver to solve Maxwell's equations; and determining, for each voxel, whether to increase a respective numerical precision of respective values representing behavior of the electromagnetic field at the voxel above a threshold precision by the computer system and, in response, assigning one or more additional degrees of freedom to the voxel.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for designing a multimodal photonic component. In one aspect, a method includes defining a loss function within a simulation space including multiple voxels and encompassing features of the multimodal photonic component. The loss function corresponds to a target output mode profile for an input mode profile, where the target output mode profile includes a relationship between a set of operating conditions and one or more supported modes of the multimodal photonic component at a particular operative wavelength. The initial structure is defined for one or more features, where at least some of the voxels corresponding to features have a dimension smaller than a smallest operative wavelength of the multimodal photonic component, and values for structural parameters for the features are determined so that a loss according to the loss function is within a threshold loss.

Abstract: A computer-implemented method for designing a dispersive optical component includes: (i) defining a loss function within a simulation space composed of multiple voxels, the simulation space encompassing optical interfaces of the component, the loss function corresponding to a target dispersion profile for the component including a relationship between a scattering angle and a wavelength of an incident electromagnetic field for different operative wavelengths; (ii) defining an initial structure for the optical interfaces, at least some of the voxels corresponding to each optical interface having a dimension smaller than a smallest operative wavelength of the component; and (iii) determining, using a computer system, a structure for each optical interface using a finite-difference time domain solver to solve Maxwell's equations so that a loss determined according to the loss function is above a specified threshold.

Abstract: Methods for designing a mode-selective optical device including one or more optical interfaces defining an optical cavity include: defining a loss function within a simulation space encompassing the optical device, the loss function corresponding to an electromagnetic field having an operative wavelength within the optical device resulting from an interaction between an input electromagnetic field at the operative wavelength and the one or more optical interfaces of the optical device; defining an initial structure for each of the one or more optical interfaces, each initial structure being defined using a plurality of voxels; determining values for at least one structural parameter and/or at least one functional parameter of the one or more optical interfaces by solving Maxwell's equations; and defining a final structure of the one or more optical interfaces based on the values for the one or more structural and/or functional parameters.

Abstract: A lighting device includes lens which delimits the inner region of the lighting device and is configured so that light exits outwards from the inner region. The lighting device includes one or more light sources in the inner region to emit a first light radiation in a first wavelength range, the lens being non-transparent to the first light radiation. The inner region also includes one or more elements, each of which contains a photoluminescent phosphor, the element(s) being arranged to be illuminated by the first light radiation. The photoluminescent phosphor is configured to emit a second light radiation in a second wavelength range, based on the first light radiation illuminating the element(s), the second light radiation at least partly exiting through the lens which is transparent to at least a part of the second light radiation.

Abstract: Systems and methods for designing a hybrid neural network comprising at least one physical neural network component and at least one digital neural network component. A loss function is defined within a design space composed of a plurality of voxels, the design space encompassing one or more physical structures of the at least one physical neural network component and one or more architectural features of the digital neural network. Values are determined for at least one functional parameter for the one or more physical structures, and the at least one architectural parameter for the one or more architectural features, using a domain solver to solve Maxwell's equations so that a loss determined according to the loss function is within a threshold loss. Final structures are defined for the at least one physical neural network component and the digital neural network component based on the values.

Abstract: A method that includes: providing a substrate including a layer of a crystalline material having a first surface; and exposing the first surface to an environment under conditions sufficient to cause epitaxial growth of a layer of a deposition material on the first surface, wherein exposing the first surface to the environment includes illuminating the substrate with light at a first wavelength while causing the epitaxial growth of the layer of the deposition material. The first surface includes one or more discrete growth sites at which an epitaxial growth rate of the quantum confined nanostructure material is larger than areas of the first surface away from the growth sites by an amount sufficient so that the deposition material forms a quantum confined nanostructure at each of the one or more discrete growth sites.

Abstract: An example method may include receiving, from a client computing device, an indication of a target drop-off spot for an object within a first virtual model of a first region of a delivery destination. A second virtual model of a second region of the delivery destination may be determined based on sensor data received from one or more sensors on a delivery vehicle. A mapping may be determined between physical features represented in the first virtual model and physical features represented in the second virtual model to determine an overlapping region between the first and second virtual models. A position of the target drop-off spot within the second virtual model may be determined based on the overlapping region. Based on the position of the target drop-off spot within the second virtual model, the delivery vehicle may be navigated to the target drop-off spot to drop off the object.

Abstract: A method produces a vehicle replacement part for a first vehicle component of a connecting system, which is fixed to a second vehicle component via a detachable clip connection. The first vehicle component has a male fixing element, and the second vehicle component has a female fixing element. To connect the first vehicle component to the second vehicle component, the male fixing element is plugged into the female fixing element and is latched. The production method of the vehicle replacement part provides an unfinished part, which is dimensioned to produce the vehicle replacement part. Then, the unfinished part is reshaped in accordance with the geometry of the first vehicle component. Male fixing elements are then provided and, in the last step, the male fixing elements are joined to the reshaped unfinished part.

Abstract: An MMS includes a substrate, an element movable with respect to the substrate and a frame structure. A first pair of springs is arranged between the substrate and the frame structure along a first spring direction. A second pair of springs is arranged between the movable element and the frame structure along a second spring direction. The frame structure is configured to generate tensile stress in the second pair of springs at tensile stress acting in the first pair of springs.